康宁杰瑞制药-B2025中期报告

（於開曼群島註冊成立的有限公司）股份代號:9966 2025中 期 報 告 250 1051 AACR ADC ADCIII •KN035®PD-L1PD-L1KN0352021112024MSI-H/dMMRKN03516CDE(TMB-H)2024GlenmarkGlenmarkKN035KN035 •KN026HER2 BsAbHER2KN026IIIKN026HER2+ GC/GEJKN026-001KN026HER2+ BCKN026-003KN026BCKN026-004IIIKN026II/IIIKN026-00120254PFSOSKN026NDA2025911KN026202311CDE20258 28 •JSKN003HER2ADCTOPO1KN026HER2NHER2JSKN003HER23IIIJSKN003HER2+ BCJSKN003-301HER2BCJSKN003-302PROCJSKN003-306III20249JSKN00320253JSKN003CDEHER2PROC202562025ASCOJSKN003PROCHER2+ BCHER2(IHC3+)20257JSKN003FDAGC/GEJFDAIIHER2PROCJSKN003-202 •JSKN016ADCTROP2HER3JSKN016JSKN016TROP2HER3TOPO1JSKN016IJSKN016II •JSKN033ADCJSKN003KN035JSKN033I/IIHER2JSKN033I/II2024SITCJSKN033HER2NSCLCII •JSKN022ADCPD-L1αvβ6(Envafolimab)ADCTOPO1T01JSKN022PD-1/PD-L1JSKN022IND20258CDE •JSKN021EGFR/HER3TOPO1(T01)MMAEDAR 4T01DAR 2MMAE •KN046BsAbPD-L1CTLA-4KN046NSCLCKN046 20256 3020256 3020256 3020256 30 20256 3020256 3020256 3020256 30 20256 3020256 30 20256 3020256 30 20256 3020256 30 Conyers Trust Company (Cayman) Limited Cricket Square, Hutchins DrivePO Box 2681Grand Cayman, KY1-1111Cayman Islands 183171712-1716 9966 http://www.alphamabonc.com •20251KN026HER2+BCIICancer Communications •20251JSKN033I/III/IIJSKN033HER2NSCLCII •20252CDEJSKN003HER2+ BCIIIJSKN003(T-DM1)HER2+ BC 20252JSKN003PROCIII •20252KN046IINature Communications •20253JSKN016IO(TKI)NSCLCINDCDEJSKN016JSKN016NSCLCIIEGFRNSCLC •20253JSKN016IOHER2BCINDCDEJSKN016HER2BCIIJSKN016HER2BC •20253KN026KN046BCHER2+IISignal Transduction and Targeted Therapy •20253JSKN003CDEHER2PROC •20254JSKN021JSKN0222025AACR •20254KN026HER2+ GC/GEJII/IIIPFSPFSOS •20254KN026HER2+BCIIIKN026HER2+BCIII •20256KN026KN046HER2+ BCIIClinical CancerResearch •20256KN0353II2025ASCO8 •20256JSKN003PROCHER2+ BCHER2(IHC3+)2025ASCO •20256JSKN003RSC Chemical Biology •20257KN026HER2+GC/GEJIIIINDCDE •20257JSKN003FDAGC/GEJJSKN003KN026IOHER2+ GC/GEJII •20257JSKN003FDAIIHER2PROCJSKN003-202 •20258JSKN022IINDCDE 20259KN026GC/GEJNDA ADC ADCIII 1.2. (i)sdAb(ii)sdAbCRIB(iii)FDA40,000LADC 18A.08(3) ADC 20256 30319.420246 30173.631.3202463030.8202563027.2202463039.820256 302.320246 307.320256 3021.920246 3044.62025630253.22024630194.5202563034.4202463034.620256 303.920246 305.6 20256 30319.4(i)(ii)(iii) 202563067.0202463090.620162KN03520256 30KN03554.220246 3069.820256 3012.820246 3020.8202112KN035 20256 30245.6202463078.2 2025630KN0350.520246300.4202111KN035 20256 306.320246 304.3 202563031.3202463030.8 20246 3039.812.6202563027.2202463030.3202563019.820246309.420256307.4 20256 302.320246 307.3 (i)(ii)(iii)(iv)(v) 2024630194.558.72025630253.2(i)(ii)(iii) 202563034.4202463034.6 (i)(ii)(iii) 20246305.61.720256303.9(i)(ii) 20256303,693.420246303,547.5 202520246 30 202563021.620246 3044.9 20256 30498.220241231500.0 16 2024123124.01.420256 3022.6 202563082.12024123181.8 2024123116.5202563053.0 (i)(ii)(iii) 202412 3139.617.120256 3056.7 (i)(ii) 202412311,112.120256 30825.620241231459.320256 30819.2 20241231180.811.820256 30192.6 202412313.720256302.5 20241231202563040.137.22.67%4.35%20242.67%4.35% 2025630 2025 20256 30270.920241231182.22.22%2.54%20256 30228.219.9 (1)(2)(3)100% 2025630 20256 30 20256 30228.219.9 2025630 20256 3020256 302025630 20256304842024630429202563093.620246 3086.8 D.20204 2220245 21 2025630XV352 (1)RubymabRubymabSouth Dakota Trust(2)(3)20256 30965,141,807(L) (1) 2025630 20256 30336 (1)RubymabSouth Dakota Trust(2)Sky DiamondSky Diamond(3)PearlmedPearlmed(4)20256 30965,141,807(L) 20256 30336 202563018 20256 3020256 302,952,000 20256 3020256 30 201832820191212 2025630C.2.1C.2.1 2025630 202512 31 202591910,000C3 C3C3 20255 15 2025630 13.51B(1) 20256 30•2410 20256 3020246 30 17 (1) (2)8.90 20205 2520246 1220245 21 50,000168,000680,000 (1)14A.06 (2)(a)20224231,451,000(b)2023 4 231,451,000(c)2024 4 231,451,000(d)20254231,852,000(e)2026 4231,400,000(f)2027 4231,400,000 (3)(a)20221025120,000(b)20231025120,000(c)20241025120,000(d)202510 25240,000 (4)(a)2023 425400,000(b)2024 425400,000(c)2025 425400,000(d)2026425800,000 (5)(a)2023102444,000(b)2024 102444,000(c)2025102444,000(d)2026102488,000 (6)(a)20241024100,000(b)20251024100,000(c)20261024100,000(d)202710 24200,000 (7)(a)2025423236,000(b)2026 423236,000(c)2027423236,000(d)2028423472,000 (8)(a)2025102394,000(b)2026102394,000(c)2027 102394,000(d)20281023188,000 (9)(a)202642310,000(b)2027 4 2310,000(c)2028 42310,000(d)202942320,000 6.96 96,108,45596,356,455 18 20213 2320246 1220245 21 610,000 (1)14A.06 (2)2412202552920255 29 (3)(a)20%202210 23(b)20%202310 23(c)20%202410 23(d)40%202510 23 (4)(a)20%2023425(b)20%2024425(c)20%2025425(d)40%20264 25 (5)(a)20%202310 24(b)20%202410 24(c)20%202510 24(d)40%202610 24 (6)(a)26,0002025423(b)26,0002026423(c)26,0002027423(d)52,00020284 23 (7)(a)76,000202510 23(b)76,000202610 23(c)76,00020271023(d)152,000202810 23 (8)(a)98,0002026423(b)98,0002027423(c)98,00020284 23(d)196,00020294 23 6.96 7.78 9