External Situation Report n.32, published26November2025 Countries affected–32Since Jan.2025 Inthisedition: •Overview•Global epidemiological update•WHO regional overviews•Focuson selectedsubregions andcountries•Operational updates•Keychallenges Overview Dataasof26 October2025 •Thedata presented hereshould be interpretedwithcaution.Potential underreporting and reporting delaysmayaffect timeliness and accuracy, whilevariations in surveillance systems,standardcase definitions, and laboratorycapacitiescanlimit direct comparabilityamongcountries.These factors also influencethe global case fatality rate(CFR), requiring careful examination.Unless otherwisespecified, the term 'cholera cases'includesboth suspected •In October 2025(epidemiological weeks40to43) a total of35026new cholera and acute watery diarrhoea (AWD)cases were reported from 20countries, territoriesandareas (hereafter countries) acrossfourWHO regions,showing a34% decrease fromSeptember.In thisperiod335cholera-related deathswerereportedglobally, a •Cholera cases and deaths inOctober2025 wereboth44% lower than inOctober2024 (63 030cases and599 •From 1 January to26October2025, a cumulative total of 565404cholera cases and7074deaths were reportedfrom 32 countries across fiveWHO regions, with the Eastern Mediterranean Region recording the highestnumbers, followed by the African Region, the South-East Asia Region,the Region of the Americas, and the InOctober2025, the average stockpile of Oral Cholera Vaccine (OCV) was7.9milliondoses,exceedingthe •In recent years, conflict, mass displacement, disasters from natural hazards, and climate change have intensifiedoutbreaks, particularly in rural and flood-affected areas, where poor infrastructure and limited healthcare access Globalepidemiological update InOctober2025, (epidemiological weeks40to43), a total of35 026new cholera and AWD cases were reported from20countries across four WHO regions, showing a34% decrease from the previous month. The Eastern MediterraneanRegion (21 451cases; four countries) reported the highest number of cases, followed by the African Region (13 253cases, 13 countries), the South-East Asia Region (200cases,twocountries), the Region of the Americas (122cases,onecountry).Duringthe same period,335cholera-related deaths werereported, representing a55% decreaseas From 1 January to 26October2025, a cumulative total of 565404cholera and AWD cases and7074deaths werereported globally across five WHO regions. The Eastern Mediterranean Region reported the highest case count (329208cases; six countries), followed by the African Region (223 452cases, 21 countries), the South-East Asia Region(6077cases; five countries), the Region of the Americas (5353cases; one country),and the Western Pacific Region WHOregionaloverviews African Region In October 2025, the African Region reported 13 253 new cholera cases across 13 countries, marking a 19% decreasecompared withSeptember.The highest number ofcases were reported fromtheDemocratic Republic of the Congo(4633), Angola (3628),andSouth Sudan (1334).Additionally, there were 272 cholera-related deaths, a 24% decrease From 1 January 2025 to 26 October 2025, a total of 223 452 cholera cases were reported across 21 countries in theAfrican Region.The highest number of cases were reported from South Sudan (78772),theDemocratic Republic ofthe Congo (61089)andAngola (32975).Duringthe same period, a total of 4955 deaths were reported from 18 Eastern Mediterranean Region In October 2025, the Eastern Mediterranean Region reported 21 451 new cholera cases acrossfourcountries,marking a 39% decrease compared withSeptember.The highest numbers ofcases were reported from Afghanistan(12696), Yemen (6377)andSudan (1966).Additionally, there were 63 cholera-related deaths, a 84% decrease From 1 January 2025 to 26 October 2025, a total of 329 208 cholera cases were reported acrosssixcountries in theEastern Mediterranean Region.The highest numbersofcases were reported from Afghanistan (145907), Yemen (87 Region of the Americas In October 2025, the Region of the Americas reported 122 new cholera casesfrom Haiti,marking a 4% decrease From 1 January 2025 to 26 October 2025, a total of 5 353 cholera casesand 78 deathswere reportedfrom Haiti. South-East Asia Region In October 2025, the South-East Asia Region reported 200 new cholera cases acrosstwocountries, marking a 85%decrease compared withSeptember.Cases were reported from Nepal (143)andMyanmar (57).there were no From 1 January 2025 to 26 October 2025, a total of 6 077 cholera cases were reported acrossfivecountries in theSouth-East Asia Region.The highest number ofcases were reported from Myanmar (2280), India (1923)andNepal Western PacificRegion InOctober2025, no new casesordeaths were reported from the Western Pacific Region.From 1 January 2025 to26 October 2025, a total of 1 314 cholera casesand 14 deathswerereported from the Philippines. Focus on selectedsubregions andcountries Angola In Octob