瑞科生物-B：截至2025年12月31日止年度的全年业绩公告及建议变更募集资金用途

Jiangsu Recbio Technology Co., Ltd.2179 20251231 2025123120241231 REC610 (VZV) 20254REC610401824,640REC610202512 REC603HPV HPV90%90%HPV HPV202511542025HPVHPVHPV 20251231 (610,390)(562,389)–492 (610,390)(561,897) (258)895 (610,648)(561,002) (610,648)(561,494)–492 (610,648)(561,002) 10(1.15)(1.16) 20251231 2025202412311231 538,249839,420 2025202412311231 517,747571,488 705,838529,324 705,838529,324 1. 888 2022331 2. 20251231 (a) (b) (c) 2. 2025123187,000 (1)2 0 2 632 4328,550,000195,547,00020261231(2)(3) 2025123112 3. 221 1819979710282111 1 321791071 120261122027113 3. 18111818818733341820271118 19101919 97 9797 3. 102810281028 212934 111779107 •77B387IG1IG14IG20B77 •9993.3.316995.1.39A •1010B7410B73 •7737 4. 10% A 5. 20252024 12,726– * 12,726– 10,933–1,793– * 5. (b) 30 20252024 10,802– 20251231 6. (a) * 6. 7. * 8. 9. (a)25% (b)25%202212302022202515% (c) (25%) 9. (c) 202520241,109,573898,94168,21781,3131,177,790980,254 2025202412314,747,986,0003,905,598,000 10. 531,235,9992024478,540,929 20252024 11. 2025202416,27241,60369318,18616,96559,789 13. * 14. 20251231 ***202843,900,000***20279 15. 2024 2012HPV10REC610REC603HPVIII FDAIPDOPTI10 (WHO PQ)HPV2,000HPVHPVBLA202111CHO(QP)17,000CHO HPV10REC610(IIIREC603HPV 1. 2.HPVREC60320187INDIIIIREC603III 3.HPV(REC604a) 4.REC6102023102023LP021513.3IIII202410III 5.ReCOV 6.REC6252025 7.HPVREC604c REC610 REC6102023102023LP021513.3IIIIIIIREC610REC610401824,640REC610Shingrix®40REC610SAEAESITEAEREC610gEShingrix® 1)REC610SAEAESITEAEREC610Shingrix®TEAETEAETEAETEAE1213REC610≥5%TEAE 2)REC610gE30Shingrix®Shingrix®REC610REC610Shingrix®60230gEgEGMTGMISCRREC610GMTGMIREC610Shingrix®60230ICS12gECD4+TCMIREC610Shingrix® (VZV)REC610BFA01VZVE(gE)CD4+T40407Shingrix® 18A.08(3) HPV HPVHPVHPV16183133455258HPV90%HPVHPVHPV REC603IIIHPV REC603HPV61116183133455258REC603III4854 20187REC603INDIIII HPVIIIREC603IIIGardasil®916,050REC6034854INDREC603 REC603REC603 REC603IHPVNAb GMT HPVREC603HPVHPV REC603IREC603HPVHPV2009Merck Sharp & DohmeGardasil®986.6%REC603I53.75%1 HPVREC603 HPV HPVHPV90%90%HPV20256HPV®9HPV 1 HPV2016HPV201966.7%HPVHPVHPV20192019-2022HPVHPVIIIHPV 2022830HPV9452021REC603III945 HPVHPV HPVIIIHPVIIIHPV 18A.08(3) REC601I(16/18)HPV HPVHPV HPV1618HPVREC601IIREC601945430HPV1618100%100% HPV1618HPV16GMT632.99HPV18GMT1,194.02REC601HPV REC602I(6/11)HPV REC602HPV6/11HPV2022IREC602HPV REC604aREC604cHPV HPVREC604aREC604cHPVMerckGardasilCervarixAS04HPVREC604aREC604cREC604aHPVREC604cREC604c REC625 REC625REC625B ReCOV ReCOVBFA03 REC609 REC609 REC629 HPVREC629 REC630 HPVREC630 REC608 REC608 REC617 REC617 21AS01AS03 AS04 CpG1018MF59FDA20FDABFA01BFA03CEPI CHOHPV 2004ELISPOTICS 20100 IPDIPDIPDIPD 2025AI IPDIPMT 20251231520.7 4,0003,0003,800HPV HPV2,000HPV GMP(QP)CHOHPV2025 HPVBiological ENanolekHPVREC603Biological ENanolek 41751142HPVSARS-COV-2(RSV)4030520251231 2025123149120251231190.420241231187.9 •••• •HPV•••BD• 202412312025123112.7 2024123161.666.46%2025123120.718.68.711.0 202412312.640.31%202512311.6 20241231476.19.37%20251231520.7 •20241231154.57.620251231146.9REC603/REC610III •2024123173.426.52025123199.9HPV 20241231109.116.13%2025123191.4 2024123116.984.97%202512312.53.99.1 2024123118.926.77%2025123124.0 (i)(ii)(iii)(iv)(v)(vi)202412311,054.84.04%202512311,012.2 (i)50HPV(ii)2024123134.616.11%2025123140.213.2 20241231149.013.12%20251231129.4HPV19.3 20241231136.36.15%20251231144.7 20241231456.522.93%20251231351.8 2024123159.871.63%2025123117.0 20241231269.48.02%20251231247.8 2024123110.873.29%2025123118.813.2 20241231456.520251231351.8351.399.8%0.10.0%0.40.2% 20241231(184.3)99.96%20251231(0.1) 20251231201.220241231169.2 20251231619.7249.920262.50%6.70%369.82027-20282.50%6.07% 202412310.78202512310.99 2025123159.9%2024123172.7% 20251231 (i)(ii)(iii)(iv)(v)(vi)20241231171.820251231104.0 20241231381.820251231315.4 20251231 2025123150202512313,294,00020242,739,000 20251231 20251231 20241111143,112,70220241111143,112,7025.595.521.00143,112,702202412242025723[2025]15062025121720251215143,112,702626,075,702297,937,01312,000,000316,138,689H 800,000,004 (i)70%5.631%31%8% (ii)30%2.4 10,014,637.15789,985,366.85 20241111H8.24 20241111202412242025192025227202572320251016202512172024125 H 2025521141,953,489HHHHH 2025618HH2026113202625141,953,489HHH H20255212026130202626 2025121202512192025122313.92(2)B.3.5 20251223202520261C.2.7 C.2.120251223 (i)(ii)(iii) 2025122320251223C.2.1 2022331H2022423669,7142023320202332020251231669,7140 20251231 2024123120252025123120251231(%) 2024123120252025123120251231(%) 2024320(i)(ii)20251231 20251217789,98520251231475,169314,816 20251231 REC610HPV9REC603314,816700315,516177,560REC61076,630HPV9REC60361,326 (1)REC610(BLA)BLA (2)HPV9REC603IIIIII (3) 2026324 202612 202512312024 20251231202512312025123120251231 H 20265222026528HH2026528H2026521H183171712-1716H