永泰生物-B2023年度报告

目錄 公司資料2公司概況4業務及財務摘要5管理層討論及分析10董事及高級管理層25董事會報告32企業管治報告60財務概要74環境、社會及管治報告76獨立核數師報告126綜合損益及其他全面收益表131綜合財務狀況表132綜合權益變動表134綜合現金流量表135綜合財務報表附註137釋義208 20233 24 20238 2520233 2420233 2420233 2420238 25 •88135 183401 255 P.O. Box 309Ugland HouseGrand Cayman KY1-1104Cayman Islands 1816 Maples Fund Services (Cayman) LimitedP.O. Box 1093, Boundary HallCricket SquareGrand Cayman, KY1-1102Cayman Islands 17 183171712-1716 118 6978 131www.eaal.net 20207 10 18TEAL®2006EAL®EAL® EAL®EAL® EAL®6B11CAR-TTCR-T EAL® EAL®EAL®TCD8+TCD3 EAL®IIEAL®EAL®20239EAL®EAL®EAL®II4302024NDA2025 6B11-OCIK 6B11-OCIKT6B11COC166-9OC166-96B116B11-OCIK 6B11-OCIKI CAR-T CAR-T–19 CAR-TCAR-T-19CAR-T-19B(B-ALL)IND20198 INDCAR-T-19I20212 25I202310IIICAR-T-19II2026 RC19D2CAR-T-19-D2 CAR-T-19-DNRTGFBCAR-T I20242025 aT19 aT19CD19TCD19CAR-T-19aT19CAR-TCAR-TCD19CD19CAR-TCAR-TCD19aT19CAR-T-19T aT19IINDaT19I2024 TCR-T TCR-TTHLAT(TCR)TCRTHLATCR TCRCXCR3 IL-12 TGF-ß DNRTCR-TTCR-T TCR-THERV-ECMVEBV HBV HPV 20211 11T-CureHLA A-11TCR 20232 20226 2300109 20227 277320326 30 202212 319.11.415.4%202312 3110.5 202212 3136.370.2193.4%202312 31106.5 202212 31176.21.10.6%202312 31177.3 202212 3197.744.545.5%202312 3153.2 202212 31321.114.44.5%202312 31335.5 202212 31321.114.44.5%202312 31335.5 管理層討論及分析 18A.08(3) EAL® EAL®EAL®TCD8+TCD3 EAL®IIEAL®EAL®20239EAL®EAL®EAL® II4302024NDA2025 6B11-OCIK 6B11-OCIKT6B11COC166-9OC166-96B116B11-OCIK 6B11-OCIKI CAR-T CAR-T-19 CAR-TCAR-T-19CAR-T-19B(B-ALL)IND20198 202012CAR-T-19INDINDCAR-T-19I20212 25I202310III CAR-T-19II2026 RC19D2CAR-T-19-D2 CAR-T-19-DNRTGF-BCAR-T20233NMPAI20242025 aT19 aT19CD19TCD19CAR-T-19aT19CAR-TCAR-TCD19CD19CAR-TCAR-TCD19aT19CAR-T-19T aT19IINDaT19I2024 CAR-T-19aT19CAR-TCAR-TTCR-T TCR-T TCR-TTHLATCRTCRTHLATCR TCRCXCR3 IL-12 TGFDNRTCR-TTCR-T TCR-THERV-ECMVEBV HBV HPV 20211 11T-CureHLA A-11TCR 18A.05 27,60440,000EAL® EAL® • •20216 1712200,000 • •20212EAL®10EAL®48 •20225 1121,848.620 GMPGMP EAL®CAR-T-19 2023123146 EAL® EAL®II EAL®EAL® EAL®2018 9II4302024NDA2025 EAL® EAL®EAL®EAL®EAL®EAL® 84IIIc IV42EAL®42EAL®(OS)27.013.932EAL®16EAL®EAL®EAL®OS CAR-TTCR-T2023320242aT19 (ccRCC)Ct-RCC-1Ct-RCC-1e(HERV-E)HERV-E TCRTTCR-T-800 (HSCT)(SOT)(CMV)TCMVTCRCMVTCR-T-CMV TCRTCRTCR-TCMVEBVHBVHPVTCR-T GMPCAR-T 2023202212 31 202212 319.115.4%202312 3110.5 2023202212 31 b 202212 3136.3193.4%202312 31106.5Tasly Bioscience Fund, L.P. 202312 31EAL®II 202212 3197.745.5%202312 3153.2 202212 31176.20.6%202312 