金斯瑞生物科技2023年度报告

(i)(ii)CDMO(iii)(iv)CDMO 2468912364780100106107108110112114 (i)(ii)CDMO(iii)(iv) 21 (i)(ii)(iii)(iv)48.2%12.7%5.1%33.9% 1006,937 DNA87,745 CDMO TT(NK) 100506.0162.599.553.218.360.2%19.4%11.9%6.3%2.2% 1531 97927 4th Floor, Harbour Place103 South Church Street, George TownP.O. Box 10240, Grand Cayman KY1-1002Cayman Islands 383 Madison AvenueNew YorkNY 10017U.S. 28 88 860 Centennial AvenuePiscatawayNJ 08854U.S. www.genscript.comwww.genscriptprobio.comwww.legendbiotech.comwww.bestzyme.com 24840 — 1548 Harneys Services (Cayman) Limited4th Floor, Harbour Place103 South Church StreetGeorge TownP.O. Box 10240, Grand Cayman KY1-1002Cayman Islands 183171712–1716 •839.5625.734.2%554.5509.08.9%285.0116.7144.2% •409.6304.134.7%270.6257.15.3%140.951.6173.1% •428.0355.1 359.4298.258.162.4356.6422.1 •226.995.5 (2)(i)(ii)(iii)(iv)(v)(vi)(vii)(viii) ••CDMO•AI•CARVYKTI1,000 CARVYKTICARVYKTIFDACARVYKTI2–4CARVYKTI (i)(ii)CDMO(iii)(iv) 1006,937 DNA87,745 CDMO TT(NK) 100506.0162.599.553.218.360.2%19.4%11.9%6.3%2.2% 839.5625.734.2%409.6304.134.7%(i)(ii)CARVYKTI 355.1428.0298.2359.4 95.5226.9 (i)(ii)(iii)(iv)48.2%12.7%5.1%33.9% (i)(ii)(iii) DNADNA(IVT)RNACRISPRsgRNA(cGMP)(HDR)DNA(ssDNA)DNA (dsDNA)dsDNA 412.9360.514.5%224.5201.111.6%55.8%54.4%78.365.619.4% (i)CGT(ii)(iii) DNARNACDMO 109.5125.012.4%19.842.853.7%34.2%18.1%29.71.1 (i)(ii)(iii)(i)(ii)(iii)mRNA (i)(ii)(iii)(iv) 43.138.711.4%16.642.9%38.5%2.02.416.7% (i)(ii) (i)(ii)(iii) CARCAR-TBBCMACAR-Tcilta-cel Janssen-Cilag International N.V.JanssenCARTITUDE-4 (NCT04181827)EMACARVYKTI®IICARTITUDE-4CARVYKTI®1–3 FDACARVYKTI®1 3(DLL3)TCAR-TLB2102 2023ASH3CARTITUDE-4CARVYKTI® FDACARVYKTI®cilta-cel CARVYKTI® 285.1117.0143.7%143.953.0171.5%cilta-celCARVYKTI 394.5422.1cilta-cel356.9316.691.190.489.868.7 CAR-TCAR-NKCAR cilta-celCAR-T(NHL)(ALL)BCMACAR-TIBCAR-NKFDA 839.5625.734.2%(i)(ii)CARVYKTI 304.134.7%409.6CARVYKTI29.6% 168.33.6%174.34.9% 182.516.9%213.4(i)(ii)(iii)20.2% 390.110.9%432.8(i)(ii)cilta-celcilta-cel 3(iii)10.3% (i)14.4162520,809,850(ii)10,000,000300.020.0 200.010,000,00085.8 Probio CaymanProbio Cayman300,000,000Probio Cayman AProbio A189,393,939Probio CaymanProbioProbio CaymanProbioCayman150.0ProbioCaymanProbio125.0Probio Cayman Probio CaymanProbio Cayman319,998,370ProbioCayman CProbioC224.0Probio C Probio AProbio CProbio ProbioAProbioCProbio350.2129.2 Probio CaymanProbio Cayman57,314,000Probio Cayman BProbio B37.3ProbioBProbioB ProbioB 