中国阿尔茨海默病报告2024

中国阿尔茨海默病报告2024 王刚1*，齐金蕾2*，刘馨雅3*，任汝静4*，林绍慧5，胡以松6，李海霞4，谢心怡4，王金涛4，李建平4，朱怡康5，高梦伊5，杨竣杰5，王怡然5，井玉荣3，耿介立1，支楠1，曹雯炜1，徐群1，余小萍4，朱圆4，周滢7，王琳7，高超4，李彬寅4，陈生弟4，袁芳8，窦荣花9，刘晓云10，李雪娜11，尹雅芙12，常燕13，徐刚14，辛佳蔚15，钟燕婷2，李春波5，王颖3，周脉耕2，陈晓春15，代表中国阿尔茨海默病报告编写组 [1上海交通大学医学院附属仁济医院，上海200120；2中国疾病预防控制中心慢性非传染性疾病预防控制中心，北京100050；3复旦大学公共卫生学院，上海200032；4上海交通大学医学院附属瑞金医院，上海200025；5上海交通大学医学院附属精神卫生中心，上海200030；6中国人民大学中国调查与数据中心，北京100872；7上海交通大学医学院护理学院，上海200025；8山东大学附属齐鲁医院（青岛院区），山东青岛266071；9河北沧州中西医结合医院，河北沧州061001；10河北医科大学第一医院，河北石家庄050023；11中国医科大学附属第一医院，辽宁沈阳110001；12上海交通大学医学院附属新华医院，上海200092；13中国人民解放军总医院，北京100853；14上海交通大学医学院公共卫生学院，上海200025；15福建医科大学附属协和医院，福建福州350001] [摘要]随着我国经济的持续增长和社会人口结构的显著变化，老龄化社会所带来的老年性疾病问题愈发受到关注，尤其是以阿尔茨海默病（Alzheimer’s disease，AD）为代表的神经退行性疾病，已成为严重影响老年人群健康和生活质量的重大挑战。近年来，中国的AD发病率、患病率和死亡率均呈现上升趋势，对患者家庭、社会乃至整个医疗保健系统构成了沉重的经济负担。为了积极应对这一挑战，响应国家“健康中国行动”的号召，推动医疗模式从疾病治疗向健康维护转变，由上海交通大学医学院附属仁济医院牵头，组织中国疾病预防控制中心慢性非传染性疾病预防控制中心、复旦大学公共卫生学院、上海市精神卫生中心、上海交通大学医学院附属瑞金医院、福建医科大学等多家权威机构的专家学者，共同编撰了《中国阿尔茨海默病报告2024》。该报告在2021、2022、2023年系列版本的基础上，进一步更新了中国AD的流行病学数据，深入分析了疾病经济负担的最新情况，并全面评估了我国AD诊疗服务的现状和公共卫生资源的配置。《中国阿尔茨海默病报告2024》的发布，不仅体现了我国在AD研究和防控方面的进步和努力，也彰显了全社会对老年健康问题的高度重视。本报告将为AD的预防、诊断和治疗提供科学的技术指导和有力的数据支持，为政府和相关部门制定针对性的卫生政策和干预措施提供专业依据，同时也为促进国内外在该领域的学术交流与合作搭建平台。期待通过这份报告的传播和应用，不仅能为专业人员提供参考和借鉴，也可以进一步提高公众对AD的认识，促进社会各界共同推动我国老年健康事业的发展，为实现“健康老龄化”而持续赋能。 关键词：阿尔茨海默病；流行病学；诊断；治疗；公共卫生资源 中图分类号：R749.1+6；R446.1文献标志码：A文章编号：1671‑2870（2024）03‑0219‑38DOI:10.16150/j.1671‑2870.2024.03.001 China Alzheimer Report2024 WANG Gang1*,QI Jinlei2*,LIU Xinya3*,REN Rujing4*,LIN Shaohui5,HU Yisong6,LI Haixia4,XIE Xinyi4,WANG Jintao4,LIJianping4,ZHU Yikang5,GAO Mengyi5,YANG Junjie5,WANG Yiran5,JING Yurong3,GENG Jieli1,ZHI Nan1,CAO Wenwei1, XU Qun1,YU Xiaoping4,ZHU Yuan4,ZHOU Ying7,WANG Lin7,GAO Chao4,LI Binyin4,CHEN Shengdi4,YUAN Fang8,DOU Ronghua9,LIU Xiaoyun10,LI Xuena11,YIN Yafu12,CHANG Yan13,XU Gang14,XIN Jiawei15,ZHONG Yanting,LIChunbo5,WANG Ying3,ZHOU Maigeng2,CHEN Xiaochun15,representing the China Alzheimer's Disease Report Writing Group1.Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai200120,China;2.Chronic Non⁃communi⁃cable Disease Prevention and Control Center,Chinese Center for Disease Control and Prevention,Beijing100050,China;3.School of Public Health,Fudan University,Shanghai200032,China;4.Ruijin Hospital,Shanghai Jiao Tong UniversitySchool of Medicine,Shanghai200025,China;5.Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai200030,China;6.National Survey Research Center at Renmin University of China,Beijing100872,China;7.Nursing College,Shanghai Jiao Tong University School of Medicine,Shanghai200025,China;8.Qilu Hospital(QingdaoBranch),Shandong University,Qingdao Shandong266071,China;9.Hebei Province Cangzhou Integrated Hospital of Tradi⁃tional Chinese and Western Medicine,Cangzhou,Hebei061001,China;10.The First Hospital of Hebei Medical University,Shijiazhuang Hebei050023,China;11.The First Affiliated Hospital of China Medical University,Shenyang,Liaoning110001,China;12.Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai200092,China;13.ChinesePeople's Liberation Army General Hospital,Beijing100853,China;14.School of Public Health,Shanghai Jiao Tong UniversitySchool of Medicine,Shanghai200025,China;15.Concord Hospital of the Fujian Medical University,Fuzhou,Fujian350001,China. [Abstract]With the sustained growth of economy and significant changes in social demographics,the issue of el‑derly‑related diseases has increasingly drawn attention particularly.Alzheimer's disease(AD),as a representative disease ofneurodegenerative diseases has become a major challenge,affecting the health and quality of life among the elderly popu‑lation severely.In recent years,the incidence,prevalence,and mortality rate of AD increase in China,imposing substantialeconomic burdens on families,society,and the entire healthcare system.To proactively address this challenge and respondto the national 'Healthy China Action' initiative,leading experts from Renji Hospital,Shanghai Jiao Tong University Schoolof Medicine,and Chinese Center for Disease Control and Prevention Chronic Non‑communicable Disease Control Center,Fudan University School of Public Health,Shanghai Mental Health Center,Ruijin Hospital,Shanghai Jiao Tong UniversitySchool of Medicine,Fujian Medical University,and other authoritative institutions,have jointly authored the 'China Al‑zheimer Disease Report2024'.Building upon previous editions of2021,2022,and2023,this report updates epidemiologi‑cal data on AD in China,thoroughly analyzes the latest economic burdens of the disease,and comprehensively evaluatesthe current status of AD diagnosis and treatment services,as well as the allocation of public health resources in our country.The release of the 'China Alzheimer Disease Report2024' not only reflects China's progress and efforts in AD research andprevention,but also underscores the social heightened concern for elderly health issues.It aims to provide scientific andtechnical