
24672744717394100101103104106182 108 215 15323203-3207 1 16 293-10 H 2920 1617 90711310 2509 www.qyuns.net 3485 20243 202420232023 QX002N3QX005N2QX005NQX001SHDM3001320238QX004N2QX013N 20218,000CMCcGMP * 2015QX002NQX005NQX002NIL-17A(AS)IIIQX005NIL-4RmAb(AD)20244(PN)IICRSwNPII (1)QX005NIaQX005NADIbQX005NPNIIQX005NCRSwNPII(2)QX005NADIQX005NADPNIIQX005NCSUIII(3)QX005NADIQX005NCRSwNPIIQX005NIII(4)IIIQX001SPsIII(5)20208QX001SQX001S(6)2024220QX004NPsIbII2024Ib(7)20241QX008NBLAQX008NMAHQX008N(8)20229FDAQX008NINDIaIbQX008N QX002N QX002NIL-17AIL-17AIL-17AASTNFTNFIL-17AIL-17ATNF- QX002NASLNINDQX002NASIbIIIb2QX002N160mg1620ASAS20ASAS20%ASAS40ASAS40%62.5%37.5%II4QX002N160mg16ASAS20ASAS4060.0%40.0%ASASASIII2023720239III2025 QX005N QX005NIL-4RIL-4RIL-4RIL-4IL-1322IL-4R20FDAIL-4R2023117Sanofi2024226202320-F QX005NADADPN CRSwNPCSUCOPDINDQX005NIaIbADADIb300mg600mg1275.0%-75EASI75%50.0%(IGA)01AD20232PNII20244QX005NPN20241QX005NPN20234QX005NCRSwNPII20244 18A.08(3) QX001S QX001SBLA2009FDAIL-23IL-12Ps2023109Johnson & Johnson20241232023PsIQX001SPKPsIIIQX001SPKQX001S20237BLABLA20238BLA2024QX001SQX001SPsQX001SUCCD QX004N PsCDIL-23p19QX004NIL-23p19Ps20239QX004NPsIaQX004N20231231IbIIQX004N2024202520232CDQX004NIa QX006N QX006NIFNAR1SLESLEIFNAR1SAPHNELO2021FDA10SLESLE50SLEIIITULIP-2IIb(MUSE)SLEQX006NSLEIFNAR120237IaQX006N20233SLEIb QX008N QX008NTSLPIgG1COPDTSLP2IaQX008N20238Ib9(7) (i)mAb(ii)(iii)(iv)(v)919IND18FDA1CRO11960% 20231231364.4 CRO20221220QX002NQX005NCROQX002NASIIIQX005NPNCRSwNPIIQX005NPNADIII cGMP2019GMP57,97742,000L300kg2ml10ml30ml18,0001ml2ml9,000QX001SQX002NQX005NBLA2023123113221222cGMP 39327950QX002NQX005N83152120231231 20231231331 2022915 20231231222.420221231117.3 20231231 ••CMC••• 20231231 20222023 202225.73.1%202324.920236.24.4 202214.4202220230.4202312023 202276.62023164.6(i)202210202367.4(ii)12.1 2022257.241.7%2023364.4(i)CRO85.6(ii)22.32022102023 202218.710.0%202316.820236121.8 2022202373,000 202220232023521.32022312.3 20221231513.820231231166.6(i)2023240.73.22023(ii)70.0CRO 202312314.9QX001S 2022123118.444.0%2023123126.56.8CRO 2022123159.920231231129.9CRO53.8 202312310.9CDMO 202312312022 QX001S 202220231231293.0344.12023123159.6202215.9202312313.3%4.2%20224.3%20222023123118.616.8 202212315.2202312311.7(i)2023240.73.22023(ii)70.0CRO 100%2023123142.5% 20231172023811 202312311212 20231231 202312315% 2023123118 20231231 522015652023323201562021920222 (i)20187(ii)2018820233 301993720041(i)11hIL-1111(ii)2004220056(i)(ii)20051220151 (i)2005720151(ii)2007820151(iii)2008720151(i)2(ii)(iii)B(RANKL)(iv)20096 1993720056200520062 42201941020233232015620233 15201562015620191QX001S2019220232QX002NQX005N QX004N QX006NQX008NIII2019320232 2007720153(i)2008720105(ii)2010520155500L 2003720069201312 412022316202332320218202182021920219 13200410200562005112009122010(i)2010520125Arkema S.A.AKE(ii)20131220156Imerys S.A.NK(iii)20162201610(iv)20161120183(v)2018920193(vi)2019620201202142 200472016620132 5020208142023323 JNJSanofi S.A.SANSYN20189201912202011000963 19977 (i)B+QX001S202058202011B+QX001S (ii) (iii) (iv) 4220219172023323 132007122010660137720115201711(i)2012120125201511201612(ii)2013520187(iii)2015112016122019920148 20046 3720213292023323 20161020187201872020920209Matrix Partners China 20081120161 59202414 3219847198791990819927199271995919987200522005220211120059202111 198471990819987200920132 55202414 231994819999200420112011420231 198871994720043202012 55202414 301992819999•199910200782008120108391820111202212(i)20111201472098(ii)20147201740295(iii)201752022123718 20174(i)2017420238GEM8452(ii)201762021101695(iii)2020103913(iv)2021110672(v)2023102473(vi)2023122419 199210200110(ACCA)20059 512021917 2014122020120201 199572002619995 362022915 201722019320194TMT20229 2009720171 422021917201842021420214 20156(i)2015620208(ii)20156201842018420214(iii)20214 20067201532008720153 200362006620159 63202010142020102023220233GMP 14GMPSymyx Technologies Inc.APISMMXSyagen Technology Inc.Smiths Group plcSMIN20078201411Allergan, Inc.AbbVie Inc.ABBV2016420208Sorrento Therapeutics Inc.SRNE 19821019885199312University ofBerne 502023213 20131PFE20141220171201892020620228600422 1995720079Simon Fraser University 4820171224202142023220233 Merck & Co., Inc.MRK20121120146GSK plcGSK2015120159616020151020174(PDSP)0235960325920174201710 2000720038University of Twente 36202011202282023322 2012820189201810202010 2009620127 36 2023322 10 239199876959 20117202111 20231231 20231231 20156162021930H2024320 13 2023 20231231 325 2023123179.5202255.028.4%202227.4%2023123133.5202224.311.9%202212.1% 202312315% 20%18320% H[2008]897H200810% 20231231HHHH 202312317.9202222.82023123111 2024131269.7178.020231231 20231231 20231231 2023123126 20231231 20231231 622 2023123120221231 2023123122 20231231 101144 2743 2023123120231231 000963 (a)(i)(ii) (b) (c) (d) 20231231 3D 20231231 20231231 13.2013.21 13.22 202