制药工艺与装备1：生物制药工艺与生产

ISSN16745922CN115669T LIUCHENGGONGYE1998661 02 202502 PharmaTECp 驯“菌 破解万 产业化 ”之道， 吨罐的 密码 薉椚欰蟢玐欰暟助灇瑕玐嵳 Lz 18 A 34 i n 48 g 199820Q202502661 g 3yJ22100037 g 4 4 W 861063326091 Emailprocessvogelcomcn 3861063326083 3 fl 3ISSN16745922 3CN115669T 10 jjyJ2223100037 Add3rdFloor2ndBuildingNo22BaiwanzhuangStreetXichengDistrictBeijing100037 Tel861063326090 Tel1391726425417755450823 Tel18662595387flTel13683598646Tel18810368957Tel18510064198Tel18545558115 JMMediaCorporation Tel886422965959 j VogelCommunicationsGroupGmbHCoKG Tel499314182988 GardnerBusinessMediaInc Tel15135278800 FerdinandoSalarisTel393388285021 VogelCommunicationsGroupAG Tel41447227700 WRavenMediaspzooTel48717823181AMMpublishingsroTel420775245802TechnikMedienVerlagsgesmbH Tel43187683790 MszakiMdiaKiadKftTel36203967942 GreenWorldMedidaThailandCompanyLimitedTel6627311191 MMMaschinenMarktKoreaCoLtdTel821084065100 3gPROCESSInternationalEditorialofLiuChengGongYeislicensedfromPROCESSNN jAdvertiserIndex 31 43 Sievers47 FLYGER57 20250231 ISSN16745922CN115669T LIUCHENGGONGYE1998661 02 202502 PharmaTECp 驯“菌”之道， 破解万吨罐的产业化密码 薉蟢椚欰玐欰暟助灇玐瑕嵳 Lz 18 34 48 Aig n PharmaTEC h 蚋蒌鄳 1IBSN錠B5蚋 httpspharmjgvogelcndzzz Q 20250231 202502 fi50LfiCIPP20P23 暟PWFSFJHVSF 06“”Thewaytotamethe“strain”crackingtheindustrializationcodeof10000tonbioreactor 遤錜OEVTUSZ0CTFSWBUJPO 10Nn3g Q Researchontheapplicationofsmartcontroltechnologyofsmartmechanicalequipmentinpharmaceuticalproductionprocess 13fig Q Efficiencyimprovementandcostoptimizationofpharmaceuticalcommoditysupplychainmanagementbydigitaltransformation 暵瘻欰暟蚋蒌欰BJPQIBSNBDFVUJDBM1SPDFTTBOE1SPEVDUJPO 18A Thekeypointsoffermentationsystemdesign 21ADCnfiCCS CCSinthedesignandoperationofADCformulationproductionequipment 24 Howtodoagoodjobofshowerballcoveragetesting 26nJ侹QMisconceptionsinthevalidationofcomputationalsystemsinbiopharmaceuticalPlants 29nCIPpCommonproblemsintheCIPprocessofbiopharmaceuticalpipelineandtanksystems 鄳縨玐FBDJMJUZBOEOHJOFFSJOH 32 Projectmanagementofconstructionprojectsinpharmaceuticalcompanies 34inQ Applicationofvaporizedhydrogenperoxidespacesterilizationinvaccine production 鵂玐助蒌1SPDFTT5FDIOJRVFT 39n 3 Anewformofmassproductionofinvitrodiagnosticreagentslyophilizedmicrospheretechnology 44pQ N Analysisofcommonproblemsandsolutionsinthefillingandsealingprocessof smallvolumeinjectionswithprefilledSyringes 48g Studyonthepunchingmoldoftabletpressmachine 52fiQ Doublepersuasion 543 