使用综合方法测试和评估农用化学品慢性毒性和致癌性的案例研究——第九个审查周期（2023年）

Serieson Testing and AssessmentNo.402 Case Study on the Use of IntegratedApproaches for Testing and Assessment(IATA)for Chronic Toxicity andCarcinogenicity of Agrichemicals withExemplar Case Studies NinthReview Cycle (2023) Pleasecitethispublicationas: OECD (2024),Case Study on the Use of Integrated Approaches for Testing and Assessment for Chronic Toxicity andCarcinogenicity of Agrichemicals withExemplar Case Studies–Ninth Review Cycle(2023), OECD Series onTesting andAssessment, No.402, OECD Publishing, Paris. © OECD 2024 Attribution 4.0 International (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/). Attribution–you must cite the work. Adaptations–you must cite the original work and add the following text:This is an adaptation of an original work by the OECD. The opinions expressed and arguments employedin this adaptation should not be reported as representing the official views of the OECD or of its Member countries. Third-party material–the licence does not apply to third-party material in the work. If using such material, you are responsible for obtaining permission from the third party andfor any claims of infringement. About the OECD TheOrganisation for Economic Co-operation and Development(OECD)is an intergovernmentalorganisation in which representatives of 38 countries in North and South America, Europe and the Asiaand Pacific region, as well as the EuropeanUnion, meet to co-ordinate and harmonise policies, discussissues of mutual concern, and work together to respond to international problems. Most of the OECD’swork is carried out by more than 200 specialised committees and working groups composed of membercountry delegates.Observers from several Partner countries and from interested internationalorganisations attend many of the OECD’s workshops and other meetings. Committees and working groupsare served by the OECD Secretariat, located in Paris, France, which is organised into directorates anddivisions. The Environment, Health and Safety Division publishes free-of-charge documents in twelve differentseries:Testing and Assessment;Good Laboratory Practice and Compliance Monitoring;Pesticides;Biocides;Risk Management;Harmonisation of Regulatory Oversight in Biotechnology;Safety ofNovel Foods and Feeds; Chemical Accidents; Pollutant Release and Transfer Registers; EmissionScenario Documents; Safety of Manufactured Nanomaterials;andAdverse Outcome Pathways.More information about the Environment, Health and Safety Programme and EHS publications is availableon the OECD’s World Wide Web site (https://www.oecd.org/en/topics/chemical-safety-and-biosafety.html). This publication was developed in the IOMC context. The contents do not necessarilyreflect the views or stated policies of individual IOMC Participating Organizations. The Inter-Organisation Programme for the Sound Management of Chemicals (IOMC)was established in 1995 following recommendations made by the 1992 UN Conferenceon Environment and Development to strengthen co-operation and increase internationalco-ordination in the field of chemical safety. The Participating Organisations are FAO,ILO,UNDP,UNEP,UNIDO,UNITAR,WHO,World Bank,Basel,Rotterdam andStockholm Conventionsand OECD. The purpose of the IOMC is to promote co-ordinationof the policies and activities pursued by the Participating Organisations, jointly orseparately, to achieve the sound management of chemicals in relation to human healthand the environment. Foreword OECD member countries have been making efforts to expand the use of alternative methods in assessingchemicals. The OECD has been developing guidance documents and tools for the use of alternativemethods such as (Q)SAR, chemical categories and Adverse Outcome Pathways (AOPs) as a part ofIntegrated Approaches for Testing and Assessment (IATA). There is a need for the investigation of thepractical applicability of these methods/tools for different aspects of regulatory decision-making, and tobuild upon case studies and assessment experience across jurisdictions. The objective of the IATA Case Studies Project is to increase experience with the use of IATA bydeveloping case studies, which constitute examples of predictions that are fit for regulatory use. The aimisto create common understanding of using novel methodologies and the generation ofconsiderations/guidance stemming from these case studies. This case study was developed bytheInternational Council on Animal Protection in OECD Programmes(ICAPO) submitted to the 2023 review cycle of the IATA Case Studies Project.This case study wasreviewed by the project team. The Working Party on Hazard Assessment approved the case study at the8thWPHA meeting in June 2024. This case study is an illustrative example, and its publication does not translate into direct acceptance ofthe methodologies for regulatory purposes across OECD countries. In addition, this case study should notbe interpreted as official regulatory decisions made by the authoring member countr