流行病学公报世界卫生组织卫生紧急情况方案世界卫生组织东南亚区域办事处第11版（2025年），2025年6月4日报告期：2025年5月19日至6月2日

WHO Regional Office for South-East Asia11thedition(2025),04 Jun2025Reportingperiod:19Mayto02 Jun2025 Thisepidemiological bulletin aims to providethe situation of key infectiousdiseases intheWHOSouth-East AsiaRegionto inform risk assessmentsand responses. The bulletin usesinformation from publicly availablesources andwill be published every two weeks.Forfeedback or suggestions, please writetoseoutbreak@who.int. Bangladesh: Avian influenza A(H5N1).......................................................................................................................2World Health Assembly adoptshistoric Pandemic Agreement.................................................................................2Extension of the standing recommendations for COVID-19.....................................................................................3 Situation in WHO South-East Asia Region.............................................................................................................4SARS-CoV-2 variants in the South-East Asia Region..............................................................................................5 Influenza............................................................................................................................................8 WHO resources on mpox........................................................................................................................................16 Key eventsand updates Bangladesh: Avian influenza A(H5N1) Situation overview as of27 May 202512 •An avian influenzaA(H5N1)humaninfectionclade 2.3.2.1a was detected in April 2025 in Khulna Division.•Genetic sequence data (EPI_ISL_19875512) was submitted to GISAID on 18 May 2025.•Of note, in March 2025, an avian influenza A(H5N1) outbreak was reported in poultry in Jessore, the samedistrict where the case was found.•A secondavianinfluenza A(H5N1)human infectionclade 2.3.2.1awas retrospectively detected from a samplecollected in February 2025in Khulna Division.•Genetic sequence data (EPI_ISL_19882255) for this case was submitted to GISAID on 26 May 2025.•Both cases have recovered.These mark the 9thand 10thA(H5N1) cases since the first case was detected in 2008. World Health Assembly adopts historic Pandemic Agreement3 •On 20 May 2025,Member States of the World HealthOrganization (WHO) formally adopted by consensus theworld's first Pandemic Agreement.•The landmark decision by the 78th World Health Assembly culminates more than three years of intensivenegotiations launched by governments in response to the devastating impacts of the COVID-19pandemic anddriven by the goal of making the world safer from–and more equitable in response to–future pandemics.•The WHO Pandemic Agreement sets out the principles, approaches and tools for better internationalcoordination across a range of areas, in order to strengthen the global health architecture for pandemicprevention, preparedness and response. This includes through the equitable and timely access to vaccines,therapeutics and diagnostics.•The Agreementrespects national sovereignty,while itcalls for mechanisms like the Pathogen Access andBenefit Sharing (PABS) system and the Global Supply Chain and Logistics Network (GSCL).•Negotiations on the PABS annex and the financial and logistics mechanisms are to continue under anIntergovernmental Working Group, with the annex expected to be considered at the next World HealthAssembly.It will enter into force once ratified by 60 countries. Extension of the standing recommendations for COVID-194 •The standing recommendationsfor COVID-19are issued by theWHODirector-General of the World HealthOrganization (WHO)on 9 August 2023in accordance with provisions of Articles 16 to 18 and 50 to 53 of theInternational Health Regulations (2005).On30 April 2025, thesestanding recommendationswerefurtherextended by the Director-General.•The extension of these standing recommendations is necessary to support States Parties in addressing the risk posed by COVID-19 and to prevent or reduce theinternational spread of COVID-19, as well as its impact onhealth.•These standing recommendationsare in effect for all States Parties until 30 April 2026.•Please find the full scope of the standingrecommendations atthe followinglink. COVID-19 Situation in WHO South-East Asia Region As of1 June2025 •Some countries in the Region, such asBangladesh,India, Myanmar andThailand, are showing a rapid increaseof COVID-19 cases in the recent weeks(Figure1).•In week22,(26Mayto 1 June 2025),Bangladesh reported a total of 47 cases5,India reported a total of3 961cases and20deaths6,whileMyanmar reported a total of 17 cases7.Thailand reported a total of53614casesand five deathsas of week 218.•The Region has recorded a cumulative total of 61520020COVID-19 cases, including 808945deaths.•Globally,777825189COVID-19 cases, including7095903deaths have been cumulatively reported, as of11May9.Please visit theWHO COVID-19 dashboardfor the global