严重眼部损伤和眼部刺激综合检测和评估方法指导文件（IATA），第三版

Series on Testing and Assessment Guidance Document on IntegratedApproaches to Testing and Assessment(IATA) for Serious Eye Damage and EyeIrritation, Third Edition Pleasecitethispublicationas: OECD (2024),Guidance Document on Integrated Approaches to Testing and Assessment (IATA) for Serious Eye Damageand Eye Irritation,Third edition,OECD Series onTesting and Assessment, OECD Publishing, Paris,https://doi.org/10.1787/cdb440be-en. © OECD 2024 Attribution 4.0 International (CC BY 4.0) This work is made available under the Creative Commons Attribution 4.0 International licence. By using this work, you acceptto be bound bythe terms of this licence(https://creativecommons.org/licenses/by/4.0/). Attribution–you must cite the work. Translations–you must cite the original work, identify changes to the original and add the following text:In the event of any discrepancy between the original work and thetranslation, only the text of original work should be considered valid. Adaptations–you must cite the original work and add the following text:This is an adaptation of an original work by the OECD. The opinions expressed and arguments employedin this adaptation should not be reported as representing the official views of the OECD or of its Member countries. for any claims of infringement. About the OECD TheOrganisation for Economic Co-operation and Development(OECD)is an intergovernmentalorganisation in whichrepresentatives of 38 countries in North and South America, Europe and the Asiaand Pacific region, as well as the European Union, meet to co-ordinate and harmonise policies, discussissues of mutual concern, and work together to respond to international problems. Most of the OECD’swork is carried out by more than 200 specialised committees and working groups composed of membercountrydelegates.Observers from several Partner countries and from interested internationalorganisations attend many of the OECD’s workshops and other meetings. Committees and working groupsare served by the OECD Secretariat, located in Paris, France, which is organised into directorates anddivisions. The Environment, Health and Safety Division publishes free-of-charge documents in twelve differentseries:Testing and Assessment;Good Laboratory Practice and Compliance Monitoring;Pesticides;Biocides;Risk Management;Harmonisation of Regulatory Oversight in Biotechnology;Safety ofNovel Foods and Feeds; Chemical Accidents; Pollutant Release and Transfer Registers; EmissionScenario Documents; Safety of Manufactured Nanomaterials;andAdverse Outcome Pathways.More information about the Environment, Health and Safety Programme and EHS publications is availableon the OECD’s World Wide Web site (https://www.oecd.org/en/topics/chemical-safety-and-biosafety.html). This publication was developed in the IOMC context. The contents do not necessarilyreflect the views or stated policies of individual IOMC Participating Organizations. The Inter-Organisation Programme for the Sound Management of Chemicals (IOMC)was established in 1995 following recommendations made by the 1992 UN Conferenceon Environment and Development to strengthen co-operation and increase internationalco-ordination in the field of chemical safety. The Participating Organisations are FAO,ILO,UNDP,UNEP,UNIDO,UNITAR,WHO,World Bank,Basel,Rotterdam andStockholm Conventions and OECD. The purpose of the IOMC is to promote co-ordinationof the policies and activities pursued by the Participating Organisations, jointly orseparately, to achieve the sound management of chemicals in relation to human healthand the environment. Foreword This document has two aims: First, it suggests an Integrated Approach on Testing and Assessment (IATA) for serious eye damage andeye irritation hazard identification, in view of replacing the "sequential testing strategy", which has originallybeen provided in the supplement to OECDTG 405 and which requires adaptation to technical progress. Second, the document provides key information characteristics of each of the individual informationsources comprising the IATA. Furthermore, it provides guidance on how and when to integrate existingand/or newly generated information for decision making,including decisions on the need for further testingor final decisions on classification and labelling regarding the potential eye hazard effects of test chemicals. This Guidance Document was originally approved by the 29th Meeting of the WNT in April 2017, updatedin 2018 to reflect revisions of Test Guidelines, in particular TG 438 and TG 492, and again in 2024 toinclude new and updated Test Guidelines 494, 496, 467, and 492B.In the latest update, the decision treefor IATA was updated toaccount for theavailability of TGs 467 and 492B, stand-alone methods that canpredict three UN GHS categories for eye hazards, along with other updates to reflect the latest status ofinformation sources available for IATA. This document is published under the responsibility of the Chemicals