嘉和生物-B2024年度报告

（於開曼群島註冊成立的有限公司）股份代號: 6998嘉和生物藥業(開曼)控股有限公司GENOR BIOPHARMA HOLDINGS LIMITED 年度報告 202412202412 202412202412 2024918 2024929 20249182024929 6906501-02201203 202412202412 Maples Fund Services (Cayman) LimitedPO Box 1093Boundary HallCricket SquareKY1-1102Cayman Islands •20249Candid TherapeuticsTRC 2004, Inc.KenSongGB261 20249132024107•20251242025124•2025328202542025325GB261•GB261202482TRC2004,Inc.GB2612024852024119FGFR2bIP •50%PFS(95% CI)p0.464 (0.293, 0.733)p=0.0004mPFS16.56PFS(95%CI)p0.457 (0.274, 0.761)p=0.0011 GBD218hBCMAKD=0.4nMhGPRC5DEC50 ~ 2nMCRSTCEsAEsGBD218CD3GBD218BCMAGPRC5DMMCRSGBD218(teclistamab)(Talquetamab)GBD218BCMAGPRC5DGBD218GBD218(MM) FIC/BIC(GB491, Lerociclib)GB268 INDFIH20252025HR+HER2-(GB491, Lerociclib)(HR)2HR+HER2-2025(GB491,Lerociclib)GB268 FIHGB263TEGFR/cMET/cMET 13. 1231 15.20241231 16.20244 20249122024912 5% 2023 202412319,477,833,00020239,397,851,000 (5)ArandaInvestmentsArandaInvestmentsSeletarInvestments Pte LtdTemasek Capital (Private) LimitedTemasek Capital (Private) LimitedTemasek Holdings (Private) LimitedTemasek Holdings (Private) Limited0.38% i.B+ii.Biii.Biv. 100% (j)20212021(i)(ii) i.B+100% 933(c)35 20241231 2025219 201612017720197 20241231 202412 202412 2024912 2025310 20241231 20249122024912 2024929 https://www-uk.computershare.com/Investor/#Contact/Enquiry?cc=hk&lang=zh+852 2862 855518317M ir@genorbio.com6906501-02201203+86 21 61690700 Ernst & Young27/F, One Taikoo Place979 King’s RoadQuarry Bay, Hong Kong 20241231206,229,000192,031,000 2 (b) 16120201202277 4.1 2023111.732,251,5001.73(165,000) 202312311.732,086,500 202311–––4,210,000 20231231–4,210,000 202411–4,210,000–(1,052,500) 20241231–3,157,500 20241231–– 24(a)(b)(c)(d)(e) 20241231911 (a)(b)(c) 37.7 37.8 37.11 37.12 37.15 (b) AACR ABT BDBICBICR CFDI CMC irAEs IRC 202482TRC 2004, Inc. MAH mPFS NDA 0.00002 2001116