Surrozen Inc美股招股说明书(2025-04-24版)

Up to 1,091,981 Shares of Common Stock Up to 2,363,258 Shares of Common Stock Issuable Upon Exercise of Warrants This prospectus supplement updates, amends and supplements the prospectus contained in ourRegistration Statement on Form S-3, effective as of April 25, 2024 (Registration No. 333-278800) relating to the resale from time to time by the selling stockholders of: •Up to 1,091,981 shares of common stock;•Up to 40,000 shares of common stock issuable upon exercise of pre-funded warrants; •Up to 1,131,981 shares of common stock issuable upon exercise of Series A common stock warrants; •Up to 4,386,424 shares of common stock issuable upon exercise of Series C common stock warrants (which have been subsequently cancelled as described below); and (which have been subsequently cancelled as described below). stock warrants, Series B common stock warrants, Series C common stock warrants and Series D commonstock warrants from us pursuant to a securities purchase agreement, dated April 1, 2024. warrants had been exercised prior to cancellation; accordingly, the offering of an aggregate of 8,772,848shares of common stock issuable upon exercise of such warrants pursuant to the prospectus is herebyterminated.This prospectus supplement is being filed to update the information in the prospectus with the informationsummarized above and contained in our Current Report on Form 8-K filed with the Securities and ExchangeCommission on March 28, 2025. You should read this prospectus supplement, together with additionalinformation described under the headings “Incorporation of Certain Documents by Reference” and “WhereYou Can Find More Information” in the prospectus carefully before you invest in our securities. supplement is truthful or complete. Any representation to the contrary is a criminal offense.The date of this prospectus supplement is April 24, 2025.