北海康成-B2023 年报

CANbridge Pharmaceuticals Inc.北 海 康 成 製 藥 有 限 公 司 Incorporated in the Cayman Islands with limited liability 26810122733729095969799100102 A FDA 20211210 2022624 20211118 20211118 2019201972520192021611 20211130 0.00001 89 Nexus WayCamana BayGrand CaymanKY1-9009Cayman Islands Derek Paul Di Rocco20231123 Ogier Global (Cayman) Limited89 Nexus WayCamana BayGrand CaymanKY1-9009Cayman Islands Richard James GregoryJames Arthur Geraghty 183171712-1716 38821618 120B01 11 1228 97927 James Arthur Geraghty www. canbridgepharma.com Richard James Gregory Richard James GregoryJames Arthur GeraghtyDerek Paul Di Rocco20231123 2022123179.023.930.3%20231231102.9®® 20221231311.254.017.4%20231231257.2 •20221231483.5104.721.7%20231231378.8 •20221231456.797.821.4%20231231358.9378.82022483.5–– 2023100 2023–® 202330.3%102.9®® ®CAN10820235ALGS2023910®ALGS® ®20215®2023123175720231035 CAN106CAN106C5PNH20236CAN106PNH1bCAN106C5(LDH)C5CAN106PNHCAN106PNH 202420242 120243 2024328 20122023123114 202312311001370%(CHARD) 2012 MPS II(LSD)AALGSPFIC2020 9II®(CAN101)20235®ALGS2023920231020217PNHCAN106IND20222CAN106 I20236PNHCAN106 IbLDH20227CAN103 I20231II 20231231LogicBio TherapeuticsAAV sL6520231ChanSMA(CNS)AAV 198320161,09020201,3515.5%2020203011.0%3,833 202013203025934.5% 2018121202386207 80%(Novartis)SMAZolgensma®Sarepta Therapeutics Inc.(DMD)Elevidys® 20225 9127 2023921651126420182022274202345418131 2024202421 20243 ҵ஄ЋיҪԖࣩ䟖ռ俠 ⋾㵞⺞ㇷ㒨㛰柬岮䔉Ḕ柬䙫⅏䏪㫱∐Ə㶜咲䔆䉐壤≸˚⯶⇭⬷⑳⟡⛇㲢䘩˛怀Ẃ懄⯴㛧⸟奲䙫似奲䖥䖬⑳兒䘋⭟恐ㆰ䖮Ə⅞㛰䵺怵樾嬰䙫㩆∝⑳ⷩ⠛㽂⊂˛ 20211210 ®CAN101 •®MPS IIERTERT® •20209®MPS II®GCPharma10I/IIElaprase®®MPS IIIII® •20215®20231231757202312311035 • ®CAN108 •®IBATALGSFDAPFIC®1,700®ALGSPFIC200Mirum Pharmaceuticals, Inc.MirumALGSIIb118®Mirum®PFICIII93PFIC1PFIC2PFIC3 PFIC4 PFIC6PFICIII®z •Mirum® •2023®®ALGS •Mirum2021 9ALGS®FDA202212Mirum20243PFIC®FDA CAN106 •CAN106C5PNHMGCAN106PK/PDCAN106PNHC5 •20192020WuXi Biologics Ireland LimitedPrivus Biologics, LLCPNHC5CAN106 •CAN106FDAMGCAN10650%MG7 •20236CAN106PNH1bCAN10624C53C50.5CAN106CAN106PNH •C5CAN106PNH CAN008(ASUNERCEPT) •CAN008CD95-Fc(GBM)CAN008CD95LCD95CAN008CD95LCD95T •GBMFDA(EMA)EMACAN008CAN008CAN008GBMII •CAN008GBMGBMI200400CAN0084001257% (4/7)(PFS)IIApogenixGBMII50%46 •20236CAN008GBMIIII11921CAN008 400GBM(OS) •20244(CAN008 IICAN008CAN008 CAN103 •CAN103GDERT •CAN103ERT •GD IIIICAN103 I/IIGD2269.HKCAN103ERTIIIIGD •20231012GDIIIICAN103 IIIIIICAN1039CAN103 •2024 • •ChanscAAVhSMN1hSMN1SMA •ChanHorae20235ASGCTCAN203SMASMAASGCTSMAhSMN1hSMN1SMAFDASMA •20231030ESGCT30CAN201CAN201(AAV)sL65A-GALPXBCAN201-GALGb3 •ChanHoraeAAVSMA20242EMBO Molecular MedicineFDASMASMNSMASMNCAN203 GC PharmaMirumCDMO (KOL) 2022123179.023.930.3%20231231102.9®® 2022123130.18.62023123138.7 2022123148.915.32023123164.22023123162.4%202261.9% 2022123112.90.22023123112.7 2022123186.83.12023123183.7 20221231108.919.12023123189.8 20221231311.254.020231231257.2 202212316.9202312318.9 202312 31137.548.382.21.55.520221231463.1 20231231 2023123130.3202212 3137.623.76.63.35%4.00% 202312 3164.0%202212 31181.6%20231231 202212315.4% 20231231 202312312023123138.7 20231231CANbridge Biomed Limited202312 31 12.620231231 20231231 201972520192021611 54,549,23055,708,000 20231231150,2001,392,7312023123138,986,855 20211118 5%5% 20231231752,250285,000202312314,612,750 20211118 10% 202312311,318,000202312319,622,000 54201812021621 24Kosan Biosciences, Inc.19985200082002(Genzyme Corporation)201120126Tullis Health Investors 2016520178Termeer 19927199741998420025 422020122021621 202136996202012CNTB2020102023126881762020220216Abbisko Cayman Limited20162 Qiming Venture Partners20149201612012112014860027620099201210 62202275 6032592359201882020520163201912017320078201512WuXiPharmaTech (Cayman) Inc. 20001020077Tanox Inc.TNOX20078Genentech Inc.19984200010Biogen Inc.BIIB19965199812 202172616201422021622692022720232AMAN20243Johnson & Johnson2018520213Viela Bio Inc.VIE 198371993519965(Carnegie Mellon University) James Arthur Geraghty692018718Geraghty Geraghty3220135201612GeraghtyThirdRock VenturesGeraghty20114201212Sanofi S.A.Geraghty1992201119932007GeraghtyGenzyme Transgenics CorporationGeraghtyGeraghty2018520233201711Orchard TherapeuticsORTXPieris PharmaceuticalsPIRSGeraghty201610201412013720233FulcrumTherapeuticsPIRSVoyager TherapeuticsVYGRAceragen, Inc.ACGNIdera PharmaceuticalsIDRA Geraghty19805 Richard James Gregory6620204Gregory Gregory32GregoryHomology MedicinesFIXXProMIS NeurosciencesPMN202362015120198GregoryImmunoGen Inc.19892GregoryGENZ25Genzyme Sanofi1990Canji, Inc.1989Gregory(WorcesterFoundation for Experimental Biology) Gregory1980619861Gregory20102(American Institute forMedical and Biological Engineering) 602021611 27201921902202162279 2017102019509072012120179 20111201111CIG20067201112005320066200082004122009121401994520008BNP Prime Peregrine Capital Limited 1989519981119921119937 552022216 212002820043JP Morgan Chase Bank2004620131213 199320002