三叶草生物-B2024中期报告

2197 2024 24672143444547495176 Donna Marie AMBROSINORalf Leo CLEMENS PO Box 309, Ugland HouseGrand Cayman, KY1-1104Cayman Islands Jeffrey FARROWThomas LEGGETT 7581901 Thomas LEGGETTJeffrey FARROW 33191901 Maples Fund Services (Cayman) LimitedPO Box 1093, Boundary HallCricket SquareGrand CaymanKY1-1102Cayman Islands Thomas LEGGETT 183171712-1716 2197 www.cloverbiopharma.com 202111 5 15323203-3207 97927 202312 311,095.5265.720246 30829.8 20246 30AdimFlu-S10.1 20236 302,510.82,443.720246 3067.1CEPI2023 20236 3022.515.820246 306.7AdimFlu-S 20236 30109.567.462%20246 3042.1 20236 30385.6287.375%20246 3098.3SCB-2019CpG 1018CMC 20236 301,330.91,328.420246 302.52023 20246 3095.120236 30650.62023CEPI (RSV) •F(PreF)RSV•202312F(Pre-F)RSV(SCB-1019)ITrimer-Tag•20244618-5960-85I AdimFlu-S (QIS) •20232AdimFlu-S •20247AdimFlu-S SCB-219M •SCB-219MTPOFc(CIT) •SCB-219M(BD)2024CITIb •202212(EUA) •20247 15 SCB-2019CpG 1018RSVSCB-1019Trimer-TagTrimer-TagTrimer-TagICTrimer-Tag RSV PreFSCB-101918-59≥60IRSV2023RSVSCB-1019RSV≥602-52024720239AdimFlu-S RSV Trimer-TagF(PreF)RSV 202312ISCB-1019 20246SCB-1019I48SCB-101960-85418-59 •RSV-A28SCB-1019RSV-A(GMT)7,906 IU/mL1,078 IU/mL•RSV-B28SCB-1019RSV-B(GMT)46,674 IU/mL12,185 IU/mL•RSV PreF1,2,3SCB-1019RSV-ARSV-BRSV-ARSV-B1,4,5RSV-A/B PreF•SCB-1019PreFØV •SCB-1019SCB-1019(AE)•(SAE)(AESI)AE•4mRNA5RSVSCB-1019 SCB-1019 I2024RSVSCB-1019 AdimFlu-S 20232AdimFlu-S 20247AdimFlu-SAdimFlu-SRSV SCB-219M SCB-219MTPOFc(CIT)TPOSCB-219M(ADA) •202312SCB-219MI•SCB-219M(BD)2024CITIb •20247 15 •202212(EUA)(BLA) 20246 30124 GMP(DML) RSVSCB-1019 (1)(2) 2023Trimer-TagIPreF RSV2024I 20246 30AdimFlu-S10.1 2022202320232024202420242024202320246 30 20236 302,510.82,443.720246 3067.1CEPI2,494.12023 20246 20236 3022.515.820246 306.7AdimFlu-S (i)(ii)(iii)(iv) 20236 30109.567.462%20246 3042.1 (i)(ii)(iii)(iv)CDMO(v) 20236 30385.6287.375%20246 3098.3(i) SCB-2019CpG 1018CMCCDMO(ii) 20236 301,330.91,328.420246 302.520231,236.7 (i)(ii) 20236 3011.77.420246 304.3 20246 3095.120236 30650.6 20246 30202312 311,095.5265.7829.8 20246 301,614.3829.873.6696.714.2 20246 302,073.21,589.1181.277.912.1212.9 20246 30212.92.4%6.4805% 20246 3020246 30 20246 30 100%20246 30 20246 3013.9202312 3116.12.2 20246 30347.2 20246 3032320246 3094.120246 30 20214 1520219 26D. 20246 30XV352 (1)20246 30(2)(3)20213 16(4)20246 30(5)20246 30(6)20246 301,297,048,929 20246 30 20246 30XV23336 (1)AUT-XXI Hong Kong