来凯医药-B：截至2025年12月31日止年度的年度业绩公告
2105 20251231 2025123120241231 20251231 LAE102I LAE102ActRIIAActivin-ActRIILAE102 20251LAE102ISADA40B24LAE102TEAETEAELAE10224A (Activin A)Activin A2823PK/PDLAE102IMAD20256ADA85 20253LAE102IMADMADLAE102MAD(BMI)29.4 kg/m25LAE102 6 mg/kg1.7%2.2%4.6%3.6%LAE102ISADMADTEAE1LAE102PKSADPK/PDLAE102 MADLAE102202512ILAE10260LAE102 20263LAE102ISADLAE102SADSADLAE102295.06%1.34%0.12%2.11%LAE102 LAE102ActRIILAE103ActRIIBLAE123ActRIIA/IIBLAE102LAE103ActRIIBLAE123ActRIIA/IIBADA85 20257FDALAE103IND202512LAE103ILAE103 SADLAE103 SADLAE103SAD2026LAE102LAE103ActRII LAE123IND2026INDActRIIActRII LAE002 (afuresertib)+HR+/HER2 -III 20245LAE002afuresertibAKTPIK3CA/AKT1/PTENHR+/HER2-LA/mBCIIIAFFIRM-205IIIAFFIRM-205IIIAFFIRM-2052025122026III 20262•AfuresertibHRHER2IbIbafuresertibHRHER2 LAE 002 (afuresertib)HR+/HER2-III(AFFIRM –205)NDA5.320.45LAE 002 (afuresertib)LAE002 (afuresertib) LAE002 (afuresertib)+LAE001mCRPC, II 2024LAE002afuresertibAKTLAE001CYP17A1/CYP11B2LAE20140SOCmCRPCIImCRPCrPFS8.1mCRPC24rPFS FDALAE201SOCmCRPCIII20245FDAIIILAE002 (afuresertib)LAE001 (PCC) LAE123ActRIIA/IIBIND2026IND 2026LAE124AmylinPCC 20262PI3KLAE118PIK3CAFDAIND202542025LAE002 (afuresertib) USP1LAE12020252FDAIND 2026 LAE102 •IMAD•GLP-1II AFFIRM-205 •IIIAFFIRM-205•CDENDA •LAE103ISAD•LAE123IND•LAE124AmylinPCC 20251231 (253,706)(242,949) 8(0.59)(0.71) 20251231 20251231 (92,822)(278,303) 1 2016729 2023629 2 20251231 20251231 3 (IASB)21— 4 (a) 20251231 (i) 123120252024 88,702–18,017– —88,702–—18,017– 10% 123120252024 106,719– (ii) 2025123134,791,000202412 (b) 8 20251231106,719,000 5 6 (a) (i) (i) (ii)20251231101,014,000202483,459,000 (iii)202512313,429,0002024 7 (i) (ii) 16.5%202520241231 (iii) 21%0.75%9.00%20240.75%9.50%202520241231 (iv) 25% 20233202311100% 8 229,318,0002024254,296,000388,983,0002024357,626,000 202520241231202520241231 202411 (i)LAE001 2017630Novartis Pharma AGLAE001 16.6776,4377,764,3701.812.220251231LAE001 (ii)LAE002 (afuresertib)LAE003 201859LAE002 (afuresertib)LAE003 531.9165,2001,652,0005.233.5 2025LAE002 (afuresertib)2025 (iii)LAE005 202024LAE005 1069.420251231LAE005 (iv) 2035 202520241231 10 20251231404,400,0002024B259,738,000 12 20252024 202512 312.37%3.85%20243.20%4.10% 14 202512312024 20251231591130 20251231LAE102LAE103 LAE002 (afuresertib)LAE001LAE005 2030111— SOCHR+/HER2-HR+/HER2-mBCmCRPCPROC(TNBC)SOC 20251231 LAE102I LAE102ActRIIAActivin-ActRIILAE102 