37,609,0705.3250.035.210.4168%AA A Probio B1.6Probio B39.02.2A36.41.2 4.13.7 355.1428.0298.2 17.916.58.5% 608.1521.616.6% 18.623.821.8% 120.6103.117.0% 141033.127.2 373.9146.9 286.9 357.7(i)256.5(ii)93.4(iii)174.4(iv)20.6 11(i)783.4(ii)Probio Cayman194.0(iii)35.1(iv)49.8(v)17.7(vi)9.5(vii)2.2 4.198.8153.6 1.4%5.9%12 (i)(ii) — 75.043.0A–AA–A132.0J.P. Morgan Structured Products B.V.A+AAAa2 5.20%5.35%5.80%5.92%(i)(ii)(iii) (b) *AB 1414.071.0% 4.42.4 Probio Cayman Probio CaymanProbio Cayman319,998,370Probio C224.0Probio C Probio CaymanProbio Cayman 37,609,0705.3250.035.210.4168%A (i)26.1252.247,656,968(ii)26.1252.24484,992(iii)64.05,468,75010,937,500(iv)32.064.0692,782 GenScriptJapan Inc.GS10.071,000(TIBOR)0.25%GS GS94.013.32.4%GS50.07.12.5%GS GS121.217.11.4%1.7% 23.73.41.4%1.5% 10.01.42.6% 72.410.21.5%1.7% 10.01.42.6% 41.65.94.2% 22.03.11.1% 250.017.353.149.35.360.960.53.631.3 12(SOFR)LIBOR/SOFR122.5% 128.3GS10.071,000 35.75.041.65.9 357,00023.19.7 236.333.4BProbio Cayman 4.83.239.6%46.5% CGTGMP GMPGMP MM IT 60.022.0 117.5 500.6 501.3 26.127,656,968 26.12484,99232.00692,782 64.005,468,75010,937,500 LGN Holdings Limited10,000,00020.00200.0LGNHoldings Limited10,000,000 CARVYKTI II15.020.0 3(DLL3)TCAR-TLB2102110.1 Genscript CorporationGS Corp8,578,000156,119,600 CGTCAR-TCGTCGT 20100 CDMOCDMOCDMO CDMO(i)(ii)(iii)(iv) 6,937 449.853.6% ProbioCaymanProbioCaymanProbioCayman 59GenscriptCorporationGSCorp(NASDAQ:LEGN)GenScriptBioscience(BVI)Limited Genscript USA IncorporatedGSUSAGenScriptUSA Holding,Inc.CustomArray,Inc.GenScript(Hong Kong)LimitedGSHKGenScriptBiotech(Singapore)Pte.Ltd.GenScript Biotech (Netherlands) B.V.Genscript Biotech (Spain), S.L.Bestzyme Biotech LimitedBestzyme USA Inc.Bestzyme Biotech HK Limited Bestzyme Hongkong Limited Bestzyme Biotech Inc.LegendBiotech Limited Legend Biotech HK Limited Legend Biotech USA Inc.Legend Biotech IrelandLimitedLegend Biotech Belgium BV Yangtze Investment (BVI) Limited Yangtze Investment USA, Inc.Yangtze Holdings (BVI) LimitedYangtze Investment (HK) Limited Curegene Biotech Corporation CuregeneBiotech (BVI) LimitedCuregene Biotech (HK) Limited Probio Technology Limited 26G- (Duke University) 55ProbioTechnology I LimitedProbio Technology Limited Probio Technology (BVI) Limited 29***(Schering-PloughChina)(Saint-Gobain Grains and Powder Division)Quay Magnesium 55GenScript Bioscience (BVI) LimitedGenscript Biotech LimitedGS HK, GS USABestzyme Biotech LimitedBestzyme B