猴痘多国疫情，外部形势报告第60号-2025年12月8日

Multi-countryexternalsituationreportno.60published8December2025 Highlights •All clades ofthemonkeypox virus (MPXV)continuetocirculate.Whenmpox outbreaks are notrapidlycontained and human-to-human transmission is notinterrupted,thereisa risk of sustained communitytransmission. •InOctober2025, 44countries, across all WHO regions, reporteda total of2501 newconfirmedmpoxcases, including 12 deaths (case fatality ratio [CFR] 0.5%).About75% of these cases werereportedinthe African Region.All regions, apart from theSouth-East AsiaRegionobservedadeclineinconfirmed •Twenty-onecountries in Africa havereportedactive transmission of mpox in the last six weeks(12October–23 November2025), with1734confirmed cases, including10deaths (CFR0.6%)reportedduring this period.Countries reporting the highest numberof casesin this period are the Democratic •One country, Mali,has reported mpox forthe first time. The case reporteda recent history of traveltoGuinea. Genomic sequencing analysis is ongoing to determine the MPXV clade. •New imported cases ofmpox due toclade IbMPXVdetected amongtravellershave been reported in •Outside Africa, local transmission of clade Ib MPXVhas beenoccurring in Italy,the Netherlands, Epidemiological update Thissituation report includesthe most relevantnewinformationonmpox outbreaks and response activities. Global monkeypox virus (MPXV) distribution Since thelast situation report,Malihas reported its first case of mpox, clade to be determined(detaileddescriptionbelow),andGreecehasreportedthe detection ofclade Ib MPXV for the first time (Figure 1).Detailed information Community transmission of clade Ib MPXV(Figure 2)continues to bereportedacross three other WHO regionsoutside Central and East Africa: the European Region(Italy, theNetherlands, Portugal and Spain), the Region ofthe Americas(the United States of America), and theWestern PacificRegion(Malaysia).Althoughnoadditional Global situation Global surveillancedataareupdatedmonthly;the latestdata availableareas of31 October2025.InOctober2025,44countriesgloballyreported a total of2501newconfirmed cases(Figure 3), including12deaths (casefatality ratio [CFR] 0.5%)2. The countries with the highest number of cases in the last month arein the African Region (Figure3)whichreported75% (1868of2501)of confirmed casesreported globallyinOctober2025.Theregionaltrendof Theonlyregion reportingan increase inconfirmedcasesinOctober2025compared toSeptember2025 TheRegion of the Americas,theEastern Mediterranean,African,European,andWestern Pacificregionsreportedamonthlydecrease in casesforOctober2025,comparedtoSeptember2025, of52%,50%,38%,25%,and19%respectively. Figure 4.Epidemic curve ofthenumber of confirmed mpox cases reported to WHO, bymonth and byWHO region, 1November2024–31 October2025 Situation in Africa This sectionreports on dataas of23November2025. From 1 January to23 November2025,28countries in Africa reported42 147confirmed mpox cases,including192deaths(CFR0.5%).Twenty-onecountrieson the continenthavereportedactive transmission of mpox inthe lastsixweeks(Figure5), with1734confirmed cases, including 10deaths (CFR 0.6%) reported during thisperiod.Maliis the latest countrytoreport mpox for the first time,inNovember2025.Countries reporting the Overall,weeklyconfirmed casesreportedcontinue to decline (Figure 6). However, data for the most recentweeks should be interpreted with caution, as reporting delays often lead to retrospective adjustments.Overall,fewer than500 new confirmed casesper weekhave been reported inthe lastfourweeks.Thiscontinentaltrendhasmostlybeeninfluenced bythe decrease incasecountsreported in the Democratic Republic of the Focus on selected countries Ghana In 2025, as of 23 November 2025, Ghana has reported atotal of891 confirmed mpox cases, including threedeaths (CFR 0.3%). Whilesporadicconfirmed cases were detected in late 2024 and early 2025, alargeoutbreakbegan in May 2025,withpersistent weekly case reporting throughout the subsequent months (Figure7). Although weekly incidence has fluctuated, Ghana continues to report several dozen confirmed cases per The most affected areas include Western, Greater Accra, Ashanti, Bono East, and Volta regions.Cases havebeen confirmed inall 16 regions, with at least 112 districts affected, reflecting widespread geographic Although detailed transmission-chain investigations remain limited, the overall epidemic pattern appearsconsistent with other clade IIb MPXV outbreaks reported in the West African region, where sexual contactlikelycontributes to the sustainedtransmissioncurrently observed.Vaccination activities are ongoing, withmore than Guinea In 2025, as of 23 November 2025,Guinea has reported1736confirmed mpox cases, includingsixdeaths(CFR0.3%). Whileonlysporadic confirmed cases were detected in late 2024, a marked increase and sustainedtransmissionbeganin June 2025, followed by a rapid acceleration in July. Weekly confirmed cases peaked atover 110 cases per week between Augu