Enable Precision in PatientRecruitment with Citeline PatientMatch Citeline PatientMatch is an AI- and real-world data-driven solution that helps sponsors identify highly qualified,protocol-matched patients earlier in their care journey — when enrollment decisions matter most. By leveragingmedical and pharmacy claims, laboratory results, electronic health record (EHR) data, and provider-dictatedclinical notes with advanced natural language processing (NLP), Citeline PatientMatch enables sponsors and sitesto surface eligible patients with greater precision and speed, accelerating enrollment and reducing site burden. Why Citeline PatientMatch Enable Precision in PatientRecruitment with Citeline PatientMatch What Makes Citeline PatientMatch Different Citeline PatientMatch leverages multiple proprietary datasets and large-scale real-world data (RWD) to accuratelyidentify patients who precisely match your study protocol. These include: Proprietary data assets, including the Skipta network of 2M+ providers, along with Trialtrove and SitetroveLongitudinal real-world datato identify prospective patients earlier in their care journeyOpen and closed claimsfor insight into diagnoses, treatments, and care pathways among patients inthe USLab data from leading national reference labs, delivering early, objective clinical signalsEHR data, both structured and unstructured, that includes billions of clinical notes and physiciannarratives which are analyzed using advanced clinician-reviewed NLP resources Together, this providesvisibility at the provider, disease, and patient level, enabling a complete picture of thepatient journey and highly specific protocol matching. Scale and reach 177M+ 500M+ Connected to 3 of the top 4national referencelabs and400+hospitals andhealth systems clinicaltransactions Connected, Privacy-First Data Citeline PatientMatch securely links de-identifiedpatient records to the national provider identifier(NPI) of every healthcare provider, principalinvestigator, and healthcare institution, allowingsponsors to understand which patients match theirstudy protocol and where they are receiving care. Enable Precision in PatientRecruitment w ith Citeline PatientMatch NLP for Deeper, More Accurate Matching Citeline PatientMatch uses NLP to analyze bothstructured and unstructured RWD: Unlocks insights hidden in clinical notes, pathology reports, and EHR narrativesIdentifies patients whose eligibility factors may not be captured in ICD-10 codes or standard structured fieldsEnhances precision for complex, biomarker-driven, rare disease, and oncology protocols Scalable & EHR-Agnostic Deploys seamlessly across any EHR ecosystem and supports national-scale recruitment How Citeline PatientMatch Works Algorithm Creation1 A tailored, clinically robust algorithm is developed using defined data specifications to reflect the keyinclusion and exclusion criteria of your protocol. Continuous RWD Monitoring Citeline PatientMatch then monitors lab results, claims, EHR activity, and clinical notes for data definedin the clinical algorithm to surface protocol-aligned patient activity in near real time. Curated Alerts Delivered to the Right HCPs Four alert types ensure the right stakeholder is notified quickly: Principal Investigator (PI) alertsHCPs located at PI study siteAffiliate HCPs working at clinics and hospitals directly affiliated with the PI study siteGeo-targeted HCPs working at non-affiliated clinics and hospitals in the surrounding area Alerts include de-identified, actionable details to guide rapid site follow-up without overwhelming siteswith inaccurate and inapplicable referrals. Transparent Reporting A real-time dashboard provides visibility into alert volume, demographics, site performance, andreferral progression. Enable Precision in PatientRecruitment with Citeline PatientMatch Impact You Can Expect Earlier identificationof highly qualified,protocol-matchedpatients Reducedscreening burdenand lower screenfailure rates Fasterenrollmenttimelines Increased siteengagement and morepredictable recruitmentperformance More efficient useof sponsor andsite resources Optional Enhancementsto Maximize Performance Nurse-led HCP EngagementHCP Pull-Through ServicesDirect-to-Patient Outreachvia diagnostic partnersSite Platform Integrationvia OneStudyTeam (OST) Unlock Precision inPatient Recruitment Citeline PatientMatch ensures you never miss arelevant patient — delivering the insights, accuracy,and speed needed to meet critical study timelines. Learn more aboutCiteline PatientMatchorrequest aProtocol Assessmentto understand potential patientcoverage and expected recruitment impact for your trial. Citeline, aNorstellacompany, powers a full suite ofcomplementary business intelligence offerings to meet theevolving needs of life science professionals to accelerate theconnection of treatments to patients and patients to treatments.These patient-focused solutions and services deliver an