第19版，《世界卫生组织卫生紧急情况方案流行病学公报》，世界卫生组织东南亚区域办事处，2025年9月24日。报告期：2025年9月7日至22日

WHO Regional Office for South-East Asia19thedition(2025),24September2025Reportingperiod:07Septo22Sep2025 Thisepidemiological bulletin aims to providethe situation of key infectiousdiseases intheWHOSouth-East AsiaRegionto inform risk assessmentsand responses. The bulletin usesinformation from publicly availablesources andwill be published every two weeks.Forfeedback or suggestions, please writetoseoutbreak@who.int. Key events and updates................................................................................................................................2India: Amoebic Meningoencephalitis..............................................................................................................2Nepal: Cholera..............................................................................................................................................3Update: Amended International Health Regulations enter into force..............................................................4Influenza........................................................................................................................................................5Situation in theWHO South-East Asia Region.................................................................................................5COVID-19.......................................................................................................................................................7Situation in theWHO South-East Asia Region.................................................................................................7SARS-CoV-2 variants in the South-East Asia Region.........................................................................................9Mpox............................................................................................................................................................10Situation in the WHO South-East Asia Region...............................................................................................10Dengue.........................................................................................................................................................12Situation in theWHO South-East Asia Region...............................................................................................12Bangladesh.................................................................................................................................................13India...........................................................................................................................................................14Maldives....................................................................................................................................................15Nepal.........................................................................................................................................................15Sri Lanka....................................................................................................................................................16Thailand.....................................................................................................................................................17Annex...........................................................................................................................................................18WHO resources on mpox.............................................................................................................................18 Key eventsand updates India:Amoebic Meningoencephalitis Situation overviewas of 23 September 2025 According to the official Integrated Disease Surveillance Programme (IDSP) reportof Kerala State, India1:•As of 22 September 2025, 77laboratory-confirmed cases ofamoebic meningoencephalitis and 21relateddeaths have been reported this year.oOf these,30casesand11 deaths were reported in September2025. Nepal:Cholera Situationoverviewas of24September2025 •On 22 August, health facilities in Birgunj Metropolitan City reported a sudden increase in Acute Watery Diarrhea(AWD) cases2.•According to the Public Health Emergency Operations Center(PHEOC)of Madhesh Province:3oTotalof1543casesofAWDwere reported between 9Augustand23SeptemberoOut of1543cases:➢1328suspected cases➢32 culture positive➢183RDT positiveoAs of 23September:➢31casesremain active, while 1,512caseshave recovered.➢The 15–24 years age group was mostaffected, with 360cases (23.3%), while 112cases (7.3%) werereported among children under 5 years.➢Most cholera cases were reported in wards 11, 12, and 13, which are densely populated areas.➢No cholera deaths were reported. Figure2.The daily number of AWD cases reported in Birgunj Metropolitan City, Parsa district, Madheshprovincefrom 9 August to23September20254 Public health response3 •Approximately13000 households in Birgunj havebeenreachedwithriskcommunication,so