31177.3 202212 316.139.3%202312 318.516 202212 3113.896.4%202312 310.5 202212 31321.14.5%20231231335.5 202312 3125%201810 31202112 17202312 2015% 202212 3158.46.2202312 3152.2 20232 20300.02023220 202312 31130.3 20232(1)(2)Tan Zheng LtdTan Yue Yue LtdTan Zheng Ltd19,285,714Tan Yue Yue Ltd6,714,286 202312 31 20207 1011.00100,000,000 20207 3114,584,00014.58%TanZheng Ltd202312 31514,584514,584,000 202312 3179.8%20.2%202212 3142.4%57.6% 20232 203004.810.00120231 1168,493,1506% 202212 16 20232300.0(a)102.3EAL®2023(b)197.72025 202312 31139.1202312 31 202312 315% (1)Shaoxing Fund20212Shaoxing FundShaoxing FundShaoxing Fund (2)3.00% 202312 3121077.02022114.2202312 31 (1)(2)(a)(b)(3)202312 31202312 31 202212 310.57202312 311.05202212 310.53202312311.03 462018420198201998620046603858.SH20046201312013120158JY Research Holdings LimitedJY Research Holdings LimitedHamiyangHamiyang2015920201220237 56(i)EAL®CAR-TTCR-T(ii)(i)EAL®(ii)EAL®(iii)CAR-TTCR-T1989719921120027251992 200611200312200611201492018122018122011122015122013520175201511201512201112013122013122013820188 5820218202162021920221202311300294.SZ 60198320074020011020238600535.SH19962001 4320042012202019201620142016 692003202003300109.SZ 622020620206 29198371988719973302002920196300016.SZ202011430047.BJ 512020620206 291997112003120066201997820002Nelson WheelerNelson Wheeler199882000320091120011020061020172951201012202271430201752333 452020620206 2920026201082019252002720051220124201312201412016420167 61(i)(ii)EAL®(iii)1985219872201982023319881119897S-oil Corporation0109501991111995420061120114Pharos Vaccine20193 42200372005122010320166162006122010122010122017420162201722017420193 5320199519981998200520052016120138201612016220182 60198471987719971015Frontiers inImmunologyThe Journal of Immunology Oncogene Scientific Reports200410200992009920135 20218 23 202312 31 20233 24 20238 2520233 2420233 2420233 2420238 25 2531 18T2006 622388(2) EAL® 202312 31 2531 7475 1213 3.25C1 1213 20194 920206 6 XVXV78352 (1)LXV 5,000,000 Tan Zheng LtdTan Zheng Ltd180,480,000142,080,000Tan Zheng LtdTan Zheng LtdTan Zheng Ltd180,480,000 23,450,000 Evodevo LtdEvodevo Ltd XVXV78352 XV23336 (1)LXVSXV514,584,000(2)165,595,72197,102,57168,493,1504.8112.94%202210 30(3)20198 29Tan Zheng Ltd19,285,714(4)(BVI)53.39%(BVI)(5)Poly PlatinumPoly Platinum(GP)(GP)Poly Platinum(6)59,794,28646,080,000Tan Xiao Yang Ltd13,714,286TanXiao Yang LtdTan Xiao Yang LtdTan Yueyue LtdTan Yueyu