康宁杰瑞制药-B2024年报

（於開曼群島註冊成立的有限公司）股份代號:9966 2024年 度 報 告 ADC ADCIII •KN035®PD-L1PD-L1202111KN0352024MSI-H/dMMR16CDE(TMB-H)GlenmarkGlenmarkKN035KN035 •KN026HER2 BsAbHER2KN0263IIIKN026HER2BCKN026HER2GC/GEJKN026BCIIIKN026HER2GCGEJCDE •JSKN003HER2ADCIKN026HER2NHER2JSKN003HER23IIIJSKN003HER2BCHER2BCIII20244JSKN003IAACR20246JSKN003I/IIIASCO20249JSKN003OCHER2(IHC 3+)BCESMO20249JSKN00330.8JSKN003JSKN003CDEHER2 •JSKN016ADCHER3TROP2JSKN016JSKN016TROP2HER3ITOPO1iJSKN016IJSKN016 •JSKN033ADCJSKN003KN035BellberryHER220243JSKN033I/II202411HER2JSKN033I/II2024SITC •KN046BsAbPD-L1CTLA-4KN046NSCLC2024238NatureCommunicationsCell Reports MedicineCancer Immunology, ImmunotherapyNSCLCIbKN046NSCLCII2024ESMO20249KN046sq NSCLCIIIOSKN046 202410 22 202410 22 202410 22202410 22 202410 22202410 22 Cricket Square, Hutchins DrivePO Box 2681 Grand Cayman, KY1-1111Cayman Islands 175 33191901 1526 • 8835 Conyers Trust Company (Cayman) Limited Cricket Square, Hutchins DrivePO Box 2681Grand Cayman, KY1-1111Cayman Islands 183171712-1716 9966 http://www.alphamabonc.com 2024 ADCPD-(L)1(KN035)2024HER2KN026GC/GEJHER2HER23III ADC3ADCHER2ADC JSKN003HER2HER2HER2HER23IIIII ADC JSKN016I/II ADCJSKN033ADCI/II2024 SITC(LBA)I/II ADC (BADC)(BADDC)ADC ADC192.58% 622 •20241KN035MSI-HdMMR•20241GlenmarkGlenmarkKN035KN035•20242KN046BCIIPFSOSNatureCommunications•202432024202416•20243KN046NSCLCIICell ReportsMedicine•20243JSKN033HER2I/II•20243JSKN016CDE •20244AACRJSKN003HER2IJSKN003•20245JSKN016I•20246ASCOJSKN003I/IIIJSKN003•20246ArriVent BioPharma, Inc.(Alphatecan)ADC•20248KN035CDE(TMB-H)•20248KN046IbCancerImmunology, Immunotherapy•20249KN035202412•20249KN046sq NSCLCIIIOS•20249JSKN003PROCHER2+(IHC3+)BCESMO •2024930.8JSKN003 •202410KN026HER2+BCIIICDEHER2+GCGEJHER2+BCIII •202411JSKN033HER2I/II2024SITC •202411E20241002024TOP 5 •2024112024(CHTV)2024TOP 100 •202412KN046NSCLCII2024ESMOKN046NSCLC •202412JSKN003CDEIIIHER2BCIIIII •202412JSKN033I/IIINDCDE •20251KN026HER2+BCIICancerCommunications•20251JSKN033I/II•20252CDEJSKN003HER2+ BCIIIJSKN003(T-DM1)HER2+ BC•20252JSKN003III•20252KN046HCCIINatureCommunications•20253JSKN003CDEHER2•20253JSKN016(TKI)NSCLCINDCDEJSKN016 NSCLCII•20253JSKN016HER2+ BCINDCDEJSKN016HER2+ BC •20253KN026KN046BCHER2+IISignalTransduction and Targeted Therapy ADC ADCIII 1. (i)sdAb(ii)sdAbCRIB(iii)FDA40,000LADC 18A.08(3) ADC 202412 31640.1202312 31218.8202412 3160.32023123155.2202412 3162.0202312 3191.8202412 3113.2202312 3133.1202412 31166.320231231211.4202412 31404.220231231407.5202412 3174.6202312 3179.3202412 319.9202312 3112.2 20241231640.120231231218.8(i)(ii)(iii)(iv) 202412 31159.5202312 31195.620162KN03520241231KN035122.520231231128.4202412 3137.0202367.2202112KN035 20241231464.220237.2202412 3120241 2520246520249 29 20241231KN0351.920230.9202111KN035 202412314.220230.4 2024123110.3202314.7 2024123160.3202355.256.0202351.34.320233.920241231 2024123129.862.02023123191.82023123174.02024123149.3202312 3117.8202412 3112.8 2024123113.2202312 3133.1 (i)(ii)(iii)(iv)(v) 202412 31404.220231231407.5 202412 3174.62023123179.3 (i)(ii)(iii) 202312 3112.2202412319.9(i)(ii) 202412 313,489.1202312313,315.6 2023202412 31 20241231166.320231231210.6 202312 31550.150.120241231500.0 16 2023123126.92.92024123124.0 2024123181.8202312 3178.7 2024123116.5202312317.12024 202412 313.82023 (i)(ii)(iii) 202312 3166.526.9202412 3139.6 (i)(ii) 202312311,086.0202412311,112.1202312 31321.2202412 31459.3 202412 31180.820231231175.1 202312314.4202412313.1 202312 317.1202412 313.7 202312312024123125.540.12.67%4.35%20233.70%4.35% 20241231 20241231 2025 202412 31182.2202312 31250.02.54%2.67%20241231235.620.2 (1)(2)(3)100% 202412 31 202412 31 202412 31235.620.2 202412 31 202412 3120241231202412 31 20241231420202343520241231175.920231231189.3 D.20204 2220245 21 522018328201810 3120197 32018101 2320031120076EMD Serono Research Institute Inc.Merck KGaA200762010Biogen IDEC Inc.BIIB2008112011112018720111120189 1993719971219981200010200011200232009201720207 53201810 3120197 32018101Alphamab Australia 19947199771999320015Ironwood Pharmaceuticals, Inc.Microbia, Inc.20032010ImmunoGen.Inc.20207202050 19947 6320241022201362023626076016072017820238202082023820219202482020920249 632021827 199951996101999420201020169Luigi Sacconi20162 201711202211TWAS16 1994919966Birkbeck 5720191124 •2023712100 •20136202261316 202010202161115202162011320201020071220139IFM Investments LimitedIFM Investments Limited201520067200710Solarfun Power Holdings Co., LimitedSOLFHanwha SolarOne Co., Ltd.Hanwha SolarOneHSOL2003920057LG.Philips DisplaysInternational Ltd. 1999219916 5520191124 200782018310JNJ 1992720059 38 39 3920241 1610050III80FDAEMACDE 2008720169EPS38602016102023122696 2008620186 202410 22 20217 2020720Vistra Corporate Services(HK) Limited2015 202410 22 13.51B(1) 202412 31 202412 31 C1 202412 31C.2.1C.2.1 20241231 C3 202412 31 202410 22 3843 C.2.1 C.5.1 202412 31 3.13 202211 242024827 B.2B.2.