维亚生物2024年中期报告

����中期報告 2 4 19 43 45 Chartered Governance Institute 97927 榮 榮 榮 PO Box 309Ugland HouseGrand Cayman, KY1-1104Cayman Islands Chartered Governance Institute 735 33191901 Maples Fund Services (Cayman) LimitedPO Box 1093, Boundary HallCricket SquareGrand Cayman, KY1-1102Cayman Islands 1617 1873 www.vivabiotech.com CROCROCROCDMO 2,3501,142.2981.814.0%406.0339.116.5%144.213.7146.1168.215.1% CRO CRO441.3385.912.5%198.0167.215.5%EFSCROCRO 74,1099,0742,06579BDBDVBICRO SBDDNew targetNovel MOANew ModalityAISBDDCRO1,46525.7%CRO88.8%10.2%11.2%27.6% 87313 CDMOCMC CDMOCMC 595.915.0%179.016.8%CDMO 88563.2%100%12CROCMCCDMO860400 CMCCMC218CMC117CMC21.0CMCBDCMCCMCBD75.0%25.0%CMCBD49.0%51.0%CMCBD Focus-X, Saverna, Dogma, Riparian144.11Nerio9267.0%26.0% 5117.022218537133 DogmaArthrosi BaskingTriumviraDeka Mediar CybrexaHayaNerio SBDDStructure-based Drug DiscoverySBDD(AI)SBDDNew targetNovel MOANew ModalityAISBDD 2,06579PDBmRNA CROBioassayPCC GPCRIonChannel ProteinTransport Protein Cryo-EM Single Particle Analysis, SPAXX-ray crystallography XRDNuclear Magnetic Resonance,NMR V-DELDNADNAGPCRASMS, SPRIntactbioassayASMSSPRHDX-MSX XDCXDCXDCXDCXDCDNA(DEL)DEL(AOC)XDC PDCRDCAPCV-DEL PROTACCRO10.87%PROTACBioassayCADD/AIDDE350PROTAC140PROTACCRO AISBDDComputer-aided Drug Discovery, CADDArtificial Intelligence Drug Discovery, AIDDADME/PKRNACADDAIDD AISBDDCRO 2,043CRO1,117704 •40,000•7,5765,552•64,56412,21010,800•7,5455,305•6,3625,335•(CADD)(AIDD)•35,1682,5001,3001,500 (SBDD)CROCDMO 981.81,142.214.0%CDMO 642.7736.212.7% 339.1406.016.5%34.5%35.5% 44.345.11.8% 57.672.420.4% 117.2131.410.8% 42.876.744.2% EFS5% 64.414.2 4.70.6 8.759.585.4% 31.488.064.3% 41.323.178.8% 144.213.7 168.2146.1 (i)(ii) 1,035.81,036.30.05%360.3144.1 1,930.11,035.81,167.1650.1 47.1%50.5%1,151.5359.71,532.0380.5 204.2193.10.444.2 82.760.3 5% 10.140.0 3,665,141 Tricor TrustHong Kong Limited5,600,000 7,320,0007,320,000 C1 C.2.1 C3 (www.hkexnews.hk)(www.vivabiotech.com) 榮 241034 13.51B(1) 榮MakeMyTrip LimitedMMYT6686 13.51B(1) 13.2013.2113.22 XV(a)XV78(b)352(c) (i) (1)L(2)Min Zhou 2018 Family TrustMZFT, LLCMZFT, LLCMin Zhou 2018 Family TrustCCMFT Trust SchemeThe Chen Mao CharitableRemainder TrustZhou MinZhou Min維 亞 生 物 科 技 控 股 集 團(3)維 亞 生 物 科 技 控 股 集 團(4)維 亞 生 物 科 技 控 股 集 團(5)HLC VGC Partners HK II LimitedHLC SPV85,000,000HLC SPVVGC Fund IV L.P.HLC VGC GP IV Limited+ (ii) (1)(2)Chencheney Ltd.100.0%Chencheney Ltd.Anji PharmaceuticalsClues Therapeutics(3)Chencehney LtdClues Therapeutics Inc.447,039.0928%(4)(5)(6)5 XVXV78352 3365% (2)Zhou Min(3)FengheHarvest Ltd(3)Tamasek HoldingsPrivateLimited(4) 1.LS2.131,057,6543.Fenghe Harvest LtdWu and Sons Limited100.00%Fenghe CanaryLimited45.00%Fenghe Harvest LtdWu and Sons LimitedFenghe CanaryLimited4.Huangshan Investments Pte. Ltd.True Light Investments H Pte. Ltd.Tamasek HoldingsPrivateLimited150,000,000+ 336 1. (a) (i)270,937,30257,892,3512,194,55522.07% (ii) (iii) (iv)(i)422(ii)(a)(b) (v) (vi)(i)(a)10%110%(b)100%(ii)85%(iii) (vii) (viii) (ix) (1)40%20%20%20% 2. 1 i.0.1% ii.5 (i)(ii)(iii) i. ii. iii. 10%150,000,000 10% 30%30% 121% 121% (1)(i)40%(ii)30%(iii)30% 60%90%120% (2)(i)60%(ii)40% 270%360% (3)(i)60%(ii)40% 90% 111,235,000111,405,00026,640,0001.23% 0% D. 3. (a) (b) (c) (d) (i)(ii) (e) 1 (f) (a) (b) (g) (h) 20,000,0000.93%12,800,0007,200,00018,240,0001,760,000 (1)(i)40%(ii)30%(iii)30% 60%90%120%4.90 (2)(i)60%(ii)40% 270%360%5.46 (3)(i)40%(ii)30%(iii)30% 60%90%120%5.46 (4)(i)15%(ii)35%(iii)50%0.63 (5) (6) 4. 3.28% 1.446,018,3902.4.224.35100%80%3.4.224.3921025931940090% Ernst & Young27/F, One Taikoo Place979 King’s RoadQuarry Bay, Hong Kong 致維 亞 生 物 科 技 控 股 集 團 4587維 亞 生 物 科 技 控 股 集 團343434 2410 34 *30,016,00073.46%72.91% 1. 1.1 維 亞 生 物 科 技 控 股 集 團PO Box 309, Ugland House, Grand Cayman, KYI-1104, Cayman Islands33191901 ••• 1.2 34 2. 161177 (a)1616 (b)12 2. (c)77 3. (i)(ii)CDMOCDMO 4. (a) 4. 4. (a) 4. (b) 243,659,000CDMO268,410,000 5. 6. 7. 8. 16.5%16.5%2,000,0002,000,0008.25%16.5% 8. 25% 15% 15%15% 15% 15% [2023]1210025%20% 8. [2022]1310030025%20% 25% 21%8.84% 19% 9. 2,141,766,0001,915,437,000 9. 10. 11. 82,654,00053,902,000 366,000289,000241,00019,000 85,00017 12 (a) 14. 16. (a)20,000,000150,000,000(b)20%100%(c)204,639,000210,172,000193,074,000196,026,000 17. 5 18. 19. (1) 19. 20. 21. 21. 21. 22.