Holdings LimitedAUT-XXIAUT-XXI Holdings LimitedAUT HoldingAUT HoldingHH IMV Holdings, L.P.HH IMVHH IMVHillhouse Fund IV, L.P.Hillhouse FundHillhouseInvestment Management, Ltd.Hillhouse InvestmentAUT HoldingHH IMVHillhouse FundHillhouse InvestmentAUT-XXI JNRY V Holdings LimitedJNRYHillhouse InvestmentHillhouse InvestmentJNRY (2)99%42%58% 20246 3030,660,00070% (3)IIIIIIIVIVIV (4)20246 301,297,048,929 20246 30336 18 13.51B (1) 20244 20241 20244 Thomas LEGGETT20245Stoke Therapeutics, Inc.STOK Ralf Leo CLEMENS20241ArcturusTherapeuticsARCT Ralf Leo CLEMENS20243Icosavax, Inc.ICVX Ralf Leo CLEMENS20245Valenva SEVALNVLAValenva SE Ralf Leo CLEMENS20245 Ralf Leo CLEMENS20245ILiAD Biotechnologies 20243 27(i)202312 31(ii) 20246 20 3.21C1Thomas LeggettJeffrey FarrowThomas LeggettJeffrey Farrow3.10(2)3.21 20246 30 13.2013.2113.22 20214 15 (a) (b) (i)(ii) (iii) (iv) (c) 25,947,096 (d) (e) (f) 20246 30 (1)(2)20246 301,297,048,929 1,848,8170.14% 20214 1520219 2620244 2 (a) (b) (i)(ii)(iii)(iv) (c) 77,350,0005.96% (d) (e) (a)(b) (5) (f) 10202141520219 267 (g) 20246 305415,557,01420246 30 (1)20246 301,297,048,929(2)25%361/48(3)(4)25%25%(5)20234 1(6)(25%)20236 15(7)(i)1/4825%75%(ii)1/48(8)(i)(25%)(ii)(25%)202312 1(9)(25%)20234 1(75%)(10) (11)20223 3120225 1220227 19202212 1520234 112024426.993.113.623.51.650.4120223 31202251220227 19202212 1520234 1120244 26.92.823.643.241.820.400.4420232.430 (12)202212 1620231 31(13)20235 302023(14)(15)(25%)(16)(17)(25%)20244 2(75%)(18)106,00020244 2 33,400,60627,876,704 20219 26 (a) (b) (i)(ii)(iii)(iv) (c) 1,158,114,723115,811,47210%115,751,136(i)(ii)8.92% (d) 121%12 (e) (f) (i)(ii)(iii) (g) (h) 20219 2610710 (i) 20246 3013335,401,79120246 30 (1)20223 3120225 1220227 19202212 1520234 112024426.993.113.623.51.650.4120223 31202251220227 19202212 1520234 1120244 24.151.242.231.600.990.2220232.430(2)10(3)20246 301,297,048,929(4)20225 520225(5)(6)(25%)20236 15(7)20234 1(8)(i)1/4825%75%(ii)1/48(9)(i)(25%)(ii)(25%)202312 1(10)(25%)20234 1(75%)(11) (12)20235 302023(13)(14)(25%)20244 2(75%) 74,170,84180,349,345 0.76% 202111 51,884.31,549.0 20238 2320238 2220238 22415.2 20246 301,398.290.3%20238 22 20246 30 1. 2. 202212 6202212 13202212 6128,000,000202212 13500.5449.0 20238 2320238 2220238 2269.4 20246 30416.692.8%2023822 20246 30 1.2. 20246 30 • • ••••Trimer-TagGenHunter••••Trimer-Tag•CRO• 1. 201810 31PO Box 309, UglandHouse, Grand Cayman, KY1-1104, Cayman Islands 202111