20251LAE102SADA40B24AB29.031.2(BMI)23.32kg/m²23.08kg/m²LAE102TEAETEAE LAE10224A (Activin A)Activin A2823PK/PDLAE102MAD20256ADA85 20253LAE102IMADMADLAE102MADBMI29.4kg/m²355LAE102 6mg/kg1.7%2.2%4.6%3.6%LAE102ISADMADTEAE1LAE1025PKSADPK/PDLAE102 MADLAE102202512ILAE10260LAE1026 20263LAE102ISADLAE102SADSADLAE102295.06%1.34%0.12%2.11%LAE102 LAE102ActRIILAE103ActRIIBLAE123ActRIIA/IIB LAE102LAE103 ActRIIBLAE123ActRIIA/IIB20256ADA85LAE102LAE103LAE123AB AB(MSTN)EGDF3LAE102LAE102LAE103ActRIIA/IIBLAE123ActRIIALAE102LAE123ActRIIAActRIIB 20257FDALAE103IND202512LAE103ISADLAE103SADLAE1032026SAD LAE123IND2026INDActRIIActRII LAE002 (afuresertib) Afuresertib(ATP)AKT2018AfuresertibAfuresertib11 LAE002 (afuresertib) +HR+/HER2 -III 20245LAE002afuresertibAKTPIK3CA/AKT1/PTENHR+/HER2-LA/mBCIIIAFFIRM-205IIIAFFIRM-2052025122026IIINDA 20262•AfuresertibHRHER2IbIbafuresertibHRHER2 LAE002 (afuresertib)HR+/HER2-IIIAFFIRM-2055.3 20.45LAE002 (afuresertib)LAE002 (afuresertib) LAE002 (afuresertib)+LAE001mCRPC, II 2024LAE00240SOCmCRPCIImCRPCrPFS8.1mCRPC24rPFS FDALAE201SOCmCRPCIII20245FDAIIILAE002 (afuresertib)LAE001 LAE001 LAE001CYP17A1CYP11B22017LAE001LAE001CYP17A1/CYP11B2CYP17A1/CYP11B2 LAE001ILAE001LAE002(afuresertib)mCRPCIIFDA20245LAE201SOCmCRPCIIILAE001 LAE005 LAE005PD-L1IgG4LAE005PD-L1LAE002 (afuresertib)LAE005(TNBC)LAE005TNBC LAE002 (afuresertib)LAE005 (anti-PDL1mAb)TNBCI20244AACR22I14TNBC21141.5(0-3)5(ORR35.7%)4(28.6%)(DCR)64.3%(DOR)9.26TNBC32732023928PFS16LAE005 2025106.7LAE002 (afuresertib) 202520.3IIIAFFIRM–205 202438.26.717.5%202544.9 202474.132.443.7%2025106.5 2024215.134.816.2%2025249.9ActRIILAE102LAE103LAE123 202512311,272.61,243.219.210.220241231636.4606.895.3%202512311,243.220241231163.62025123119.220251231229.675.4117.434.82.0 202512311,262.4109.21,152.01.220241231800.057.8%20259 202520241120259 20251231117.42024123199.02.37%3.85% 202512315.54202412315.48 100%20251231 20251231 2025123120251231 202512314.1 20251231832025188.82024134.7 20236920246142024 202362912.410.0000163,728,000724.4 20251231 (1) 202411272024112113.3617,636,000235.6230.420241121 (1) 202591716.3036,000,000586.8577.52025910 (1) LAE102ActRIIAActivin-ActRIILAE102LAE103ActRIIBLAE123ActRIIA/IIBActRIIActRII LAE002 (afuresertib)CDK4/6HR+/HER2-LAE002 (afuresertib)LAE001A/ARmCRPCmCRPC LAE102202511LAE002 (afuresertib) 2026LAE124AmylinPCC20262LAE118PIK3CAPI3KFDAINDLAE002 (afuresertib)LAE118 C1C.2.1 C.2.12018520174 202591736,000,00016.308.06% 16.30(i)20259918.019.50%(ii)16.984.0% 586.8057
