翰森制药2024年报

2457828436170757677798082156 11, 22 11, 22 3692 600,000,00040546 2 Maples Fund Services (Cayman) LimitedP.O. Box 1093, Boundary HallCricket SquareGrand Cayman, KY1-1102Cayman Islands P.O. Box 309, Ugland HouseGrand Cayman, KY1-1104Cayman Islands 287 1617 3 33191928 45 97927 www.hspharm.com 50037 1HS-10501NMPA2 1HS-10398NMPAA HS-20117PM1080ADC 1HS-10504NMPANSCLC HS-20137QX004N ®NDANMPAEGFR1921(L858R)NSCLC ®NDANMPAEGFR1921(L858R)NSCLC BTKi HS-10561LP-168 GSKB7-H3ADCGSK5764227HS-20093FDAES-SCLCEMA(PRIME)ES-SCLC ®B~CEGFRNSCLCAENEAS2(PFS)®NDANMPA®EGFR1921(L858R)NSCLC HS-20093NMPAES-SCLC ®®®®®®® ADCHS-20110NMPA GLP-1HS-10535 ESGMSCIESGAA(S&PGlobal)2025(CSA)ESG www.hspharm.com ESGMSCIESGAA ADCAI GSKGSKBD ®®®®®® ®®® ® ®EGFRTKIEGFR-TKIT790MNSCLCEGFR1921(L858R)NSCLCEGFR1921(L858R)NSCLC ®ASCOELCCWCLCCSCOEGFRNSCLCACHIEVENSCLCPOLESTARASCOWCLCFrontiers in Pharmacology ®CSCO2024®®EGFREMA ® ®TKI®TKI®MMRMR4.5Bcr-AblTKI® ®JohnGoldman(ESHCML)ESMO(ASH) ® ®CD19 BAQP4NMOSDCD19Viela Bio Inc.HorizonTherapeuticsplcNMPAAQP4NMOSD MITIGATEIgG4-RDFDAIgG4-RD III®IgG4-RDNMPA(BLA)NMPA ®(ECTRIMS)(AAN)®2021A ® ®GLP-1RAPEGGLP-1RA2®®(CDS)2024® ®DKDFrontiers in Endocrinology® GLP-1RADKDDiabetes, Metabolic Syndrome andObesity®DKDGLP-1RA MedCommIF:10.7®2 ® ®(NRTI)NMPA ®4896144®(TDF) ®(APASL)(EASL)(AASLD)Journal of Viral HepatitisJournal ofClinical and Translational Hepatology ®20222022®2024A®2024A2 ® ®EPO®CKDESA® ®EPOREPORESA(EPOR/CD131)®eClinicalMedicine1®1~3(rHuEPO)EPOR ®Journalof Translational Medicine Kidney InternationalReportsKidney Medicine(ISPOR)(ASNKidneyWeek)(ISN)(WCN)® ®2024®2024 ® ®®2019® EGFRHS-10504NSCLCGLP-1HS-105012CDH6ADC HS-20124CDH17ADC HS-20110 B7-H3ADC HS-20093GLP-1/GIPHS-20094TYK2HS-10374 ® ®NDANMPA EGFR1921(L858R)NSCLC EGFR1921(L858R)NSCLC ®E G F R1 921(L858R)NSCLC ®c-METHS-10241EGFR-TKIEGFRMETNSCLC HS-20093 HS-20093B7-H3ADCB7-H3(TOPOi)HS-20093PoC ASCOHS-20093ARTEMIS-002HS-20093WCLCHS-20093ES-SCLCARTEMIS-001HS-20093ES-SCLC HS-20093NMPAES-SCLCHS-20093NMPA HS-20094 HS-20094GLP-1/GIPGLP-1GIPHS-20094 (ADA)HS-20094aHS-200942 HS-10374 HS-10374TYK2HS-10374(EADV)(CDA)HS-10374HS-10374TYK2 HS-10506 HS-105062(OX2R)(ECNP)HS-10506PKHS-10506 HS-10383 HS-10383P2X3(RUCC)(APSR)IbHS-10383 HS-10370 HS-10370KRAS G12CAACRHS-10370HS-10370KRAS G12CNSCLC BD BD GSKGSKBDGSK HS-20117EGFR/c-METADC HS-201171+1EGFR/c-METEGFRc-MET HS-20137QX004N HS-20137HS-20137 JAMADermatologyQX004NQX004N