翰森制药2025年中期报告

2458233435363739404266 11 11 3692 600,000,00040546 1 Maples Fund Services (Cayman) LimitedP.O. Box 1093, Boundary HallCricket SquareGrand Cayman, KY1-1102Cayman Islands P.O. Box 309, Ugland HouseGrand Cayman, KY1-1104Cayman Islands 287 1617 2 33191928 45 97927 www.hspharm.com 50037 ••••• GSKGSK5764227HS-20093FDA(BTD)B7-H3ADC ®IIIMITIGATEIgG4-RDNMPABLANMPA 1BTKi HS-10561NMPA B7-H3ADCHS-20093NMPA ®NMPAEGFR1921(L858R)NSCLC®®NMPAII-IIIBEGFR1921(L858R)NSCLC® ADCHS-20122NMPANSCLC HS-20108NMPA KRASG12DHS-10529NMPAKRAS G12DNSCLC B7-H3ADCHS-20093NMPANSCLC ®NMPA(VVC) B7-H4ADCHS-20089NMPA 1HS-20118NMPA 1HS-10542NMPAA 1HS-10510NMPA ®BLANMPA(gMG) RegeneronRegeneronHS-20094 Aumseqa®MHRAAumseqa®NSCLCEGFREGFR T790MNSCLC ESGMSCIESGAA202520251%ESG www.hspharm.com/ ADCAI ® ®EGFRTKIEGFR-TKIT790MNSCLCEGFR1921(L858R)NSCLC®NDANMPA ®EGFR1921(L858R)NSCLC II-IIIBEGFR1921(L858R)NSCLC ®Aumseqa®)MHRANSCLCEGFREGFRT790MNSCLC ®I(CSCO)2025®AACR(ELCC)(ASCO)III2025AACR ®NSCLCIIIII-IIIBEGFRNSCLC®(DFS)HR0.172DFS90.2% ®NSCLCIIIEGFRNSCLC®(PFS)HR0.47®53%(mPFS)28.9(ORR)93.2% ® ®TKI®®MMRMR4.5BCR-ABLTKI® ®30(EHA) ® ®CD19 BAQP4NMOSDCD19Viela Bio Inc.HorizonTherapeuticsplcNMPAAQP4NMOSD ®IIIMITIGATEIgG4-RDNMPA BLANMPA®BLA FDAIgG4-RDFDAIgG4 BLANMPA(gMG) ® ®GLP-1RAPEGGLP-1RA2®2® ®MedCommIF:10.7DiabetesTherapy®®2® ®(CDS)2024122025 ® ®(NRTI)NMPA ®III48961445IV®(TDF) ®(AASLD)(EASL)(APASL)(Alimentary Pharmacology & Therapeutics )(Frontiers In Pharmacology )(World Journal of Gastroenterology )(Journal of Clinical and TranslationalHepatology ) ®20222022I®2024A®2024A2 ® ®1®(CKD)(ESA)® ®EPO®IIIeClinicalMedicine1®1~3(rHuEPO)EPO ®Journalof Translational Medicine Kidney InternationalReportsKidney Medicine(ASN)(ISN)(WCN) ®2024®2024®2025 BTKHS-10561ADCHS-20108EGFR/c-MetADCHS-20122NSCLCHS-10542AHS-10510KRASG12DHS-10529KRAS G12DNSCLCHS-20118 IIIB7-H3ADC HS-20093B7-H4ADC HS-20089IL-23p19HS-20137 HS-20093 HS-20093B7-H3ADCB7-H3(TOPOi) HS-20093IIIHS-20093IIIPoC HS-20093NMPA HS-20093NMPANSCLC HS-20093NMPA HS-20089 HS-20089B7-H4ADC HS-20089IIIPoC HS-20089NMPA HS-20094 HS-20094GIPGLP-1GIPGLP-1HS-20094III HS-10374 HS-10374TYK2IIHS-10374TYK2HS-10374III BDBDRegeneronHS-20094 Regeneron RegeneronRegeneronHS-200948,00019.3 HS-20122 HS-20117EGFR/c-Met HS-20122HS-20117EGFR/c-MetADCHS-20122NMPANSCLC HS-20137 HS-20137QX004NHS-20137IL-23p19 HS-20137II2025(AAD)28HS-20137JAMA DermatologyI HS-20137III HS-10561 HS-10561LP-168 