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How Smart Patients Advisers Helped InformCiteline Connect Content Case Study| Patient Input in Clinical Trial Recruitment Overview Clinical trial patient recruitment remains a thorny problem for many sponsors. One reasontraditionally cited is patients’ lack of willingness to participate. Not all statistics bear thisout, however. For example, 91% of respondents in the 2023 Perceptions & Insights studyfrom the Center for Information and Study on Clinical Research Participation (CISCRP) saidthey were at least somewhat willing to participate in a clinical trial.1 Clearly, there is a disconnect between patients who want to participate in clinical trials andthe sponsors who run these trials. One way to bridge this divide is to connect with patientswhere they are looking for study information — and increasingly that is online. Accordingto CISCRP’s 2023 study, aside from speaking with their doctor, more than one-third ofrespondents said their first step in identifying a clinical study that is right for them would beto conduct an online search.1 To continue narrowing the gap between patient candidates and clinical trial sponsors,Citeline engaged Smart Patients’ Virtual Patient Advisory Board (vPAB) panel to gainpatient insights on its Citeline Connect patient engagement and recruitment solution. ThevPAB consultations involved sample versions of Citeline Connect’s IRB-approved outreachmaterials and three of its Clinical Trial Portfolio Websites. Case Study| Patient Input in Clinical Trial Recruitment Part 1:Citeline Connect Patient Engagement Research methods included focus groups and surveys involving patients diagnosed withchronic illnesses. The advisers on the vPAB were asked about their experiences with sampleversions of Citeline Connect’s clinical trial outreach, including their preferences in imageryand wording. By gathering this feedback, Citeline sought to understand patients’ preferences andexpectations regarding clinical trial communication in order to enhance the design andfunctionality of Citeline Connect’s IRB-approved outreach materials. Insights Images •Patient advisers discussed whether images of real individuals, models, or actorswere a crucial factor in establishingauthenticityandtrust.•They examined images forrelatabilityandspecificity, as well asbalanceinterms of emotions referenced in conveying information.•They suggested which graphics were moreeye-catching, especially in waitingrooms and doctors’ offices. Tone •Patient advisers gave feedback as to what tone helpedempowerpatients.•They discussed whether a call to action was recommended toencouragepatients toexploreclinical trial opportunities further. Language •Patient advisers discussed what made up aclearandconciseexplanation of thestudy’s purpose and goals, along with information about why individuals shouldconsider participating.•They advised as to what constitutesaccessiblelanguage and how manyrequirements to include in recruitment materials. “… If I had condition X and were browsing online for information about itand came across a link that used the word ‘study’ or ‘trial’ or the name of mycondition, I would want to click on it…. I would be further intrigued by the wordingto ‘see if I qualify’ because that would pique my interest. I have joined studies andtrials or at least looked for further information by such means, especially if I readthat said study was coming from a known teaching and research hospital.” — SMART PATIENTS ADVISER Case Study| Patient Input in Clinical Trial Recruitment Identifying study sponsor •The vast majority (90%) of advisers expressed a desire to know the name of thestudy sponsor, citing it as a critical factor in their decision to participate. Thistransparency was instrumental in buildingtrustandcredibilitywith potentialparticipants. Preferred contact methods •The advisory group ranked preferred methods of being contacted about trials,with healthcare professionals (HCPs) being the first choice among the majorityof patient advisers. Part 1 Conclusion The insights gathered from patients through the Smart Patients vPAB were instrumentalin shaping Citeline Connect’s IRB-approved outreach materials. By prioritizing patientperspectives, Citeline ensures that recruitment content is not only patient-friendly butalso deeply resonates with potential participants. This patient-led approach reflectsCiteline’s commitment to making clinical trials more accessible and impactful, ultimatelystrengthening recruitment by addressing real patient needs and preferences. Case Study| Patient Input in Clinical Trial Recruitment Part 2:Clinical Trial Portfolio Websites PatientEngagement and Search Experience Citeline sought to elevate patient engagement and optimize the usability of its TrialPortfolio Websites by engaging a Smart Patients vPAB to conduct a comprehensiveevaluation of several websites and their search functions. The overarching goal of gatheringthis feedback was to confirm the functionality and