康宁杰瑞制药-B2023年报

（於開曼群島註冊成立的有限公司）股份代號:9966 年度報告2023 ADC •KN046BsAbPD-L1CTLA-4KN0462010NSCLCTNBC ESCC HCC PDACKN046NSCLCPDACKN046KN046I20236Journal for ImmunoTherapy ofCancerKN046KN046NSCLCII20237European Journal of CancerKN0462023102023ESMONSCLCNSCLCEGFR-TKI(s)NSCLCKN046PDACIIIKN046sq NSCLCIIIOSOS •KN026HER2 BsAbHER2KN026KN026HER2BCKN026HER2GC/GEJIIIIIIKN026HER220235KN026HER2BCIIIIND20237KN026KN046HER2BCGC/GEJII202362023ASCOKN026HER2BC2023ESMOKN026HER2BC2023122023SABCS202311KN026HER2GCGEJCDE •KN035PD-L1PD-L120238KN035NSCLCIIIIND202310KN035(pMMR)IIIINDFDA202311KN035MSI-HdMMRCDE •KN019CTLA-4202311IND •JSKN003HER2ADCIKN026HER2NHER2JSKN003HER2JSKN003I/II20233I202442024AACR •KN052PD-L1/OX40PD-L1OX40PD-L1/PD-1OX40KN052TTregKN05220232KN052mRNASWP100120233KN052Late-Breaking Research202342023AACR •JSKN033ADCJSKN003KN035BellberryHER220243 26 33191901 1526 8835 Cricket Square, Hutchins DrivePO Box 2681Grand Cayman, KY1-1111Cayman Islands 183171712-1716 202312 31 2023202231.12%35.35%PD-L1(KN035)195.5532.54% 2023KN046IIIKN026HER2HER2IIIKN026HER2CDE2023ASCO2023ESMO2023SABCSKN046KN026II 2023HER2JSKN003IHER2ADCPD-L1JSKN033HER3 TROP2JSKN016 2024KN046KN026JSKN003JSKN033JSKN016 BsAbCDE6222018328AKN046KN026C114CTLA-4T4TTTT 571 KN046 •20235KN046sq NSCLCIIIOSOS •KN046I20236Journal for ImmunoTherapy of Cancer •KN046NSCLCII20237European Journal of Cancer •KN046NSCLCII2023102023ESMO •KN046NSCLCIIINSCLCOS2023102023ESMO •KN046NSCLCEGFR-TKI(s)EGFRNSCLCOS2023102023ESMO •KN046IIBC2023830OS2023102023ESMO •202311KN046PDACIIIOSOS KN026 •20235KN026HER2BCIIIIND •KN026KN046HER2BCGC/GEJII202362023ASCO •20237KN026HER2BCIII •KN026HER2BCII2023102023ESMO •KN026HER2BCII2023102023ESMO •202311KN026HER2GC/GEJCDE •KN026HER2BC20239 15PFS27.724OS84.1%2023122023SABCS KN035® •20236TRACON Pharmaceuticals, Inc.TCONKN035ENVASARC II •20238KN035NSCLCIIIIND202312•202310KN035(pMMR)IIIINDFDA•202311KN035MSI-HdMMRCDE KN019 •202311KN019IND KN052 •20232KN052mRNASWP1001 •20233KN052Late-Breaking Research202342023AACRKN052 JSKN003 •20233JSKN003Ia/Ib20233 15JSKN003Ia/IbI/II •20231026JSKN003IHER2202311 16 JSKN033 •202312HER2JSKN033 I/IIBellberry20243 •20207 64,000L (2x2,000L)2022202212 36,000L (3x2,000L)20238II40,000L •20232 3Rubymab Ltd.(i)25,000,00015.22(ii)25,000,000202327202329376.220232320232 9 •202311E20231002023ESGTOP20 •20241GlenmarkKN035(a)KN035(b)KN035KN035KN035 •KN046TNBCIIPFSOS20242NatureCommunications •20243JSKN016CDE •KN046NSCLCII20243Cell ReportsMedicine •20244JSKN003HER2I(ILD)2ILD2024AACR20244 10 ADCs (i)sdAb(ii)sdAbCRIBCRAMBADCADCBADDCACCGIMCCIMC(iii)FDAGMP40,000L 202111KN035®KN046NDA2024KN026NDA2025 18A.08(3)KN046KN026 2023 2020202120222021612024120 KN046KN026HER2ADC 20231231218.820221231166.8202312 3155.22022123144.22023123191.8202212 3157.8202312 3133.12022123163.1202312 31211.4202212 31326.220231231407.520221231468.2202312 3179.3202212 3186.8202312 3112.2202212 3114.2 20231231218.820221231166.8(i)(ii)(iii)(iv) 202312 31195.620221231147.520162KN03520231231KN035128.4202286.0 202312 3167.2202261.5202112KN035KN03530 20231231KN0350.920220.3202111KN03510.0 20218KN026BCGC/GEJ202312312.220221.7202312317.2202213.0 2023123112.520224.2 2023123155.2202244.251.3202243.23.920221.020231231 2023123134.091.82022123157.82022123133.9202312 3174.0202212 3123.9202312 3117.8 202312 3133.12022123163.1 (i)(ii)(iii)(iv)(v) 2023123120221231468.260.7407.5 202212 3186.87.52023123179.3 (i)(ii)(iii) 2022123114.22023123112.2(i)(ii) 202312 313,315.6202212312,670.6 2023202212 31 20221231325.7115.1202312 31210.6 202212 31579.028.920231231550.1 16 202212 3140.713.82023123126.9 202212 3164.614.1202312 3178.7KN035 202312317.12022123115.52023 (i)(ii)(iii) 202312310.566.5202212 3166.0 (i)(ii) 202212311,069.2202312311,086.0202212 31247.9202312 31321.2 2022123133.320231231202312 31 20231231175.120221231177.2 202212 314.5202312314.420231231 2022123120.4202312317.1 20222023123127.525.5KN03512.6KN02612.94.35%3.70%KN035KN026KN035KN035KN026 202312 31 2024 202312 31250.0202212 31325.02.70%2.87%20231231255.420.7 (1)(2)(3)100% 202312 31 202312 31 202312 31255.420.7 202312 31 202312 3120231231202312 31 20231231435202247220231231189.320221231192.0 D.20204 2220222023 512018328201810 3120197 32018101 2220031120076EMD Serono Research Institute Inc.Merck KGaA200762010Biogen IDEC Inc.BIIB2008112011112018720111120189 1993719971219981200010200011200232009201720207 52201810 3120197 32018101Alphamab Australia 19947199771999320015Ironwood Pharmaceuticals, IncMicrobia, Inc.20032010ImmunoGen.Inc.20207202050 19947 622021827 199951996101999420201020169Luigi Sacconi20162 201711202211TWAS16 1994919966Birkbeck 5620191124 •2023712100 •20136202261316 •2020102021611152021620113202010 20071220139IFM Investments LimitedIFM Investments Limited201520067200710Solarfun Power Holdings Co., LimitedSOLFHanwha SolarOne Co., Ltd.Hanwha SolarOneHSOL2003920057LG.Philips Displays International Ltd. 1999219916 5420191124 2007820