和铂医药-B中期报告2024

中 報2024 24572337383941424470 P.O. Box 472, Harbour Place, 2nd Floor103 South Church Street, George TownGrand Cayman KY1-1106Cayman Islands Robert Irwin KamenAlbert R. Collinson 218A3202 Albert R. Collinson 3485 International Corporation Services Ltd.P.O. Box 472, Harbour Place, 2nd Floor103 South Church Street, George TownGrand Cayman KY1-1106, Cayman Islands Albert R. Collinson 1617 Robert Irwin Kamen 97927 201623 www.harbourbiomed.com 02142 HARBOUR THERAPEUTICS 1.(HBM9161)gMGBLANMPA 2.(HBM4003)PD-1CRC 3.HBM9378 I 4.HBM9027 a.FDAINDIb.NMPAINDI 1. a.SeagenInc.HBM9033HarbourMice®MSLNADCSeagen Inc.Ib.1910575 2. a.Boostimmune, Inc.BoostimmuneADCBoostimmuneb.Alaya.BioCAR-Tc. HarbourTherapeuticsIdeaIND HARBOUR THERAPEUTICS HarbourTherapeutics HarbourMice®(H2L2)(HCAb)HCAb(HBICE®)B I to ITM IdeaINDHarbourMice®B HarbourTherapeutics 10 HarbourTherapeutics (HBM9161) FcRnFcRnIgGIgGFcRn gMGIIIIIIgMGgMG (HBM9161)gMGBLANMPANMPABLA BLA (HBM9161)gMGBLANMPA •HBM9161 (HBM4003) HBM4003CTLA-4T4(CTLA-4)THCAbHBM4003CTLA-4CTLA-4CTLA-4HBM4003T(ADCC)TregHBM4003HBM4003CTLA-4 HBM4003PD-1 PD-1 HBM7008 HBM7008(TAA)B7H44-1BBTAATTHBM7008HBICE®PD-L1PD1/PD-L14-1BB Cullinan Therapeutics, Inc.Cullinan Oncology, Inc.CullinanCullinanCullinanB7H4x4-1BB(HBM7008) CullinanCullinanCullinanHBM7008 HBM1020 HBM1020Harbour Mice®B7H7B7B7H7PD-L1PD-L1HBM1020B7H7HBM1020PD-L1PD-(L)1 IHBM1020 HBM9378 H B M9378H2L2TSLPTSLPTSLPDCT helper 2 (Th2)HBM9378HBM9378 HBM9378 HBM9378NMPAINDIHBM9378I I ICOPDIND HBM1022(CCR8)HBM9014LIFRHBICE®HBM7020(BCMAxCD3)HBM9027(PD-L1xCD40)HBM7004(B7H4xCD3)HarbourMice®HBM9033MSLNADCADC/RDC 2 IND 1.HBM1022 HBM1022G(GPCR)CCR8CCR8TTHBM1022CCR8 CCR8TregG(GPCR)GPCRCCR8TregTCCR8Treg HBM1022CCR8GPCRHBM1022CCR8T HBM1022FDAINDI 2.HBM9014 H B M 9 0 1 4L I F RHarbourMice®HBM9014LIFRIL6IL6 HBM9014HBM9014 3.HBM9027 HBM9027PD-L1×CD40HBICE®HarbourMice®PD-L1×CD40PD-L1×CD40HBICE®DCHBICE® FDAINDINMPAINDI 4.HBM7020 H B M7020H B I C E®H a r b o u rM i c e®BCMAxCD3HBM7020CD3BCMATTBCMACD3CRSHBM7020 HBM7020NMPAINDI IND 5.HBM7004 HBM7004B7H4xCD3HBICE®HarbourMice®H2L2HCAbB7H4xCD3HBICE®HBICE® HBM7004B7H4THBM7004HBM7004B7H4x4-1BB IND I to ITM IdeaIND 50 1. 