翰森制药2023年报

2578920334955606162646567136 1HS-10390A ®®®®EGFR1921(L858R)NSCLC20214(AQP4)NMOSD2022 1HS-10506 1HS-20117PM1080 NiKangTherapeutics1HS-10516NKT2152 2 TiumBio1HS-10518TU2670 1®CKDESA SCYNEXISibrexafungerptabletsHS-10366 AntengeneCorporation(Hong Kong)Limited(selinexor)® 1HS-20105 Keros Therapeutics1HS-20106KER-050 GSKGlaxoSmithKlineIntellectualProperty(No.4)LimitedGSKHS-20089HS-20089B7-H4(ADC)I (ABSSSI) 1HS-10511(HCM) GSKGSKHS-20093HS-20093B7-H3ADCIII ®® MSCIESGAA(S&PGlobal)2023ESG1% www.hspharm.com/ 3692 600,000,00040546 Maples Fund Services (Cayman) LimitedPO Box 1093, Boundary HallCricket SquareGrand Cayman, KY1-1102Cayman Islands PO Box 309, Ugland HouseGrand Cayman, KY1-1104Cayman Islands 287201210 1617 3485 45 97927 www.hspharm.com 50037 ESGMSCI ESGAACSA692024 2023-2025 BD EGFR-TKIEGFR1921(L858R)NSCLCEGFR-TKIT790MNSCLC EGFRNSCLCIIINSCLC(mPFS)19.3NSCLCCNS(CNSPFS)29.0LBA) IIIcMETHS-10241IIIEGFR-TKIEGFRMETNSCLC I2023EGFRMHRAEMA Bcr-Abl TKIBcr-AblTKI 2019 GLP-1(CDS)22020 (HBV) III14474LBAIII48Aliment PharmacolTherapeutics96Journal of Clinical and Translational Hepatology 20222022I VielaBioHorizonTherapeutics plcHorizon Therapeutics plcAmgenCD19 BAQP4NMOSDFDA VielaBioNMOSDAmgenIgG4(IgG4-RD)(gMG)2021A 1ESACKDESA EPO(EPOR)EPORESAsEPORCD131III(TheLancet)eClinicalMedicineEPOESAs HS-10241MET-(TKI)NSCLCIJTO Clinical and Research ReportsHS-10241IbEGFR-TKIEGFRMETNSCLCIIIEGFR TKIEGFRMETNSCLC HS-10365(RET)114IRETNSCLCHS-10365RETNSCLC HS-20089B7-H4LBAII(TNBC)II HS-20093B7-H3(TOPOi)B7-H3HS-20093ARTEMIS-001I(NCT05276609)2023HS-20093III HS-20094-1(GLP-1)(GIP)III2 BD BD BDGSKBD GSKGSKHS-20089HS-20093HS-20089HS-20093(ADC)HS-20089HS-20093 BD (selinexor)CD38/ HS-20117 HS-10516NiKangTherapeutics HS-10518TiumBio HS-20106KerosTherapeutics (ESG) ESGESG ESGESGESGESG (ESG) MSCIESGAACSAS&P2024TheAssetESGHRoot 2023 ESG 5% GMP ComputershareHong KongTrusteesLimited11,000,0001102.2914.9610,028,0009,614,700D. 20,304,40052,290,5941,300,000600,00014A.73(6)14A.95 A. C1 C.2.1 B. B. 3.13 (1) (2) B. (3)(4)(5) C.2.1 B.2.2 B. / ABBAB AB B. 3.2915 B. 17/17 11,000,00011068520,304,40012 B. B. (1)(2)(3) B. 62.4%37.6% B. *2023 C3 5 500,000500,0001,000,0001,000,0011,500,0001,500,000 C. C. 5559 D. ••(www.hspharm.com)•• D. 12.3 3485 www.hspharm.com (i)A1(ii) 4/1 6066 14.2257.0721.29 819 (www.hspharm.com)(www.hkexnews.hk) 1617 1617 7 13 5,933,350,07028 / MorganStanley&Co.International plc Citigroup Global MarketsLimited130,380,000 3139 14,095,522,00013,931,541,000 39 30%30% 13.91C2 4954 13.51B(1) 3.13 34D2 8.10(2)(b)8.10(2)(c) StellarInfinitySunriseInvestment 3414A 1HS-105091HS-105012 1HS-10398A 590,622,00099.10%5,378,000 HS-20117PM1080 1HS-10504 2,300,000 / XV(i)XV78(ii)352(iii)C3/ / (1)5,933,350,070 (2)StellarInfinityStellar InfinitySunriseInvestmentSunriseInvestmentSunrise TrustSunrise TrustThe Sunrise Trust (Sunrise TrustSunrise TrustSunriseTrustXVStellar Infinity (3)Stellar Infinity408,1002,092,200 (4)955,5001,177,500 2. (1)SunriseInvestmentSunriseTrustSunrise TrustSunriseTrustSunriseTrustSunriseTrustXVSunriseTrust / 2. XVXV78352/ / XVXV23336 (1)5,933,350,070 (2)StellarInfinitySunriseInvestmentSunriseInvestmentSunriseTrustSunrise InvestmentSunrise TrustStellar Infinity (3)Cantrust (Far East) LimitedJQC International LimitedApex Medical950,000,000XVCantrust (Far East) LimitedJQC International Limited / XV23336 8.08(1)(d)16.21% D. 1. 2. (i) (ii) 3. 114,118,3842% 69,652,85452,290,594 0.34% 53,279,9940.90% 4. 121% 5. (I)(II)(i)(ii)(iii)(iv)(v) 6. 7. 8. 9. 10. 35,405,0000.597% 10. (1)(2)29(3)(4)(5)(6)(7)(8)14.56(9)1,300,000600,00014A.73(6)14A.95 (i)120.1%(ii)1% 11. 12. 3 Tetrahedron/Tetrahedron Letters 189668082185002352CYOU60301207 600533688300603059 // LakeForest GraduateSchool BDBDMedical College of Wisconsin VMR Ernst & Young27/F, One Taikoo Place979 King’s RoadQuarry Bay, Hong Kong Tel曢婘: +852 2846 9888Faxₚ䜆: +852 2868 4432ey.com ⭰㰟㛪姯⸒Ṳ⋀㈧榀㸖毩歁㵳勘䙮怺979噆⤑⏋✱ᷧ⺎27㧺 60135 2 0 2 31 23 13,209,633,00010% 2.431835 •••••• 1. Maples Corporate Services Limited, PO Box 309, Ugland House, Grand Cayman, KY1-1104, CaymanIslands Stellar Infinity Company Ltd.Harmonia holding Investing(PTC)LimitedStellar Infinity Company Ltd.Harmonia Holding Investing(PTC)Limited VIE 2 2.1 (a) (b) (c) 2.1 2.2 171281212 (a)122 2.2 (b)8 (c)1212 (d)12 2.3 10283161120201,4120221,4771212 1202411220251134202020225 2.4 2.4 2.4 2.4 (a)(i)(ii)(iii) (b) (i)(ii)(iii)(iv)(v)(vi)(a)(vii)(a)(i)(viii) 2.4 20-3053-103-54 2.4 10 2.4 (a) 503-12 (b) 2.4 (c) 12 2.4 15 2.4 ••(a)(b) 2.4 1212 90 12 2.4 112 2 3 2.4 2.4 2.4 •• •• 2.4 15 2.4 (a) 15 (b) 2.4 (b) (i)(ii) 2.4 29 2.4 2.4 3. 2023123120221231202312312,457,444,00020221,146,087,00026 3. 18 20231231684,706,00020221231412,579,0002036 29 4. 90%8 4. 10% 5. 5. 1231 20231231699,844,