康宁杰瑞制药-B2023中期报告

（於開曼群島註冊成立的有限公司）股份代號:9966 2023中期報告 2 I •KN046BsAbPD-L1CTLA-4KN0462010NSCLCTNBC ESCC HCC PDACKN046IIKN046NSCLCPDAC HCC TNBCKN046NSCLCPDACKN046KN046I20236(Journal for Immuno Therapy of Cancer )KN046KN046NSCLCII20237(European Journalof Cancer) •KN026HER2 BsAbHER2HER2HER2IKN026IIKN026HER2BCKN026HER2GC/GEJIIIKN026KN046KN026IIIKN026HER220235KN026HER2BCIIIIND20237KN026KN046HER2BCGC/GEJII202362023ASCO •KN0352096PD-L1PD-L1KN035III20238KN035NSCLCIIIIND •KN019CTLA-4 •JSKN003HER2IKN026HER2NHER2JSKN003HER220233JSKN003Ia/Ib20235I/II •KN052PD-L1/OX40PD-L1OX40PD-L1/PD-1OX40KN052TTTKN05220232KN052mRNASWP100120233KN052Late-Breaking Research202342023AACR 20236 30 175 33191901 1526 20231 1 •20232KN052mRNASWP1001 •20233JSKN003Ia/Ib20233 15JSKN003Ia/Ib20235I/II •20233KN052Late-Breaking Research202342023AACRKN052 •20235KN046sq NSCLCIIIOSOS •20235KN026HER2BCIIIIND •KN026KN046HER2BCGC/GEJII202362023ASCO20236 6 •KN046I20236(Journal for ImmunoTherapy of Cancer) •20236TARCON Pharmaceuticals, Inc.TCONKN035ENVASARC II •KN046NSCLCII20237(European Journal of Cancer) •20237KN026HB1801HER2BCIII20237 28 •KN046KN0262023102023 KN046NSCLC KN046NSCLC KN046NSCLCII KN026HER2BCII •20238KN035NSCLCIIIIND •20207 64,000L (2x2,000L)2022202212 3202336,000L (3x2,000L)202362023II40,000L •20232 3Rubymab Ltd.(i)25,000,00015.22(ii)25,000,00020232 7202329376.220232 320232 9 I (1)KN046*KN046 *1.520214.0915% (i)sdAb(ii)sdAbCRIBCRAMBADCBADDCACCGIMCCIMC(iii)FDAcGMP40,000L 202111KN035®KN046NDA2024KN026NDA2025 18A.08(3)KN046KN026 2023630136.5202263053.633.220226 3014.8202363043.0202263021.7202363048.820226 3063.620236 3040.42022630147.32023630194.72022630216.420236 3033.2202263044.120236307.020226 3010.9 20236 30136.5(i)(ii)(iii) 20236 30117.020226 3053.520162KN03520236 30KN03571.520226 3027.2 202363045.5202263025.4202112KN035KN03530 2023630KN035309,0002022630105,000202111KN03510.0 20218KN026BCGC20236 300.920226 3020236307.220226 30 2023630KN03511.020226 30 202363033.2202263014.830.7202263014.62.520226300.22023630 20236 3020226 3021.721.343.020226 3015.9202363037.720226305.720236 305.2 兌 20236 3048.820226 3063.6 (i)(ii)(iii)(iv)(v) 20236302022630216.421.7194.7 20226 3044.110.9202363033.2 (i)(ii)(iii) 20226 3010.920236 307.0(i)(ii) 20236302,990.420226302,233.8 202320226 30 20226 30147.3107.420236 3039.9 20221231579.07.92023630571.1 16 202212 3140.77.120236 3033.6 202212 3164.61.720236 3062.9 202363023.62022123115.52023 (i)(ii)(iii) 202212 3166.010.420236 3055.6 20236 30202212 31 (i)(ii) 202212311,069.220236 301,136.3202212 31247.920236 30445.320232 20236302022123133.320236 30 202212 31177.220236 30162.8(i)(ii) 202212 314.520236304.3 2022123120.4202363013.6 20221231202363027.526.8KN03512.9KN02613.94.35%3.70%KN035KN026KN035KN035KN026 20236302023 20236 30270.0202212 31325.02.70%2.87%2023630244.520.9 (1)(2)(3)100% 2023630 20236 30 20236 30244.520.9 2023630 20236 3020236 302023630 20236304372022630493202363085.320226 3086.7 D.20204222021323202110 252022 20236 30XV352 (1)RubymabRubymabSouth Dakota TrustNew Xu’s Family Trust(2)(3)20236 30964,779,387(L) (1)(2)20236 30964,779,387(L) 2023630 20236 30336 (1)RubymabSouth Dakota Trust 20236 30336 202363018 20236 30 20236 3020236 30 201832820191212 20236 3022C.2.1 C.2.1 2023630 202312 31 1020236 30 2023630 13.51B20234272022 20236 30 20236 30 210020237 1 13.51B(1) 20236 30•2410 20236 302022630 172019202020202021202120222022 (1) (2)8.85 20205252020422 850,00030,000 (1)14A.06 (2)(a)20224231,451,000(b)2023 4 231,451,000(c)2024 4 231,451,000(d)20254231,852,000(e)2026 4231,400,000(f)2027 4231,400,000 (3)(a)2022 1025120,000(b)20231025120,000(c)20241025120,000(d)202510 25240,000 (4)(a)2023 425400,000(b)2024 425400,000(c)2025 425400,000(d)2026425800,000 (5)(a)2023102444,000(b)2024 102444,000(c)2025102444,000(d)2026102488,000 (6)(a)2024424170,000(b)2025 424170,000(c)2026 424170,000(d)2027424340,000 15.40 2022123141,973,26943,733,269 43,733,26942,093,269 19 202212 310.24% 0.09% 202132320213 23202111 2520221 2720225 20202210 24 (1)14A.0620231117.02(2)(2)(a)20%2022423(b)20%2023423(c)20%2024423(d)40%20254 23(3)(a)20%202210 23(b)20%202310 23(c)20%202410 23(d)40%202510 23(4)(a)20%2023425(b)20%2024425(c)20%2025425(d)40%20264 25(5)(a)20%202310 24(b)20%202410 24(c)20%202510 24(d)40%202610 24(6)20221024369,957(7)15.78(8)20221231773,5712022 202212 3112,910,69011,629,359 11,629,35911,629,359 19 202212 310.46% 0.09% 201912 122,042.520236301,540.6 KN046 KN026 500.0700.024.5%34.3%202312312024 20232Rubymab376.220236 30 20232 9(i)80%JSKN003HRE2BCGC(ii)10%JSKN016(iii)10% 10.020.02.7%5.3%202312312025 2023823 44742023630343434 2410 34 • 20238 23 20236 30 (i)201841820195(ii)(iii)20189 25 20236 30 1. 2018328201912 12 34 2. 202363020221231 20231 1 17202062021121781212 112 2. 120231 1 220231 1124A88A 3. 3. (i)KN035 20162KN035KN035(MSI-H)10KN03520164KN035KN035202111152023630KN035309,00020226 30105,000 KN03