1910575 2.Boostimmune BoostimmuneADCHarbourMice®H2L2ADC ••HBM9161 •32914174 HCAb-CARmRNA •Toxicon X•SARS-CoV-2•CARAACR•mRNAT•TFR1 18A.08(3) NKNK15.8%15.8%A11.75% 5.712.60%0.04 5% HBM9161BLAHarbourTherapeuticsHBM4003HBM9378 HBM1020Harbour Mice®HBICE® 23.71.441.02.9 3.53.213.128.48.08.6 4.22.30.9167.4% 1.20.02 3.53.2 28.413.1(i)(ii)8.86.6 0.77.9 2.91.51.4 0.70.7 65.01.2 15823 13.20.714.42.9 C1 C.2.1 C.2.1 C3 AlbertR.CollinsonAlbertR.Collinson 3.10(2)3.10(2)3.213.10(2)3.21 13.51B(1) Albert R. Collinson 13.51B(1) XVXV78352 (1)L(2)768,876,410(3)HARBOURBIOLLCSouth Dakota Trust Company LLCHARBOURBIO LLC 99.96%(4)7,200,000956,500Kastle Limited(5)Kamen2,625,9601,502,080KamenShuxin Biotech Limited(6)2,625,000204,000Kastle Limited XVXV78352 XV23336 (1)LS(2)768,876,410(3)AdvantechMaster Investment LimitedAdvantechMaster Investment Limited AdvantechCapitalL.P.AdvantechCapitalAdvantech CapitalAdvantechCapital Holdings Ltd.Advantech Capital Partners Ltd.Advantech Capital Holdings Ltd.Advantech Master Investment LimitedAdvantech Capital Advantech Capital Partners Ltd.Advantech Capital Holdings Ltd.93,561,360(4)LC Fund GP LimitedLC FundGP LimitedLC Healthcare Fund I GP, L.PLC Healthcare Fund I GP, L.PLC Healthcare Fund I, L.P.LC Healthcare Fund I, L.P.LC Healthcare Fund I GP, L.PLC Fund GP LimitedLC Healthcare Fund I, L.P.68,601,000(5)HARBOURBIO LLC(6)7,200,000956,500Kastle Limited 336 14,260,0001.85% 1. 2. 76,789,11610% 38,595,1169,605,0005,737,25034,727,366 1.2.50%3.4.(a)25%(b)25%(c)25%(d)25%(a)25%(b)25%(c)25%(d)25%(a)25%(b)25%(c)25%(d)25%5.2.4151,284,0006.206.36,056,0001,284,0005(i)25%(ii)25%(iii)25%(iv)25%1,284,0001,284,0002(i)20%(ii)20%(iii)20%(iv)40%27.8. 3. 38,394,5585%1% 33,796,8084,655,000842,50029,984,308 38,394,558 37,856,8081,811,50036,045,308 1. 2.(a)25%(b)25%(c)25%(d)25%(a)25%(b)25%(c)25%(d)25%(a)25%(b)25%(c)25%(d)25% 3.50% 18 1. P.O. Box 472, 2nd Floor, 103 South Church Street, George Town, Grand Cayman KY1-1106, Cayman Islands 2.1 34 2.2 161177 3. (a) 3. 10% 4. 4. (i) 10 4. (ii) 103045 30 5. 6. 16.5%16.5%8.25%8.25%2,000,0002,000,000 6. 25%25%15%15%15%15% 200,000200,00015%15%25.8%25.8% 21%21%8%8% 7. 8. 9. 87718 10. NK590,625NK15.7895%32,660,0005.13,400,0000.5 NK NKA+NK11.75% 11. 11. 1045 12. 13. 14. 14. 15. 1,500,0000.001 1,263,200 1)10%2)22.5%3)67.5% 15. 0.001 44,625 1,742,862243,87822.061,742,862 (a)425,734 (b)1,257,024 1)30%2)30%3)40% (c)22,552 1)7,5522)4,5003)4,5004)6,000 15. (d)37,5521)7,5522)9,0003)9,0004)12,000 243,878 1)30%22)30%23)40%2 25,5857,53621,6001,728,00060.231.291.18 15. 7,600,000 1)30%2)30%3)40% 3,800,000 1)30%2)30%3)40% 7,600,000 1)30%2)30%3)40% 15. 1,510,4001,208,320302,080 1)30%2)30%3)40%