
2457182930313234353760 3692 600,000,00040546 P.O. Box 309, Ugland HouseGrand Cayman, KY1-1104Cayman Islands 287201210 45 3485 97927 www.hspharm.com 50037 Maples Fund Services (Cayman) LimitedP.O. Box 1093, Boundary HallCricket SquareGrand Cayman, KY1-1102Cayman Islands 1617 ••••• 1HS-10390A ®®®®EGFR1921(L858R)NSCLC4(AQP4)NMOSD 1HS-10506 1HS-20117PM1080 NiKangTherapeutics1HS-10516NKT2152 2 TiumBio1HS-10518TU2670 1®CKDESA (S&PGlobal)ESG1% www.hspharm.com/ BD EGFR1921(L858R)NSCLC4(AQP4)NMOSDCKDESA EGFR-TKIEGFR1921(L858R)NSCLCEGFR–TKIT790MNSCLC EGFRNSCLCASCONSCLC(mPFS)19.3ASCONSCLCCNS(CNS PFS)29.0 EQRxEQRxEQRxMHRAEMA ICSCO20238EGFR Bcr-AblTKICMLBcr-AblTKICSCOCML (HBV)2022CSCO2022I GLP-1(CDS)22020 2019 Viela BioHorizon Therapeutics plcCD19BAQP4NMOSDFDAVielaBioNMOSD2021A 1ESACKDCKDCKDESA EPO(EPOR)EPORESAsEPORCD131ESAsEPO CKDESA P O C( i )H S - 1 0 3 5 3(ii)HS-10365(iii)HS-10380(iv)HS-200942(v)HS-20093(vi)HS-10374 •HS-10365AACRIRETNSCLC•HS-20093B7-H3ASCOI•HS-10241MET-TKIEGFR-TKIMETASCOHS-10241IbHS-10241EGFR-TKIEGFRMETNSCLC 1CKDESA 1HS-10390A 1HS-10506 1HS-20117PM1080 NiKangTherapeutics1HS-10516NKT2152 TiumBio1HS-10518TU2670 BD BDPOC BD BD 1HS-20117PM1080 PM1080 NiKang Therapeutics 1HS-10516NKT2152 NiKang TherapeuticsNKT2152 TiumBio 1HS-10518TU2670 TiumBioTU2670 (ESG) ESGESGESG (ESG) CSA1%CSAMSCIESG A ESG 51% 18 BD GMP 11,000,0001102.292.6014.566,656,0006,242,700D. 20,304,40049,348,4541,300,000600,00014A.73(6)14A.95 XV(i)XV78(ii)352(iii) 1. (1)5,933,350,070 (2)StellarInfinity Company Ltd.StellarInfinityStellar InfinitySunriseInvestmentAdvisors LimitedSunriseInvestmentSunrise InvestmentHarmoniaHoldingInvesting(PTC)LimitedSunriseTrustSunrise TrustTheSunrise TrustSunriseTrustSunrise TrustSunrise TrustXVStellar Infinity Stellar Infinity408,1002,092,200 (4)955,5001,177,500 (1)SunriseInvestmentSunriseTrustSunrise TrustSunriseTrustSunriseTrustSunriseTrustXVSunriseTrustSunrise Investment XVXV78352 XVXV23336 (1)5,933,350,070 (2)Stellar InfinitySunrise InvestmentSunrise InvestmentSunrise TrustSunrise TrustSunrise InvestmentSunrise TrustStellar Infinity (3)ApexMedical Company Ltd.ApexMedicalApexMedicalCantrust(Far East)LimitedJQCInternationalLimitedApexMedical950,000,000XVCantrust(Far East)LimitedJQC International Limited XV23336 (i)(ii)D. 114,118,3842% 50,599,9940.85% 69,652,85450,599,994 (I)(II)(i)(ii)(iii)(iv)(v) 37,095,6000.63% 1. (1)(2)20(3)(4)(5)(6)(7)(8)14.56(9)1,300,000600,00014A.73(6)14A.95 (i)120.1%(ii)1% 13.51B(1) IbrexafungerpTabletsHS-10366SCYNEXIS,Inc.(Ibrexafungerp) EQRxEQRxMHRAEMA AntengeneCorporation(Hong Kong)Limited(selinexor)® C.2.1 C.2.1 C.2.1 3.21D.3 7.0751617 MorganStanley&Co.International plc Citigroup Global MarketsLimited130,380,000 30592023630343434 2410 34 2023831 2,3813,546(92,638)(185,914)(102,029)(16,680)166,532–3,567,676(5,694,345)(638,568)(92,841)(2,106,360)407,535156,21280,95842,0903,62046,57625,761 1515 1. 2.1 20236303420221231 2.2 20221231 179 1717171281212 2.3 III 202311202363097,881,000202363097,881,000 3. 90%8 10% 4. 5. 6. 16.5% 6. 25%200811 20142014201615%201720192020202215% 20172017201915%20202020202215% 20212021202315% 7. 20225.0020219.00 2023615.0020226109.00268,852,0002022630455,826,000 8. 5,923,743,16620225,916,956,923 9. 10. 503512 10. 12. 13. (a)1.20%4.32% (b)2023630 14. 202363020221231 4.10%5.34% 15. (a)3.20%5.90% 16. 17. 18. 20211226.0202620213460.0020241222026122 562,489,0003,634,633,000 37,511,000242,387,000 4,000,00025,847,000 18. 202212283,720,0004,000,000 19. (a)20234212019527RSU11,000,0002.6 2023831131313 20. 20195272029613 202342720,304,400202342714.5634%33%33% 20. 202342711.50 2023427 14.342.84346.15%-51.81%0%3.21%-3.29% Computershare Hong Kong Trustees Limited() 21. 2023630 22. 202363020221231 23. 24. 24. 2023630 583,577,000 24. 202363020221231 24. 24. 12320221231 25. 2023810AntengeneCorporation(Hong Kong)Limited(selinexor) MAA MHRA NiKang TherapeuticsNiKang Therapeutics Inc. NMOSD POC (R&D) TiumBioTiumBio Co., Ltd. FDA Viela BioViela Bio, Inc. % *