华领医药-B中期报告2025

( 於開曼群島註冊成立的有限公司 )股份代號 :2552 2 7 27 28 29 31 32 34 51 57 Robert Taylor NELSEN Robert Taylor NELSEN William Robert KELLER • William Robert KELLER PO Box 309, Ugland House, Grand Cayman,KY1-1104, Cayman Islands William Robert KELLER 362201203 Robert Taylor NELSENWilliam Robert KELLER 200506 Maples Fund Services (Cayman) LimitedPO Box 1093, Boundary Hall, Cricket Square,Grand Cayman, KY1-1102, Cayman Islands 1617 1 232 277 www.huamedicine.com 2552 ® •20251,764,000®2024846,000108%20252024•112%217.4•®20242025•54.2%46.5%•112%20255%64.2®•20251 11,243.5•20256 301,022.8•MYHOMSIS®TMdorzagliatin75mg •dorzagliatinGLP-1DPP-IVSGLT-2 •(BLOOM)802,0002BLOOM1,000BLOOMdorzagliatindorzagliatin60%dorzagliatinSGLT-2GLP-1DPP-IVdorzagliatin •2025(ADA)dorzagliatindorzagliatinGKA(MOA)Diabetes •20256 301,022.8•20256 30217.41,764,000®20246 30112%108%•20256 30117.820246 3070.1147%•20256 3054.2%20246 307.7•20256 3020246 3061.13.064.220256 302024®202529.5%202459.5%•20256 301,254.620246 301,199.52,178%20256 301,243.520246 301,195.72,500%•20256 30187.165.820256 3020246 3054.045%•20256 3020246 301,326.2932%1,183.9•20256 3020246 301,326.1934%1,184.1 20252®20251 1 1.76®2024108%217.4112%117.854.2% 12.411.8 ®20241(NRDL) dorzagliatin ®2025(ADA)dorzagliatin (1)dorzagliatin dorzagliatin1,500DAWNdorzagliatin1%5mmol/L0.8%dorzagliatin20258IND2026 dorzagliatinGLP-1RA SGLT-2DPP-IVDorzagliatin Idorzagliatin(CFRD) dorzagliatinGKA2025®2025 dorzagliatinGKAdorzagliatinI20252026IGKA 20256 30 ®®β2 20251 1®20 20256 301,764,000®217.42024630846,000®102.7112%® 20256 30117.854.2%20246 3046.5%7.7 dorzagliatin20246 3055.11,199.520256301,254.620256 301,195.720251 11,243.5 2.220256 3020246 30 20246 3061.13.020256 3064.2i)27.020256 30ii)10.3iii)34.9202511 20246 30119.854.020256 3065.8 •20246 3021.46.720256 3014.8GKA2024GKA2025 •20246 3047.840.720256307.1202420252025 •20246 3028.90.520256 3029.3 •20246 3013.13.220256 309.9 20246 3061.18.020256 3053.1i)4.1ii)2.720256302024 20256 304.020246 303.920256 30 20256 3020246 30 20256 3020256 3084.420256 301,022.8 20256 3020256 305%20256 30 202520246 30 20256 3084.41,183.91,224.943.420256 3020256 30 20246 30226.8142.227.157.5202463020246 30 20256 301.320246 304.4 20256 3032.620246 3099.1 202412 311,006.220256 301,082.6202412 311,336.520256 301,242.120256 30 20256 3058.2212.9 20256 3020256 30 5%5%20256 305%5%5% 202563020241231 (5,596)(6,441)(2,362)(2,191) 20256 30202412 311,082.61,006.2 (3)202412 31 20256 30202412 313.820256 30202412 313.320251 1 20256 30 202563020241231 2,1412,117 20256 30dorzagliatin 20256 3020246 30 13.2013.22 13.2013.2113.22 20256 30285202412 311682025630 6322%5018%14852%124%124%285100% 20256 3097.020246 3081.4 20256 30 D. 1720231 117 9,700,0000.9% 1. 20251 12025630HLYYLimited117,000,000 202412 31202512 31 2. (1)20191 23201911 1175%368.866(2)20211 720211 775%364.984(3)20223 1720223 1775%363.40(4)20233 3120233 3175%363.62(5)201810 29201810 2975%367.192(6)201911 1375%366.64 (7)20203 1720203 1775%363.616(8)20204 320204 375%363.00(9)20204 720204 775%363.018(10)20208 1820208 1875%367.184(11)20211 720211 775%365.584(12)20213 2220213 2275%364.984(13)20218 3020218 3075%364.56 (14)20219 2320219 2375%365.05(15)20223 1720223 1775%363.40(16)20226 2420226 2475%363.95(17)202212 1202212 175%363.47(18)20235 820235 875%362.968(19)20253 2820253 2875%362.48(20)(21)2 0 2 5112 0 2 563 04 3 , 3 2 3 , 2 7 633,623,276 285020256 30343434 2410 34 • 20258 28 20252024 20256 30 202563020241231 131314 1415 161718 1,260,5131,197,021 20256 30 1,183,946(142,241)(7,339)(5,446)(1,363)(1,379)5,5335,7759,7499,8611,7391,7573,9683,8804,9167,3561,331(1,003)–(47,827)(1,243,499)–(41,019)(169,267)(43,880)(28,516)–342485(28,598)8,907(5,297)(22,354)8,29313,447(3,736)–5(84,414)(226,774)(6,060)(962)–(207)(29)–52–7,2965,5371,2594,368 20256 30 1. 1.1 200911 1020189 142DorzagliatinHMS5552 1.2 34 2. 20256 30202412 31 2. 20251 1 21 3. 63020252024 217,432102,663 4. 63020252024 5. a 1)2) 5. b 2020817dorzagliatin20251 11,243,499,000 6. 202520246 30 7. 8. : 91,20670,8256,4694,7358,2965,9964,9167,356 9. 25% 9. 202212 14202212 14202512 1415%202515% 21%20246 3021% 10. 201112Hoffman-La Roche Inc.F. Hoffman-La Roche AGGKAGKA20122,000,000 2017III1,000,000 2021NDA1,000,000 20223,000,000 33,000,000500,000,00015,000,0001,000,000,00040,000,000 20256 301,396,00020246 301,396,000 11. 12. 20256 3020246 30 13. 1,023,00020246 30874,00020246 30 3,295,00020246 302,058,0003,295,00020246 302,058,000 202563020241231 60 202563020241231 15. 20256 300.00%1.65%2024 12 310.00%4.62% 16. 20256302024123146,88963,7227,4264,22029,74337,5711,8277,3523403302,5223,49988,747116,694 16. 303160 17. 29,853,0002024630122,562,000(LPR)0.25%0.15%2.85%2.95% 18. 202563020241231 19. 20256 30 19. 20256 30 (a)20188 26HLYYLimited2020256 3068,598469,00068,599,2042024123171,925492,00071,926,20468,599,2042024123171,926,204 (b)20256 301.825,