永泰生物-B2024年度报告

（在開曼群島註冊成立的有限公司）股份代號: 6978 24592329577274136141142144145147212 •88135 183401 20247 2620247 26202412 220247 26 20247 2620247 26202412 2202412 2 255 P.O. Box 309Ugland HouseGrand Cayman KY1-1104Cayman Islands 1816 Maples Fund Services (Cayman) LimitedP.O. Box 1093, Boundary HallCricket SquareGrand Cayman, KY1-1102Cayman Islands 17 183171712-1716 118 6978 www.eaal.net 131 20207 10 18TEAL®2006EAL®EAL® EAL®EAL® EAL®6B11CAR-TTCR-T EAL® EAL®EAL®TCD8+TCD3 II43020252EAL®20253EAL®EAL®NDA 6B11-OCIK 6B11-OCIKT6B11COC166-9OC166-96B116B11-OCIK 6B11-OCIKIII CAR-T CAR-T-19 CAR-TCAR-T-19CAR-T-19B-ALL2525CAR-T-19B(B-ALL)IND20198 202012CAR-T-19INDINDCAR-T-19I20212 25I202310III CAR-T-1925B-ALLCAR-T-19CAR-T-19 CAR-T-19II47 RC19D2CAR-T-19-D2 CAR-T-19-DNRTGF-ßBCAR-T20233 I12 aT19 aT19CD19TCD19CAR-T-19aT19CAR-TCAR-TCD19CD19CAR-TCAR-TCD19 20242aT19IINDI CAR-T-19aT19CAR-TCAR-TTCR-T TCR-T TCR-TCMVEBV CMVTCR-T-CMV20251(Pre-IND) YT007 202312 3110.523.2220.4%202412 3133.8 202312 31106.594.688.9%202412 3111.8 202312 31177.323.113.0%202412 31154.2 202312 3153.28.716.3%202412 3144.5 202312 31335.5149.144.4%20241231186.4 202312 31335.5148.144.2%202412 31187.3 18A.08(3) EAL® EAL®EAL®TCD8+TCD3 II430 20252EAL®20253EAL®EAL®NDA 6B11-OCIK 6B11-OCIKT6B11COC166-9OC166-96B116B11-OCIK 6B11-OCIKIII CAR-T CAR-T-19 CAR-TCAR-T-19CAR-T-19B-ALL2525CAR-T-19B(B-ALL)IND20198 202012CAR-T-19INDINDCAR-T-19I20212 25I202310II CAR-T-1925B-ALLCAR-T-19CAR-T-19 CAR-T-19II47 RC19D2CAR-T-19-D2 CAR-T-19-DNRTGF-ßBCAR-T20233 I12 aT19 aT19CD19TCD19CAR-T-19aT19CAR-TCAR-TCD19CD19CAR-TCAR-TCD19 20242aT19IINDI CAR-T-19aT19CAR-TCAR-TTCR-T TCR-T TCR-TTHLATCRTCRTHLATCR TCR-TCMVEBV CMVTCR-T-CMV20251(Pre-IND) YT007 18A.05 27,60440,000EAL® EAL® • 20216 1712200,000 • 20212EAL®10EAL®48 20225 1121,848.620 GMPGMP EAL® 2024123139 EAL® EAL® CAR-TTCR-T (HSCT)(SOT)(CMV)TCMVTCRCMV TCRTCRTCR-TCMVEBV GMPCAR-T CDMO 202312 3110.5220.4%202412 3133.8 b 202312 31106.588.9%202412 3111.8TCR800 202412 31EAL®II 202312 3153.216.4%202412 3144.5 202312 31177.313.0%202412 31154.2 202312 318.512.0%202412 317.516 202312 310.5323.8%202412 312.1 202312 31335.544.4%20241231186.4 202412 3125%202412 2202312 2015% 202312 3152.25.2202412 3147.0 202412 31116.5 20232(1)(2)Tan Zheng LtdTan Yue Yue LtdTan Zheng Ltd19,285,714Tan Yue Yue Ltd6,714,286 202412 31 20207 1011.00100,000,000 20207 3114,584,00014.58%TanZheng Ltd202412 31514,584514,584,000 202412 31102.9%-2.9%202312 3179.8%20.2% 20232 203004.810.00120231 1168,493,1506 202212 16 202412 18300300 20232300(a)102.3EAL®2025(b)197.72025 202412 31256.6202412 31 202412 3110.51.9% 20233 2020236 20110.020237 2020243 2020246 20202412 20103.710.020246 20 202412 315% 202412 3115470.1202377.0 202412 31 (1)(2)(a)(b)(3)202412 31202412 31 202312 310.40202412 310.20202312 310.39202412310.19202312 31124.8202412 3110.5 472018420198201998620046603858.SH20046201312013120158JY Research Holdings LimitedJY Research Holdings LimitedHamiyangHamiyang2015920201220234668120237 57(i)EAL®CAR-TTCR-T(ii)(i)EAL®(ii)EAL®(iii)CAR-TTCR-T1989719921120027251992 200611200312200611201492018122018122011122015122013520175201511201512201112013122013122013820188 5920218202162021920221202311300294.SZ 61198320074020011020238600535.SH19962001 4420042012202019201620142016 702003212003300109.SZ 632020620206 29198371988719973302002920196300016.SZ202011430047.BJ 522020620206 291997112003120066211997820002Nelson WheelerNelson Wheeler19988200032009112001102006102017295120101220227143020175202362333 462020620206 2920026201082019252002720051220124201312201412016420167 62(i)(ii)EAL®(iii)1985219872201982023319881119897S-oil Corporation0109501991111995420061120114Pharos Vaccine20193 5420199519981998200520052016120138201612016220182 20247 2620 202412 31 2328 18T2006 622388(2) EAL® 202412 31 2326 7273 1213 3.25C1 1213 20194 920206 6 202412 31 XVXV78352 (1)LXV 5,000,000 Tan Zheng LtdTan Zheng Ltd180,480,000142,080,000Tan Zheng LtdTan Zheng LtdTan Zheng Ltd180,480,000 23,450,000 Evodevo LtdEvodevo Ltd XVXV78352 XV23336 (1)LXVSXV514,584,000(2)20198 29Tan Zheng Ltd19,285,714(3)(BVI)53.39%(BVI)(4)Poly PlatinumPoly Platinum(GP)(GP)Poly Platinum(5)59,794,28646,080,000Tan Xiao Yang Ltd13,714,286TanXiao Yang LtdTan Xiao Yang LtdTan Yueyue LtdTan Yueyue Ltd6,714,286Tan Xiao Yang LtdTan Zheng Ltd(6)43,680,71441,691,428Zhang Jun Zheng Ltd1,989,286Zhang Jun Zheng LtdZhang Jun Zheng LtdZhang Jun Zheng LtdTan Zheng Ltd(7)30094.78%50.1%49.9% XV23336 20206 6 37,500,000 1.00 7 5.5 20206 662 1.2. 35,930,0006.98% a)30.00% b)10.00%10.00%50,000,000 c)(a)(d)10.00% d)(a)(c)(c) 1.00% (1)0.10%(2)5.0 10 (i)(ii)(iii) 20206 6105 202412 31(1)(2)(3)(4)(5) (i)(ii)CROSMO202412 3150.2%202349.5%202412 3119.9%202312.3% 37 16 39 1,402,498,00020231,402,498,000 20241231 36A A CAR-TTCR-T201720201. 20189 10(i)(ii)1.001.00 20189 10 (i)30(ii)(iii)30(iv) 20189 10 10 10 (i)(ii) 20189