BD HS-10561LP-168 HS-10561BTKiHS-10561NMPA ® ®(XPO1)Antengene Corporation (Hong Kong) Limited®(R/RMM)®B(R/R DLBCL) HS-10516 HS-10516NKT2152HIF-2αNikangTherapeuticsHS-10516HS-10516NMPAvon Hippel-Lindau(VHL) BD HS-20093 (GSK) HS-20093B7-H3ADCGSKGSKHS-20093GSK57642271.8515.25GSK1.85 GSKGSK5764227GSKGSK5764227FDAEMA(PRIME) HS-20089 (GSK) HS-20089B7-H4ADCGSKGSKHS-20089GSK5733584 GSKGSK5733584 HS-10535 GLP-1HS-105351.1219 (ESG) ESGESG ESGESGESG MSCIESGAA2024(CSA)20252024ESGHRoot2024 ESG 590,622,000 5% GMP 2,300,000232.615.663,000,0001,315,065D. 11,397,5901,300,000291,85014A.73(6)14A.95 ESG BD A. C1 C.2.1 B. B. 3.13 B. (1)(2)(3)(4)(5) C.2.1 B. B.2.2 B. BBAB AB B. 3.2915 B. B. 1717 2,300,0002361611,397,59012 89 B. B. (1)(2)(3) B. 60.8%39.2% B. C3 7 1,000,0013,500,0003,500,0016,000,0006,000,0017,000,000 C. C. 7074 D. ••(www.hspharm.com)•• D. 12.3 33191928 www.hspharm.com 41 7581 13.5314.2220.1033.63 727 (www.hspharm.com)(www.hkexnews.hk) 1617 1617 4 13 5,935,650,07028 590,622,000 MorganStanley&Co.International plc Citigroup Global MarketsLimited130,380,000 590,622,00099.10%5,378,000 3038 13,999,985,00014,095,522,000 38 30%30% C2 6169 13.51B(1) 3.13 33D2 8.10(2)(b)8.10(2)(c) StellarInfinitySunriseInvestment 3314A GSKGSK5764227HS-20093FDAB7-H3ADC 3.0519.05(2)62216 ®MITIGATEIgG4-RDNMPA(BLA)NMPA 1BTKi HS-10561NMPA HS-20093NMPA ®NMPAEGFR1921(L858R)NSCLC® ADCHS-20122NMPA HS-20108NMPA KRAS G12D1HS-10529NMPAKRASG12D HS-20093NMPA XV(i)XV78(ii)352(iii)C3 (1)5,935,650,070 (2)StellarInfinityStellar InfinitySunriseInvestmentSunriseInvestmentHarmoniaHoldingHarmonia HoldingSunriseTrustSunriseTrustSunriseTrustXVStellarInfinity (3)StellarInfinity1,246,2002,554,100 (4)1,387,050852,850 (1)Sunrise InvestmentHarmonia HoldingHarmonia HoldingSunrise TrustSunriseTrustSunriseTrustXVHarmoniaHoldingSunrise Investment XVXV78352 XVXV23336 (1)5,935,650,070 (2)StellarInfinitySunriseInvestmentSunriseInvestmentSunriseTrustHarmoniaHoldingSunrise InvestmentHarmoniaHoldingStellarInfinity (3)Cantrust(Far East)LimitedJQCInternational LimitedApexMedical920,000,000XVCantrust (Far East) LimitedJQC International Limited XV23336 27 8.08(1)(d)16.21% D. 1. 2. (i) (ii) 3. 114,118,3842% 52,290,59446,172,474 0.192% 46,781,5840.788% 4. 121% 5. (i)(ii)(i)(ii)(iii)(iv)(v) 6. 7. 8. 9. 10. 25,688,6200.433% 10. (1)(2)(3)(4)(5)2716.847.(6)17.23(7)1,300,000291,85014A.73(6)14A.95 (i)120.1%(ii)1% 11.