HS-10561BTKiHS-10561NMPA (ESG) ESGESG ESGESGESG 2024ESGESG MSCIESGAA202520251% ESGESG 5% GMP 11,500,0001152.959522.101,194,647D. 8,560,990211,91014A.73(6)14A.95 XV(i)XV78(ii)352(iii)C3 1. (1)5,947,150,070 (2)StellarInfinityStellar InfinitySunriseInvestmentSunriseInvestmentHarmoniaHoldingHarmonia HoldingSunriseTrustSunriseTrustSunriseTrustXVStellarInfinity (3)StellarInfinity2,214,5831,287,000 (4)1,733,723602,530 (1)Sunrise InvestmentHarmonia HoldingHarmonia HoldingSunrise TrustSunriseTrustSunriseTrustXVHarmoniaHoldingSunrise Investment XVXV78352 XVXV23336 (1)5,947,150,070 (2)StellarInfinitySunriseInvestmentSunriseInvestmentSunriseTrustHarmoniaHoldingSunrise InvestmentHarmoniaHoldingStellarInfinity (3)Cantrust (Far East) LimitedJQC International LimitedApex Medical920,000,000XVCantrust (Far East) LimitedJQC International Limited XV23336 (i)(ii)D. 114,118,3842% 46,172,47438,379,834 0.144% 38,875,8440.642% (i)(ii)(i)(ii)(iii)(iv)(v) 20,434,4600.34% (1)(2)(3)(4)(5)202542818.677341823.90(6)25.29(7)442,000298,71729.10(8)24.51(9)24.92(10)23.25(11)211,91014A.73(6)14A.95 (i)120.1%(ii)1% 13.51B(1) CitigroupGlobal Markets Asia Limited Citigroup Global MarketsLimitedMorganStanley Asia LimitedCitigroup Global Markets LimitedMorganStanley Asia Limited108,000,000(i)65%(a)(b)(ii)25%(a)(b)(iii)10% ®NMPAIgG4-RD®NMPA C1 C.2.1 C.2.1 C.2.1 C3 3.21D.3 1617 MorganStanley&Co.International plc Citigroup Global MarketsLimited130,380,000 590,622,000 Ernst & Young27/F, One Taikoo Place979 King’s RoadQuarry Bay, Hong Kong 35652025630343434 2410 34 2025818 1. 2.1 20256303420241231 2.2 20241231 21 21 3. 80%8 Merck Sharp & Dohme LLC10%10% 4. 5. * 6. 16.5%2024 16.5%2,000,00020242,000,0008.25%20248.25%16.5%202416.5% 25%200811 20232023202515% 20242024202615% 20241220251120255 6. 15% 7. 202413.53202314.22 202562013.53202461314.22734,910,0002024630768,760,000 8. 3,134,929,00020246302,725,525,0005,937,754,75420246305,925,786,074 8. 9. 10. 50312 10. (b) 10. (c) 11. (a)3.89%5.10% (b)2025630 13. 202563020241231 14. (a)1.3%5.5% 15. 16. 202563020241231 17. 20211226.0202620213460.00202312312024630202462658.13202492657.482026122 562,489,0003,634,633,000 37,511,000242,387,000 4,000,00025,847,000 2024122590,622,0004,183,198,0002021342025630 17. 18. 20195272029613202563038,379,834 20254288,560,9902025429202542823.934%33%33% 18. 202542818.677 2025428 23.254.573346.06%-47.81%1.5%2.72%-2.79% 7 8 , 5 8 5 , 0 0 02 0 2 463