北海康成-B2024 年报

CANbridge Pharmaceuticals Inc.北 海 康 成 製 藥 有 限 公 司 Incorporated in the Cayman Islands with limited liability 年報2024 2681012253170889394969799 A FDA 20211210 2022624 20211118 20211118 2019201972520192021611 0.00001 % 89 Nexus WayCamana BayGrand CaymanKY1-9009Cayman Islands Fangxin Li20249302024922024930 Ogier Global (Cayman) Limited89 Nexus WayCamana BayGrand CaymanKY1-9009Cayman Islands Richard James GregoryJames Arthur Geraghty 183171712-1716 38821618 120B01 11 1228 1131 James Arthur GeraghtyRichard James Gregory Richard James GregoryFangxin Li www. canbridgepharma.com Richard James GregoryJames Arthur Geraghty •20231231102.917.817.3%2024123185.12021®2023®20235.86.4% •20231231257.25.42.1%202412 31251.8CAN103 •20231231378.863.816.8%20241231442.6202488.0202324.26.4% •20231231358.912.03.3%20241231346.9442.62023378.8 2024 CAN103 672025350 2024(ALGS)(PFIC)CAN103NDACAN103 20251172025C 201220241231822 20241231672025350(CHARD) 2012 MPS II(LSD)AALGSPFIC •20209®(CAN101)II •2023®ALGS•2024®ALGSPFIC®ALGS•20236PNHCAN106 1bLDH •202411GDCAN103202532025CAN103 202411ScriptrStitchR™ RNA 202013203025934.5% 2018121202386207 20251 17202549 80% 我们的组合包括具有有效作用机制的生物制剂、小分子及基因疗法解决方案，针对拥有巨大市场潜力的部分最常见的罕见病适应症。在8项药物资产中，北海康成拥有其中5项的全球权益。 20211210 ®CAN101 •®MPS IIERTERT® •20209®MPS II®GCPharma10I/IIElaprase®®MPS IIIII® •20215®20241231843202412311075.21 • ®CAN108 •®IBATALGSFDAPFIC®1,700®ALGSPFIC200Mirum Pharmaceuticals, Inc.MirumALGSIIb118®Mirum®PFICIII93PFIC1PFIC2PFIC3 PFIC4 PFIC6PFICIII®z ® •20241231®ALGSPFIC®ALGS •20245®ALGS ®PFIC •202412®ALGS •20241®2024123183920241231351.61 •PFIC®PFIC®ALGS CAN106 •CAN106C5PNHMGCAN106PK/PDCAN106PNHC5 •20192020WuXi Biologics Ireland LimitedPrivus Biologics, LLCPNHC5CAN106 •CAN106FDAMGCAN10650%MG7 •20236CAN106PNH1bCAN10624C53C50.5CAN106CAN106PNH •C5CAN106PNH CAN103 •CAN103GDERT •CAN103ERT •GD IIIICAN103 I/IIGDGD III2269.HKCAN103ERTIIIIGD •20248CAN103 •202411GDCAN1032025CAN103 •202411ScriptrStitchR™ RNA GC PharmaMirumCDMO (KOL) 20252 2420252282025225 202412 3199,703,000 20231231102.917.82024123185.12021®2023®20235.86.4%2024® 2023123138.77.92024123130.8 2023123164.29.92024123154.32024123163.8%2023123162.4% 2023123112.74.8202412317.9 2023123183.78.82024123174.9 2023123189.821.72024123168.2 20231231257.25.420241231251.8CAN103 202312318.9202412318.6 2024123187,987,000 2024123110.54.81.10.094.5202312 31137.5 20241231CAN008GBM202456 2024123130.4202312 3130.33.35%4.0% 202412 319.4%2023 12 3164.0%20241231 202312317.7% 20241231 2024123120241231105,000 202412 31469,00020241231 20241231 2021611 54,549,23055,708,000 276,2009,178,0722024123129,532,583 202111182024627 202462710%10% 6,336,000 20241231534,3753,619,625202412316,794,750 202111182024627 202462710%10% 12,815,000 202412317,230,8902024123115,206,171 55201812021621 25Kosan Biosciences, Inc.19985200082002(Genzyme Corporation)201120126Tullis Health Investors 2016520178Termeer 19927199741998420025 Fangxin Li32202493020214Li6032592359WuXi AppTec Singapore Pte. Ltd.Li255220194202012Bain & Company2016820191HAIKUI Regenerative Medicine Li2014620189 James Arthur Geraghty702018718Geraghty Geraghty3320135201612GeraghtyThirdRock VenturesGeraghty20114201212SanofiS.A.Geraghty1992201119932007GeraghtyGenzyme Transgenics CorporationGeraghtyGeraghty2018520241201711202412Orchard TherapeuticsORTXPieris PharmaceuticalsPIRSGeraghty201610201412013720233Fulcrum TherapeuticsFULCVoyager TherapeuticsVYGRAceragen, Inc.ACGNIdera PharmaceuticalsIDRA Geraghty19805 Richard James Gregory6720204Gregory Gregory33GregoryHomology MedicinesFIXXProMIS NeurosciencesPMN202362015120198GregoryImmunoGen Inc.19892GregoryGENZ25Genzyme Sanofi1990Canji, Inc.1989Gregory(WorcesterFoundation for Experimental Biology) Gregory1980619861Gregory20102(American Institute forMedical and Biological Engineering) 612021611 28201922024111902202162279202112561202482126 2017102019509072012120179 20111201111CIG20067201112005320066200082004122009121401994520008BNP Prime Peregrine Capital Limited 1989519981119921119937 562022216 222002820043JP Morgan Chase Bank2004620131213 199320002002 432020122021621202492 202136996202012CNTB2020102023126881762020220216Abbisko Cayman Limited20162Qiming Venture Partners20149201612012112014860027620099201210 2004720091 632022752024930 6032592359201882020520163201912017320078201512WuXiPharmaTech (Cayman) Inc. 20001020077Tanox Inc.TNOX20078Genentech Inc.19984200010Biogen Inc.BIIB19965199812 202172616201422021622692022720232AMAN20243Johnson & Johnson2018520213Viela Bio Inc.VIE 198371993519965(Carnegie Mellon University) 55201812021621Glenn Hassan20249 Gerald Cox6620197 20162018CoxCambridgeEditas Medicine20082016CoxCambridgeCerdelga®Xenpozyme®Hectoral®Cerezyme®Aldurazyme®Elaprase®Cox Cox1989199719801989 2024123139202412316 202412 31202412 31 93 20241231(2023 202112108 14 26 9638 20241231 20241231 2021121056,251,00012.182021129 20211210604.0 2024123