QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period endedJune 30,2025 OR For the transition period fromto Surrozen, Inc. (Exact Name of Registrant as Specified in its Charter) Delaware30-1374889( State or other jurisdiction ofincorporation or organization)(I.R.S. EmployerIdentification No.)171 Oyster Point Blvd,Suite 400,South San Francisco,California94080(Address of principal executive offices)(Zip Code)Registrant’s telephone number, including area code: (650)489-9000 Securities registered pursuant to Section 12(b) of the Act: Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject tosuch filing requirements for the past 90 days.Yes☒No☐ Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required tosubmit such files).Yes☒No☐ Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, smaller reporting company, oran emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerginggrowth company” in Rule 12b-2 of the Exchange Act. Large accelerated filer☐Non-accelerated filer☒Emerging growth company☒ Accelerated filer☐ Smaller reporting company☒ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying withany new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.☐ Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).Yes☐No☒ As of August 4, 2025, there were8,570,355shares of common stock, par value$0.0001 per share, issued and outstanding. Table of Contents PART I.FINANCIAL INFORMATIONItem 1.Financial Statements1Unaudited Condensed Consolidated Balance Sheetsas of June 30, 2025 and December 31, 20241Unaudited Condensed Consolidated Statements of Operationsfor the three and six months ended June 30,2025 and 20242Unaudited Condensed Consolidated Statements of Stockholders’ Equity (Deficit)for the three and sixmonths ended June 30, 2025 and 20243Unaudited Condensed Consolidated Statements of Cash Flows for the six months ended June 30, 2025 and20244Notes to Unaudited Condensed Consolidated Financial Statements5Item 2.Management’s Discussion and Analysis of Financial Condition and Results of Operations18Item 3.Quantitative and Qualitative Disclosures About Market Risk26Item 4.Controls and Procedures26 PART II.OTHER INFORMATIONItem 1.Legal Proceedings28Item 1A.Risk Factors28Item 2.Unregistered Sales of Equity Securities, Use of Proceeds and Issuer Purchases of Equity Securities72Item 3.Defaults Upon Senior Securities72Item 4.Mine Safety Disclosures72Item 5.Other Information72Item 6.Exhibits73Signatures74 CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS Some of the statements contained in this Quarterly Report on Form 10-Q for the three and six months ended June 30, 2025, or theQuarterly Report, constitute forward-looking statements within the meaning of the federal securities laws. Forward-lookingstatements relate to expectations, beliefs, projections, future plans and strategies, anticipated events or trends and similar expressionsconcerning matters that are not historical facts. These forward-looking statements include statements about future financial andoperating results of Surrozen; statements about the plans, strategies and objectives of management for future operations of Surrozen;and statements regarding future performance. In some cases, you can identify these forward-looking statements by the use ofterminology such as “believes,” “expects,” “potential,” “continues,” “may,” “will,” “should,” “could,” “seeks,” “approximately,”“plans,” “estimates,” “anticipates” or the negative version of these words or other comparable words or phrases. The forward-looking statements contained in this Quarterly Report reflect our current views about future events and are subject tonumerous known and unknown risks, uncertainties, assumptions and changes in circumstances that may cause its actual results todiffer significantly from those expressed in any forward-looking statement. There are no guarantees that the transactions and eventsdescribed will happen as described (or that they will happen at all). The following factors, among others, could cause actual resultsand future events to differ materially from those set forth or contemplated in the forward-looking stat