杰夫斯品牌有限公司美股招股说明书(2025-09-22版)

PROSPECTUS SUPPLEMENT NO. 2(To prospectus dated July 24, 2025) JEFFS’ BRANDS LTD Up to 5,247,776 Ordinary Shares This prospectus supplement updates, amends, and supplements the prospectus dated July 24, 2025 (the “Prospectus”), whichforms a part of our Registration Statement on Form F-1, as amended (Registration No. 333-288355). Capitalized terms used in thisprospectus supplement and not otherwise defined herein have the meanings specified in the Prospectus. This prospectus supplement is being filed to update, amend, and supplement the information included in the Prospectus withthe information contained in our Report of Foreign Private Issuer on Form 6-K (the “Form 6-K”) furnished to the Securities andExchange Commission (the “SEC”) on September 22, 2025. Accordingly, we have included the Form 6-K in this prospectussupplement. This prospectus supplement is not complete without the Prospectus. This prospectus supplement should be read inconjunction with the Prospectus, which is to be delivered with this prospectus supplement, and is qualified by reference thereto, exceptto the extent that the information in this prospectus supplement updates or supersedes the information contained in the Prospectus.Please keep this prospectus supplement with your Prospectus for future reference. Our Ordinary Shares and warrants issued as part of our initial public offering are listed on the Nasdaq Capital Market underthe symbol “JFBR” and “JFBRW,” respectively. On September 19, 2025, the last reported sale price of the Ordinary Shares and PublicWarrants was $4.630 and $0.03, respectively. There is no established market for the Promissory Notes and we do not intend to apply tolist the Promissory Notes on any securities exchange or other nationally recognized trading system. ANINVESTMENT IN OUR SECURITIES INVOLVES RISKS.SEE THE SECTION ENTITLED“RISKFACTORS” BEGINNING ON PAGE 5 OF THE PROSPECTUS AND IN OUR ANNUAL REPORT ON FORM 20-F FORTHE FISCAL YEAR ENDED DECEMBER 31, 2024. Neither the SEC nor any state or other securities commission has approved or disapproved of these securities ordetermined if the Prospectus or this prospectus supplement is truthful or complete. Any representation to the contrary is acriminal offense. The date of this prospectus is September 22, 2025 UNITED STATESSECURITIES AND EXCHANGE COMMISSIONWashington, D.C. 20549 Form6-K Report of Foreign Private IssuerPursuant to Rule13a-16 or 15d-16under the Securities ExchangeActof1934 For the month of September 2025 Commission file number:001-41482 7 Mezada St.Bnei Brak, Israel 5126112(Address of principal executive offices) Indicate by check mark whether the registrant files or will file annual reports under cover of Form20-F or Form40-F. Form20-F☒Form40-F☐ CONTENTS This Report of Foreign Private Issuer on Form 6-K (this “Form 6-K”) consists of Jeffs’ Brands Ltd’s (the “Company”): (i)Unaudited Condensed Consolidated Financial Statements as of, and for the six months ended, June 30, 2025, which are attachedhereto as Exhibit 99.1; and (ii) Management’s Discussion and Analysis of Financial Condition and Results of Operations for the sixmonths ended June 30, 2025, which is attached hereto as Exhibit 99.2. This Form 6-K is incorporated by reference into the Company’s Registration Statements on Form F-3 (File No.333-277188,File No.333-262835, File No.333-283848, File No.333-283904, File No.333-285030and File No.333-287341) and RegistrationStatements on Form S-8 (File No.333-269119and File No.333-280459) to be a part thereof from the date on which this Form 6-K issubmitted, to the extent not superseded by documents or reports subsequently filed or furnished. EXHIBIT INDEX ExhibitNo.99.1Jeffs’ Brands Ltd’s Unaudited Condensed Consolidated Financial Statements as of, and for the six months ended, June30, 2025.99.2Jeffs’ Brands Ltd’s Management’s Discussion and Analysis of Financial Condition and Results of Operations for the SixMonths Ended June 30, 2025.101.INSInline XBRL Instance Document.101.SCHInline XBRL Taxonomy Extension Schema Document.101.CALInline XBRL Taxonomy Extension Calculation Linkbase Document.101.DEFInline XBRL Taxonomy Extension Definition Linkbase Document.101.LABInline XBRL Taxonomy Extension Label Linkbase Document.101.PREInline XBRL Taxonomy Extension Presentation Linkbase Document.104Cover Page Interactive Data File (formatted as Inline XBRL and contained in Exhibit 101). SIGNATURES Pursuant to the requirements of the Securities ExchangeActof1934, the registrant has duly caused this report to be signed onits behalf by the undersigned, thereunto duly authorized. Date: September 22, 2025 JEFFS’ BRANDS LTD INTERIM CONDENSED CONSOLIDATED FINANCIAL STATEMENTSAS OF AND FOR THE SIX MONTHS ENDED JUNE 30, 2025 (UNAUDITED) INDEX Interim Condensed Consolidated Balance Sheets (unaudited)2Interim Condensed Consolidated Statements of Operations(unaudited)3Interim Condensed Consolidated Statements of Changes in Shareholders’ Equity(