三叶草生物-B2023年度报告

2197 235791023305976113119120121123125127203204 Trimer-Tag F(RSV) PO Box 309, Ugland HouseGrand Cayman, KY1-1104Cayman Islands Donna Marie AMBROSINORalf Leo CLEMENS 7581901 Jeffrey FARROWThomas LEGGETT 33191901 Thomas LEGGETTJeffrey FARROW Maples Fund Services (Cayman) LimitedPO Box 1093, Boundary HallCricket SquareGrand CaymanKY1-1102Cayman Islands Thomas LEGGETT 183171712-1716 2197 www.cloverbiopharma.com 202111 5 15323203-3207 97927 2023 2023F(RSV)RSVTrimer-TagRSVRSV20235202325RSV100RSVTrimer-TagRSV 2023(BLA)20232 2892023202311(BLA)RSV 202350%2024387202311 2023(CIT)2023 202212 311,856.5761.0202312 311,095.5 202312 3139.3SCB-2019CpG 1018202329 202212 3123.22,548.2202312 312,571.42023CEPI2,540.5 202312 3154.8 202212 31410.2211.452%20231231198.8 202212 311,465.3815.456%202312 31649.9SCB-2019CpG 1018CMC 202212 31593.71,218.2202312 311,811.91,697.4 202212 312,451.92,313.4202312 31138.5CEPI50% (RSV) •F(PreF) RSV•202312F(Pre-F)RSV(SCB-1019)ITrimer-Tag AdimFlu-S (QIS) •20232AdimFlu-S (QIS) •20239AdimFlu-S (QIS)AdimFlu-S (QIS)28•202311(AdimFlu-S)BLA SCB-219M •SCB-219MTPOFc(CIT)•202312SCB-219MI •28 SCB-2019CpG 1018RSVSCB-1019Trimer-TagTrimer-TagTrimer-TagICTrimer-Tag 2023AdimFlu-S (QIS)Trimer-TagI RSV SCB-1019Trimer-TagF(PreF)RSV •202312RSVF(PreF)SCB-1019IoISCB-10192024•Trimer-TagRSVRSVoPreFRSV(F)PreFSCB-1019ØV IV III II ISCB-1019SCB-1019oSCB-1019RSV ARSV BRSVoSCB-1019oSCB-1019Trimer-TagGMP(DML) AdimFlu-S (QIS) •20232AdimFlu-S (QIS)oAdimFlu-S (QIS)•20235AdimFlu-S (QIS)•20239AdimFlu-S (QIS)AdimFlu-S (QIS)28•202311AdimFlu-SBLAo SCB-219M SCB-219MTPOFc(CIT)TPOSCB-219M(ADA) •202312SCB-219MI oSCB-219M975x109/L CITSCB-219M75x109/LSCB-219M≥2SCB-219M2-3SCB-219M(SAE)(DLT) o2024IbSCB-219MCIT CTIT •282023XBB.1.5 • SCB-808 •SCB-808 202312 31145 GMP(DML)RSVSCB-1019 •20235 •(1)(2) 2023Trimer-TagRSVRSV 202312 31202212 31 SCB-2019CpG 1018202329202312 3139.3 CEPI 202212 3123.22,548.2202312 312,571.4CEPI2,540.52023CEPI20 202312 3154.8 (i)(ii)(iii)(iv)(v) 202212 31410.2211.452%202312 31198.8135.5 (i)(ii)(iii)(iv)CDMO(v) 202212 311,465.3815.456%202312 31649.9(i) SCB-2019CpG 1018CMCCDMO(ii) 202212 31593.71,218.2202312 311,811.91,697.4 (i)(ii) 202212 315.912.8202312 3118.7 202212 312,451.92,313.4202312 31138.5 202212 311,856.5761.0202312 311,095.5 202312 311,899.51,095.524.168.8697.014.1 202312 312,277.01,577.8247.8124.818.5308.1 202312 31308.13.45%7.3261% 202312 31202312 31 202312 31 100%202312 31 202312 3116.4202212 3122.15.7 202312 31343.4 202312 31387202312 31390.3202312 31 20214 1520219 26D. 63201810 3120076 •20168•20204•20176•201811 25199210GenHunterCorporation199520102007112018620217 19827199051995819971998 32202012 2520164 •2017920206•20168•20208 •20212•20204•202012•202012•20241 2014720162Centerview Partners 20145 6120213 16201112 •20162BGNE6160•200910 2001201019972010 199151984720069201382020 Donna Marie AMBROSINO7220226 17Ambrosino2020Ambrosino352022AmbrosinoInventprise(i)20211952(ii)2021Senda(iii)2020Vaxxinity, Inc.VAXX(iv)2020(v)2020CEPI(vi)2018Ambrosino Biotech Consulting, LLC Ambrosino20162019Nosocomial20142019AmbrosinoClearPath Vaccines Company LLC20122014AmbrosinoVisterra, Inc.19982011AmbrosinoMassBiologicAmbrosinoDana-Farber Ambrosino19741977Ambrosino2006Governors Award for Public Service Ralf Leo CLEMENS7120226 17Clemens2020 Clemens25(i)2022Inventprise(ii)2015CureVac N.V.CVAC(i)2020Valneva SEVALNVLA(ii)2020HilleVax, Inc.HLVX(iii)2019Icosavax, Inc.ICVX(iv)2018(v)2016(vi)2012Clemens2015GRID EUROPELTD 20122015ClemensTakeda Vaccines Inc.20062012Clemens19882006Clemens Clemens19771979Clemens190250 6220214 1920219 26 25172018520091020184 20042009200120041992 201920082018201720172017 1993419901 5920214 1920219 26 20123200812012119925200712 1987719928200310 Jeffrey FARROW6220214 1920219 26 Jeffrey FARROWTarsus Pharmaceuticals, Inc.TARS20234 24Farrow202212GlobalBlood Therapeutics, Inc.GBT2015620163ZS Pharma, Inc.20091120155HyperionTherapeutics, Inc.20085200912EvotecEVT2004120077Renovis, Inc.2008Evotec1996720041 Farrow19936Farrow20025(California Board of Accountancy) Thomas LEGGETT4720214 1920219 26 LeggettAffinia Therapeutics, Inc.Leggett20199202112Black Diamond Therapeutics, Inc.BDTXBlack Diamond2017120198Axcella Health, Inc.AXLA20155(Purdue PharmaL.P.)20091120155Leggett(UBS Securities)20071Lazard Freres & Co.2004820071(J.P. Morgan Securities)Leggett1999520045 202012 25 63201810 31 5320222 20CEPICEPICEPI(Sanofi Pasteur)(IAVI) (Oxford Brookes University)(London Schoolof Hygiene & Tropical Medicine)(University of Warwick) 6020224 (AIM Vaccine)(Sandoz China)(Gilead Sciences, Inc.)(Sanofi Pasteur China) 4320233 31 20224202042022466602012920203200712012820044200612 200272003112016920185 49202112 22Vistra Corporate Services (HK)Limited20 20071120135 13.51B(1)2023 20241 13.51B(1) 202312 31 Donna Marie AMBROSINORalf Leo CLEMENS Jeffrey FARROWThomas LEGGETT 201810 312021115 Trimer-Tag ••••••SCB-2019Cp