瑞科生物-B：截至2024年12月31日止年度的全年业绩公告及建议委任董事会观察员

Jiangsu Recbio Technology Co., Ltd.2179 20241231 2024123120231231 REC603HPV HPV90%90%HPVHPV REC603III36422025BLA 20237HPVIIIHPVIIIHPV REC610 (VZV) IIIREC610401824,640REC610Shingrix®40REC610SAEAESITEAEREC610gEShingrix® REC625 REC625REC625B2025 ReCOV ReCOVBFA0320214ReCOV2023mRNAmRNA GMP(QP)REC610REC625 20241231 (561,897)(572,443) 8952,421 (561,002)(570,022) (561,494)(569,536)492(486) 20241231 2024202312311231 1,285,1031,056,904 655,1291,129,373 (184,291)685,138 1,100,8121,742,042 571,488671,098 529,3241,070,944 –(492) 529,3241,070,944 1. 888 2022331 2. 20241231 (a) (b) (c) 2. 20241231184,291,000 20241231200202641 14620251231 2024123112 3. 16120201202277 (a)1616 (b)2020202212 2023202411 (c)77 4. 5. (a) (i) (b) 6. 7. * 8. (a)25% (b)25%202212302022202515% (c) 2024202312313,905,598,0003,063,726,000 9. 202420231231202211 20242023 10. 2024202341,603113,91818,1861,16359,789115,081 319,040834,983 319,040834,983 20242023 129,275– 129,275– 45,890–83,385– 129,275– 13. 20241231 ***202793,900,000***20279 14. 2023 2012HPV10REC603HPVIIIREC610III FDAIPDOPTI10 (WHO PQ)HPV2,000HPVHPVBLA202111CHO(QP)17,000CHO HPV10IIIREC603HPV 1. 2.HPVREC60320187INDIIIIREC603III20241111HPV20258312026228HPV202512312026630HPV202612312027630 HPV(REC604a) 4.REC6102023102023LP021513.3IIII202410III2024111120259302026331202512312026531202611302027531 5.ReCOV20214ReCOV2023 6.REC6252025 7.HPVREC604c20252(IND) HPV HPVHPVHPV16183133455258HPV90%HPVHPVHPV REC603 – IIIHPV REC603HPV61116183133455258REC603III36422025BLA 20187REC603INDIIII HPVIIIREC603IIIGardasil®916,050REC60336422025BLAINDREC603 REC603REC603 REC603IHPVNAb GMT HPVREC603HPVHPV REC603IREC603HPVHPV2009Merck Sharp & DohmeGardasil®986.6%REC603I53.75%1 HPVREC603 HPV HPVHPV90%90%HPVHPV HPV2016HPV201966.7%HPVHPVHPV20192019-2022HPVHPVIIIHPV 2022830HPV9452021REC603III945 HPVHPV 1 HPVIIIHPVIIIHPV 18A.08(3) REC601 – I(16/18)HPV HPVHPV HPV1618HPVREC601IIREC6019-45430HPV1618100.00%100.00% HPV1618HPV16GMT632.99HPV18GMT1,194.02REC601HPV REC602 – I(6/11)HPV REC602HPV6/11HPV2022IREC602HPV REC604aREC604cHPV HPVREC604aREC604cHPVMerckGardasilGSKCervarixAS04HPVREC604aREC604cREC604aHPVREC604cREC604c REC610III REC6102023102023LP021513.3IIIIIIIREC610401824,640REC610Shingrix®40REC610SAEAESITEAEREC610gEShingrix® 1)REC610SAEAESITEAEREC610Shingrix®TEAETEAETEAETEAE121-3REC610≥5%TEAE 2)REC610gE30Shingrix®Shingrix®REC610REC610Shingrix®60230gEgEGMTGMISCRREC610GMTGMIREC610Shingrix®60230ICS12gECD4+TCMIREC610Shingrix® (VZV)REC610BFA01VZVE(gE)CD4+T40407Shingrix® REC625 REC625REC625B2025 ReCOV ReCOVBFA0320214ReCOV2023mRNAmRNA GMP(QP)REC610REC625 REC609 REC609 REC629 HPVREC629 REC630 HPVREC630 REC608 REC608 REC617 REC617 21AS01AS03 AS04 CpG1018MF59FDA20FDABFA01BFA03CEPI CHOHPV 2004ELISPOTICS 20100IPD IPDIPDIPDIPD IPDIPMT 20241231476.1 IND4,0003,800HPV HPV2,000HPVGMP(QP)REC610REC625 HPV2024HPVREC603REC603 33731042HPV(HSV)SARS-COV-2(RSV)4030520241231 2024123153120241231187.920231231227.6 •••• •HPV•••BD• 20231231100.638.8%2024123161.6(i)24.2(ii)8.5 202312318.569.4%202412312.6 20231231487.82.4%20241231476.1 •20231231197.543.020241231154.5REC603III3642 •IND2023123120.15.22024123114.9 •2023123150.022.42024123172.4HPV284.1 20231231143.824.1%20241231109.1 2023123119.32024123116.98.73.1 2023123113.62024123118.9 (i)(ii)(iii)(iv)(v)(vi)20231231840.825.5%202412311,054.8HPV (i)50HPV(ii)2023123143.420.3%2024123134.6 20231231122.221.9%20241231149.0 20231231123.220241231136.3(i)2022H13.4(ii)55.3(iii)23.1 20231231912.450.0%20241231456.5 20231231115.148.0%2024123159.8 20231231268.10.5%20241231269.4 2023123119.243.8%2024123110.8 20241231456.520241231456.5271.259.4%182.540.0%2.80.6% 20231231685.1126.9%20241231-184.3(i)515.9(ii)453.12024123120020264114620251231 20241231169.22023123183.5 20241231878.3499.420253.15%6.70%378.9202620283.15%6.70% 202312312.5202412310.78 2024123172.7%2023123151.0% 20241231 (i)(ii)(iii)(iv)(v)(vi)20231231212.020241231171.8 2023123176.220241231381.8 20241231 2025327200202641 14620251231 2024123150202412312,739,00020232,063,000 20241231 20241231 20241111143,112,70220241111143,112,7025.591.0020241224 800,000,004 (i)70%5.631%31%8% (ii)30%2.4 20241111H8.24 202411112024122420251920252272024125 C.2.1 (i)(ii)(iii) 2022331H2022423669,7142023320202332020241231662,5957,119 20241231 2024320(i)(ii)2025 202412312023 20241231202412312024123120241231 H 20256172025620HH2025620H2025616H183171712-1716 (www.hkexnews.hk)(www.recbio.cn)20241231HH 2025328 422007720116201362015720157201732017320193201936609 20072013 2025328 GAO Feng