华领医药-B中期报告2024

( 於開曼群島註冊成立的有限公司 )股份代號 :2552 2 4 6 25 26 27 29 30 32 49 55 Robert Taylor NELSEN 20241 1 Robert Taylor NELSENFangxin Li William Robert KELLER • William Robert KELLER PO Box 309, Ugland House, Grand Cayman,KY1-1104, Cayman Islands William Robert KELLERFangxin Li 362201203 Robert Taylor NELSENWilliam Robert KELLER 200506 Maples Fund Services (Cayman) LimitedPO Box 1093, Boundary Hall, Cricket Square,Grand Cayman, KY1-1102, Cayman Islands 1617 1 232 277 www.huamedicine.com 2552 2®dorzagliatin®20231120241 18031 •2024®846,0002023212,00020246 302,1002,900®20231431,080 •2024102.7202346.0%®202210196.92024®72%20%8% •202447.846.5%20241 164.1%202362.6%202348.8%dorzagliatin •Dorzagliatin20243 •HMM06011,368HMM0701102HMM06012,0002dorzagliatinHMM0701dorzagliatindorzagliatin2022 1020100,000 •CardiovascularDiabetology •20246 301,338.8•20246 30102.7846,000®•20246 3055.147.8•20246 30245.9119.8•20246 3020236 3048.868.7%119.8•20246 3020236 3052.157.9%142.2•20246 3020236 3051.456.8%142.0 ®2024®2,100®2024102.72024dorzagliatin2025 80dorzagliatin22(GK)(MR)dorzagliatindorzagliatin MRdorzagliatinIIIdorzagliatin(GK-GKRP)(GK-GKRP)dorzagliatin2 2(RWE)HMM0601HMM0701HMM0123dorzagliatin2DPP-IVSGLT-2GLP-1RAdorzagliatin (FDC)Dorzagliatin20282dorzagliatin2 dorzagliatinGLP-1GKAHMS1005I22024 2024(ADA)dorzagliatinSGLT-2dorzagliatin(CKD)SGLT-2dorzagliatin MRdorzagliatin (PAMT)(PAM)GKdorzagliatinG(GPCR)(NAM)GK NAM(PCC)PCC(CHI)mGLUR5 NAM(PDLID)X(FXS) 20246 30 ®®β2 20246 30846,000®102.720236 30634,00032.320246 301,150,000®196.9 2023®2® 20246 3047.846.5%20236 3062.6%16.1%2023®341.95124.88 ®20236 3038.616.5202463055.120246 3026.27.22.5 7.920246 3020236 30 20236 3054.07.120246 3061.1i)6.6ii)2.12024iii)1.4 20246 303.920236 303.52024 20236 3052.98.220246 3061.1i)4.2ii)5.92024iii)3.3 20236 3071.048.820246 30119.8 •dorzagliatin20236 301.919.520246 3021.42024dorzagliatin22024GKA •20236 3011.935.9202463047.820242023 •20236 3034.96.020246 3028.9 •20236 3015.92.820246 3013.1 20246 3020236 30 20246 30226.820246 301,338.8 20246 3020246 305%20246 30 202420236 30 20246 30226.8142.227.157.5202463020246 30 20236 30258.890.112.0360.92023630 20246 304.420236 300.7 20246 3099.120236 30122.7 202312 311,320.420246 301,205.1202312 311,572.520246 301,516.220246 30 20246 3033.1239.3 20246 3020246 30 5%5%20246 305%5%5% 202463020231231 (7,277)(8,233)(2,251)(2,316) 20246 30202312 311,205.11,320.4 202463020231231 (1)(2)(3) (2) (3)20246 30 20246 30202312 311.320246 30202312 311.5 20246 308.9 1,565,000202312311,565,0002.75%101,565,000202312 311,565,0002.75%10 20246 305,773,00020231231476,0002.75% 202463020231231 1,9353,186 20246 30dorzagliatin 20246 3020236 30 13.2013.22 13.2013.2113.22 20246 30172202312 311772024630 7041%4526%3420%127%116%172100% 20246 3081.420236 3081.9 20246 30 D. 1717 0.0% 1. 20241 12024630HLYYLimited117,000,000 202312 31202412 31 2. (1)20191 23201911 1175%368.866(2)20211 720211 775%364.984(3)20223 1720223 1775%363.40(4)20233 3120233 3175%363.62(5)201810 29201810 2975%367.192(6)201911 1375%366.64 (7)20203 1720203 1775%363.616(8)20204 320204 375%363.00(9)20204 720204 775%363.018(10)20208 1820208 1875%367.184(11)20211 720211 775%365.584(12)20213 2220213 2275%364.984(13)20218 3020218 3075%364.56 (14)20219 2320219 2375%365.05 (15)20223 1720223 1775%363.40 (16)20226 2420226 2475%363.95 (17)202212 1202212 175%363.47 (18)20235 820235 875%362.968 (19)2 0 2 4112 0 2 463 04 3 , 3 2 3 , 2 7 643,323,276 254820246 30343434 24102410 34 • 20248 29 63020242023 20246 30 202463020231231 1339,93945,3481361,38769,19027,53028,572153,1303,130146,6156,656138,601152,896 14221515 161718 20246 30 63020242023 (226,774) 4,368 20246 30 1. 1.1 200911 1020189 142DorzagliatinHMS5552 1.2 34 2. 20246 30202312 31 2. 20241 1 161177 3. 63020242023 4. 63020242023 102,66370,331 5. a 12 5. b 20208 17dorzagliatin20246 301,500,000,0001,415,094,00047,827,00020236 3021,652,00020246 301,291,326,000202312311,339,153,000 6. 202420236 30 7. 8. : 74,08470,2984,5663,8847,35611,626 867720536511 9. 25% 202212 142022202415%202415% 9. 21%20236 3021% 10. 201112Hoffman-La Roche Inc.F. Hoffman-La Roche AGGKAGKA20122,000,000 2017III1,000,000 2021NDA1,000,000 20223,000,000 33,000,000500,000,00015,000,0001,000,000,00040,000,000 11. 12. 63020242023 202420236 30 13. 874,00020236 301,805,00020236 3026,00064,00038,000 2,058,00020236 302,005,0002,058,00020236 302,005,000 202463020231231 60 202463020231231 15. 20246 300.00%4.62%2023 12 310.00%4.66% 1,565,000202312311,565,0002.75%101,565,000202312311,565,0002.75%10 20246 305,773,00020231231476,0002.75% 16. 16. 30316061180181365 17. 122,562,0002023630130,761,000(LPR)3.2%3.3% 18. 202463020231231 2,736 1,0232,406 18. i ii20,000,00020221,364,000 19. 20236 30 0.001202312 3120246 30 19. 20246 30 (a)20188 26HLYYLimited2020246 3074,465509,00074,466,204202312 3175,066513,00075,066,70474,466,2