关于使用综合测试和评估方法（IATA）进行生物累积的案例研究——第九个审查周期（2023年）

Series on Testing and AssessmentNo. 404 Case study on the Use of IntegratedApproaches for Testing and Assessment(IATA) for Bioaccumulation–Ninth ReviewCycle (2023) OECD (2024),Case study on the Use of Integrated Approaches for Testing and Assessment (IATA) for Bioaccumulation–NinthReviewCycle(2023),OECDSeriesonTestingandAssessment,No.404,OECDPublishing,Paris.https://doi.org/10.1787/8bc8ad6f-en. © OECD 2024 Attribution 4.0 International (CC BY 4.0) This work is made available under the Creative Commons Attribution 4.0 International licence. By using this work, you acceptto be bound by the terms of this licence (https://creativecommons.org/licenses/by/4.0/). Attribution–you must cite the work. Translations–you must cite the original work, identify changes to the original and add the following text:In the event of any discrepancy between the original work and thetranslation, only the text of original work should be considered valid. Adaptations–you must cite the original work and add the following text:This is an adaptation of an original work by the OECD. The opinions expressed and arguments employedin this adaptation should not be reported as representing the official views of the OECD or of its Member countries. Third-party material–the licence does not apply to third-party material in the work. If using such material, you are responsible for obtaining permission from the third party andfor any claims of infringement. Any dispute arising under this licence shall be settled by arbitration in accordance with the Permanent Court of Arbitration(PCA) Arbitration Rules 2012. The seat of arbitrationshall be Paris (France). The number of arbitrators shall be one. About the OECD TheOrganisation for Economic Co-operation and Development(OECD)is an intergovernmentalorganisation in whichrepresentatives of 38 countries in North and South America, Europe and the Asia andPacific region, as well as the European Union, meet to co-ordinate and harmonise policies, discuss issuesof mutual concern, and work together to respond to international problems. Most of the OECD’s work iscarried out by more than 200 specialised committees and working groups composed of member countrydelegates. Observers from several Partner countries and from interested international organisations attendmany of the OECD’s workshops and other meetings. Committees and working groups are served by theOECD Secretariat, located in Paris, France, which is organised into directorates and divisions. The Environment, Health and Safety Division publishes free-of-charge documents in twelve different series:Testingand Assessment;Good Laboratory Practice and Compliance Monitoring;Pesticides;Biocides;Risk Management;Harmonisation of Regulatory Oversight in Biotechnology;Safety ofNovel Foods and Feeds; Chemical Accidents; Pollutant Release and Transfer Registers; EmissionScenario Documents; Safety of Manufactured Nanomaterials;andAdverse Outcome Pathways.More information about the Environment, Health and Safety Programme and EHS publications is availableon the OECD’s World Wide Web site (https://www.oecd.org/en/topics/chemical-safety-and-biosafety.html). This publication was developed in the IOMC context. The contents do notnecessarilyreflect the views or stated policies of individual IOMC Participating Organizations. The Inter-Organisation Programme for the Sound Management of Chemicals (IOMC)was established in 1995 following recommendations made by the 1992 UN Conferenceon Environment and Development to strengthen co-operation and increase internationalco-ordination in the field of chemical safety. The Participating Organisations are FAO,ILO,UNDP,UNEP,UNIDO,UNITAR,WHO,World Bank,Basel,Rotterdam andStockholm Conventions and OECD. The purpose of the IOMC is to promote co-ordinationof the policies and activities pursued by the Participating Organisations, jointly orseparately, to achieve the sound management of chemicals in relation to human healthand the environment. Foreword OECD member countries have been making efforts to expand the use of alternative methods in assessingchemicals. The OECD has been developing guidance documents and tools for the use of alternativemethods such as (Q)SAR, chemical categories and Adverse Outcome Pathways (AOPs) as a part ofIntegrated Approaches for Testing and Assessment (IATA). There is a need for the investigation of thepractical applicability of these methods/tools for different aspects of regulatory decision-making, and to buildupon case studies and assessment experience across jurisdictions. The objective of the IATA Case Studies Project is to increase experience with the use of IATA by developingcase studies, which constitute examples of predictions that are fit for regulatory use. The aim is to createcommon understanding of using novel methodologies and the generation of considerations/guidancestemming from these case studies. This case study was developed by Health and Environmental Sciences Institute (HES