Applicationoffluidicetechnologyinpharmaceuticalfield 暟崨鄳LPHJTUJDTBOE1BDLBHJOH 56i侹 Simulationbottleneckanalysisofpilotlineinpharmaceuticalworkshop 荈邍AVUPNBUJPOBOEOTUSVNFOUBUJPO 59侞ffingny DigitallydrivenfutureofsyntheticbiologyansmartpathfromRDtoproductionPartII 餘2VBMJUZPOUSPM 623Wg“ DeterminationofsixcomponentsofGynecologyNourishingRongPill 23202502 ISSN16745922 CN115669T LIUCHENGGONGYE1998659 202412 侞 Contents ffifigfifi nfi 。P12 30 54 nfin倅i 倅fi 7F20iP52 灇LBCPSBUPSZ3 66g 4 Coldandfluclearheatonestepgranulationpreparationprocess 7005ZnRemovalofantibacterialactivityof05levofloxacineyedropsbymicrobialcountingmethod 74Jng Studyonmicrobiologicalexaminationmethodsofciprofloxacinlactateandits preparations 度BVZFSTVJEF 78ffiBusinessNews 79Products 1AImprint 1AdvertisementIndex ISSN16745922CN115669T LIUCHENGGONGYE1998661 02 202502 PharmaTECp 驯“菌”之道， 破解万吨罐的产业化密码 薉蟢椚欰玐欰暟助灇玐瑕嵳 Lz 183448 Aig n 3 fi Cz3gr“”P06 嬞斁 丷 斁孷 蚋用乄 1IBSNB5蚋 12 PharmaTEC k k 16 J 20250233 Q HIGHLIGHTSDIGITAL 2025J fi 哦Q CCSfi Vfi 3fi PharmaTECgBioValley33031Q2025fiJ””flJ Afi J gj QA OEB45 Ffi DJ9 JQfifi fifi3 Vfi 2025哦N fifiF3 3fig3fi3fi fi2025” 43202502 下ffi 丿 呒価g乶橐檳 z劥勝揍勫CN115669T揍勫ISSN16745922R协JR勲愳御D於嵲 汯Dg乶徰従徰n掿棭汯揊R勍湵搎Dg孾Q 揊尻滂斾Q。 忌摯尻XX员D徸滂Q 丿 徰卭 嵲 尻、 员X汯nQgg佖佉。仠櫭嵲相R巕n哸3各0巕尻RQg慺 佖 员勽噬搏ff斾価哸岴埅哸徰従揊搏掶樠徰掿揊勽噬ff佉沁。 掶 X汯n揊g乶佉。仠相揊IR狶n 嗤Q 嵲X汯嗤RQ徰nQg於nfi。 搉徰 嵲X汯ng徰nQgR価。仠徚徰nI哸嵲佉勄J忺。 J岴卭 嵲X汯J岴卭n徰従徰搏掿尻R価佉歎n。仠相哸3各巕槜沁nR懜。 EHS価 嵲X汯EnvironmentHealthRSafety価ng乶R揊g。仠湵g乶櫭嵲忘歌n勑徬n。 斾価 嵲X汯斾価斾斾価相R。仠櫭嵲相n斾価g斾価歎。 ffX岴 嵲X汯嗤SffX価哸ffX哸岴佉沁。 湵gQ 员X汯nDg揊g嗤滂g橐湵徬歎ng乶R 丿0 忩徱槜httpsmanuscFiptjgcmaccnFoleauthoF 3匔捾擗 忏01063326090捙501各13699188243 0M22100037 j XnngLH “” g“”3 A 3 QWjg3g3“” 3 3 Cg “”NQ Q3 g 5033N1980 3“” A j “80 ”2015 3 3g gfi 1970“”3 “” g 21a“ ” QM fi CART“gj3 fi5” Q3 Q a “3”Q“90 C ” fi 1980B 3QQ a Q3 150L500LQfi 3g 3 “”“ g 500t3 ” Qg A “CART ‘3’” 2fi “ g” “” gA“3” “f” 3 ja“” “” “ 3 33g2g “”33 Cg3 g a3 a 33 g 3OUR g 3a 3g33 33 50L3500t 10L31000L33 3T n 3”“3CER 3” 3ATP3g a a CT 3 3 Q3 3 Ta g “”370m33gg23gg 35h15 3a10 33g g ggag3“g ”3 DNA g 13gL 70g i AIgg gAIgg g 3035g 2053g g305g 83000t55g3g53 36000 a ga 3g QQagg3a3 AT 2 gT a3g 3Tfi Nn3 g 1q2 12 n3n n。Jn3Jg。Xn 。tJnA。gQiJnJi3Jg Qn。EniQ。 nn n 1 g 3 g j3 21Q T 3 3 3a 3C MESERPLIMSgg33 jga a 2Nfin3 21 3 j3 T Tjg gj1 1 a a gaa 3A gaMES ERP g LIMSgg aGMP N3 g3 35g 3 3 3 3 5g g3 fia2 pH3 jNA gTg Tg 2 223 3B 3a g a a a a a aGMP g 32 33g3 3agg g3 xU A B 1 yV 3n 31 T 3 j gjgajgaa Ta g j3Aj5g a 3ga3 g3 33apH3 gTg MESERPLIMSQM