北海康成-B：截至2025年6月30日止六个月中期业绩公告

CANbridge Pharmaceuticals Inc. 1228 2025630 20256 302024630 20258301015(i)®®®50(ii)74,971,46814.99%100 ®CAN101II(MPS II(ERT)MPS II2018 573 •20215®202563086720256301305.61 ®CAN108(ALGS)(PFIC)(IBAT)®ALGS202395 •20241®2025630874ALGS2025630391.96 •20245®ALGS ®CAN103(GD)ERTGD 2018 531 •20253GMP III1 •20255I (AAV)(DMD2018598 •2025630ScriptR GlobalStitchRDMDStitchRAAVsDMD20256 30DMD 20258122025 2025 202520252025 •202463044.822.550.3%202563022.220212024®®®20241.76.9%2025® •20246 303.6100.52025630104.1101.02025224202522820241231202563097.73.3 •2024630173.3155.389.6%202563018.02025 •202463035.719.053.4%202563016.6 •20246 3039.817.143.0%202563022.720242025® •306.52024630247.3202563059.259.2 •2024630216.2178.982.7%202563037.459.22024630247.3 2025630 63020252024 59,238(247,269) 1,783(11,465) 61,662(245,244) 90.14(0.58) 20256 30 202563020241231 1699525612,68761,29367,822 62,02371,461 43,47945,352 506,160482,610 (400,658)(365,797) 8,00015,04242293,649 8,422108,691 (409,080)(474,488) 122828(409,108)(474,516) (409,080)(474,488) 2025630 1. 201813089 Nexus Way,Camana Bay, Grand Cayman, KY1-9009, Cayman Islands 20211210 2. 202563034202412 31 2025630462,681,000409,080,00020256301,960,0001224,173,0002025630 1.20258 11®®®502025827 2.202581274,971,4681.34202582798,661,0002025827 3.20256 30CAN203CAN201CAN202 CAN107 4.202532020253 5.20256 30 6. 7. 8.® 9.2025515IIII 202563012202563012 1. 2. 3. 4. 5. 6. 3. 20241231 202511 21 4. 2025202463010% 22,24844,794 3090 3701,248 103,7752,350 104,1453,598 6. 7. 16.5%202416.5%2,000,0008.25%16.5% 20%202420% 25%202425% 21%202421% 10%20081 120071231 8. 20256302024 9. 424,838,3202024424,378,752 20252024630 63020252024 7,16816,723 202563020241231 202563020241231 7,16816,723 11. 20256302024123178,384108,294314,566262,164392,950370,458 66 12. 202563020241231 5,000,000,0000.00001202412 315,000,000,000 424,838,3200.00001202412 31424,838,320 20122025630731 202563045(CHARD) 2012 MPS II(LSD)AALGS(PFIC) •20209®(CAN101)MPS II ®ALGS •2024®ALGSPFIC®ALGS •20236PNHCAN106 1bLDH III1 202411ScriptrStitchR™ RNA 202013203025934.5% 2018121202386207 20251 1720252025420259 80% 20258(i)®®®50(ii)74,971,46814.99%100 2025 202520252025 20211210 ®CAN101 •®MPS IIERTERT® •20209®MPS II®GC Pharma101/2Elaprase®®MPS IIIII® •20215®202563086720256301305.61 ®CAN108 •®IBATALGSFDAPFIC®1,700®ALGSPFIC200Mirum Pharmaceuticals, Inc.MirumALGS2b118®Mirum®PFIC393PFIC1PFIC2PFIC3 PFIC4 PFIC6PFIC3®z •Mirum® •20241231®ALGSPFIC®ALGS •20245® •202412®PFIC •202412®ALGS •20241®2025630874ALGS2025630391.96 ®CAN103 •GDERT •ERT •20231GD IIII1/2GDGD III2269.HKERTIIIIGD •20253GMP •20255IIII1 CAN106 •CAN106C5PNHMGCAN106PK/PDCAN106PNHC5 •20192020WuXi Biologics Ireland LimitedPrivus Biologics, LLCPNHC5CAN106 •CAN106FDAMGCAN10650%MG7 •20236CAN106PNH1bCAN10624C53C50.5CAN106CAN106PNH •C5CAN106PNH •202411ScriptrStitchR™ RNA 20253GMP GC PharmaMirumCDMO 20258®®® (KOL) (1)2025811®®®5020258 27 (2)20258 1274,971,4681.34 202582798,661,000(i)(ii)(iii)(iv) 8122025827 (3)20258 272025827 202463044.822.5202563022.220212024®®®20241.76.9%2025® 202463015.48.520256306.8 202463029.414.0202563015.4202563069.3%202463065.7% 20246303.6100.52025630104.1101.020252242025228202412 31202563097.73.3 202463039.817.1202563022.720242025® 202463035.719.020256 3016.6 2024630173.3155.320256 3018.02025 202463027.020256301.3202463026.32025703,000 20246304.620256301.8 (1)2 (2) (3) 20256302.01.00.55,0000.52024123110.5 2025630 202563032.2202412 3130.420256303.35%6.00% 20256308.6%202412 319.4%2024630 202563030.5%2024123126.0% 2025630 20256302025630145,000 20256 30491,0002025630 2025630 201972520192021611 54,549,23055,708,000 6,244,823202563023,287,760 202111182024627 20246 27202462710%10%2024627 42,483,832202563010% 581,4001,301,60020256 304,911,750 202111182024627 20246 2720246 2710%10%2024627 42,483,832202563010% 4,602,421202563010,603,750 C1 C.2.1 2012620181 C3 2025630 202563045202412 3167 27.7202463054.1 6302024630 James Arthur GeraghtyRichard James Gregory 20256302025630 202563024102410 34 22025630462,681,000409,080,00020256301,960,0001224,173,0002 22 (www.canbridgepharma.com)(www.hkexnews.hk) 9 2025831 Richard James GregoryJames Arthur Geraghty