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Rabies Routine health information system and health facility data forneglected tropical diseases Rabies Routine health information system and health facility data for neglected tropical diseases: rabies ISBN 978-92-4-010730-4 (electronic version)ISBN 978-92-4-010731-1 (print version) © World Health Organization 2025 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence(CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the workis appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specificorganization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license yourwork under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the followingdisclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHOis not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authenticedition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of theWorld Intellectual Property Organization (http://www.wipo.int/amc/en/mediation/rules/). Suggested citation.Routine health information system and health facility data for neglected tropical diseases: rabies. Geneva:World Health Organization; 2025. Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data.CIP data are available at https://iris.who.int/. Sales, rights and licensing.To purchase WHO publications, see https://www.who.int/publications/book-orders. To submitrequests for commercial use and queries on rights and licensing, see https://www.who.int/copyright. Third-party materials.If you wish to reuse material from this work that is attributed to a third party, such as tables, figures orimages, it is your responsibility to determine whether permission is needed for that reuse and to obtain permission from thecopyright holder. The risk of claims resulting from infringement of any third-party-owned component in the work rests solely withthe user. General disclaimers.The designations employed and the presentation of the material in this publication do not imply theexpression of any opinion whatsoever on the part of WHO concerning the legal status of any country, territory, city or area or of itsauthorities, or concerning the delimitation of its frontiers or boundaries. Dotted and dashed lines on maps represent approximateborder lines for which there may not yet be full agreement. The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommendedby WHO in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietaryproducts are distinguished by initial capital letters. All reasonable precautions have been taken by WHO to verify the information contained in this publication. However, the publishedmaterial is being distributed without warranty of any kind, either expressed or implied. The responsibility for the interpretationand use of the material lies with the reader. In no event shall WHO be liable for damages arising from its use. Design and layout by L’IV Com Sàrl. Contents Acknowledgementsv Abbreviationsvi 1.1Approach to development of this guidance11.2Declarations of interest21.3Scope of this document21.4Objectives21.5Target audience2 2.About rabies data 2.1Importance of data on human rabies disease32.2Objectives of surveillance data32.3 WHO-recommendedrabies-relateddefinitions42.4 AdditionalWHO-recommendeddefinitionswithimplicationsforclinicalmanagementof cases5 3.Data quality 3.1Completeness of data63.2Timeliness of data63.3Consistency of reported data63.4External comparisons of population data7 4.Case-based reporting and risk assessment 4.1Patient information84.2 Exposurewoundriskassessment94.3 Post-exposureprophylaxisriskassessment94.4Clinic visit9 5.Indicators11 5.1Core indicators115.2Additional indicators12 6.Core analyses14 6.1Epidemiology of rabies disease146.2Clinical examination176.3Diagnosis186.4Management196.5Management of outcomes21 7.Global reporting and validation of “zero human deaths”23 References27Annex 1. Recommendations on post-exposure prophylaxis28Annex 2. Decision tree for wound risk assessment in clinical settings30Annex 3. Decision tree for post-exposure prophylaxis risk assessment31Annex 4. Glossary for case-based reporting form32Annex 5. Animal-based indicators to be collected at the national level38Annex 6. Further resources39 Acknowledgements TheWorldHealthOrganization(WHO)isgratefultothefollowingindividualswhocontributedt