友芝友生物-B2024 中期报告

2 7 9 10 21 38 39 40 42 43 44 16 Zhou Pengfei 3485 2024430 H 183171712-1716 88173121209 Dai Weiguo2024730 666 13381 Zhou Pengfei •8835 Zhou PengfeiDai Weiguo20247302024829 835 2496 71810-11 21T21-3 www.yzybio.com 724-4 2010(BsAb)Y-BODY®Check-Body Nano-Ybody® (MA)(MPE)BsAbTBsAbM701(TME)BsAbY101DY332M701Y101DM701EpCAMTCD3BsAbM701MAMPEY101DPD-L1TGF-βBsAb (1)(2)20249Y101DI(3)Y400CMS R&D*IND MonoComboEpCAMCD33PD-L11TGF-ββVEGFANG22wAMDDME M701 M701BsAbEpCAMTCD3M701MAMPE •MAM701MAIIIM701MA 20242M701MAIIICDE 20243M701MAIII 20246M701MAII2024ASCO •MPEM701MPEIb/IIIb24IbM701NSCLCMPE 20243II 20249(ESMO)2024Ib Y101D Y101DPD-L1TGF-βBsAbY101D1PD-1)PD-L1TGF-β20249Y101DI •Y101DIb/II20236Ib/IIIbII202310II2025Ib/II2028Y101D •HCCY101D(HCC)Ib/II Y332 Y332VEGFTGF-βBsAbY332VEGFTGF-β202310Y332I Y400 Y400VEGFANG2BsAb Y400Y400CMSR&D20234Y400INDY400IIY400 Y225 Y225EmicizumabY22550L 18A.08(3)M701Y101D Y332Y225Y400 CMO/CDMO 1,4005002005020-24M701Y3322024M701Y400 CMO/CDMOM701CMO/CDMO M701M701300(CSO)20M701M7012024 2024(i)M701MAIIIM701MPEIb/IIII(ii)Y101DIb/IIII(iii)Y332I(iv)M701 (i)(ii)(iii) 6.92.14.83.935516.62.81.8 (i)(ii) 2.21.40.82.21.3 (i)(ii)(iii)(iv)(v)CROSMO CMO/CDMO (i)(ii)(iii)(iv)(v)(vi) 13.18.34.8(i)3.3(ii)0.6 13.52023 2.01.40.6 78.486.68.2 202463020231231196.7161.9 2024630210.9161.943.10.75.42024630170.179.550.339.50.50.4 58.272.378.4(i)13.0(ii)7.9(iii)3.2(iv)2.0(i)4.7(ii)2.2 4.544.25.72.2 27.849.080.050.0 79.540.0 2024630119.580.039.52023123189.52024630119.52024630120.5 20246300.6202312310.6 100%2023123170.6%2024630161.6%2024 2024630 20246305.58.00.5 20246301149024 1728,413,11822,602,9135,810,205H14.66% 2024630 2024630XV(i)XV78(ii)352(iii) (1)202463082,380,386111,468,814H(2)ZhouPengfei201863020201026202362(i)(ii)(3)50%30%1,342,600H(4)50.76%ZhouPengfei49.95%Zhou Pengfei16,792,707(5)60.00%1,426,827H1,611,513(6)60.00%6,695,271H3,447,526(7)H 2024630XV233365% (1)202463082,380,386111,468,814H(2)ZhouPengfei20201026202362(i)(ii)(3)50%30%1,342,600H(4)(5)50.76%ZhouPengfei49.95%(6)54.06%45.94%100.00%51,241,785H(7)(i)72.38%(ii)(iii)(i)6,695,271H3,447,526(ii)3,700,872H(iii)1,426,827H1,611,513(8)(i)CDHGrowth FundSoonerStar Limited(ii)CDH R-III Parallel HoldingsCompany LimitedCDH Growth Fund(iii)CDH R-III Parallel Holdings Company LimitedCDH GP HoldingsCompany Limited43%CDH GP Holdings Company LimitedCDH Investment Management CompanyLimitedCDH 2018 VGC Investment Fund, L.P.57%CDH Management Company Limited100%(iv)CDH Investment Management Company LimitedCDH Management Company LimitedCDH Griffin(v)CDH GriffinCentral Oak Company Limited33.2%CentralOak Company LimitedSooner Star LimitedCDH Growth FundCDH R-III Parallel Holdings Company Limited CDH GP Holdings Company Limited CDH InvestmentManagement Company LimitedCDH 2018 VGC Investment Fund, L.P.CDH Management Company LimitedCDH GriffinCentral Oak Company Limited7,916,510H(9)(i)(ii)31.13%(iii)60%40% 7,628,713H (10)(i)(ii)60%40%40%7,196,835H (11)98.59%7,000,000 (12)2,686,000H5,600,000 (13)50.91%49.09%57.00%43.00%35.00%90.00%54.61%1,400,000 (14)H XV233365% 2024H 2024H 2024627172024H 2024H19,384,800HH10.0%1,938,400HH1.0% 2024H (a)(b)(c) 2024H(10)2024H2024H2024H2024H 2024H (a)2024H (b) (i) (1)(2)(3) (ii) (i)H19,384,800H10.0%(ii)H1,938,400H1.0% 121% 2024H 120.1% (12)(12) (a)(b)(c)(d)(e)12 (10) (a)H(b)(5)H(c)H 124.4202463058.3 C1 C.2.1 C.2.1ZhouPengfei 2024430Dai Weiguo2024730202411 20231231 20231231 13.51B(1) 2024827 3.21 •2410 Zhou Pengfei 2024916 39562024630343434 24102410 34 •2024829 20246 30 20246 30 20246 30 20246 30 1. 20107820221132023925666 (BsAb) 2024630 2. 3434 3. 202463020231231 202411 161177 4. 202463020236302024630 5. 6. 7. 8. 9. 20246301,016,744,00020231231903,871,000202463039,036,0002023123134,356,000 10. 2024202363020242023630 11. 2023630 12. 202363023,00023,000 826,0002023630795,000 2722,00020236301,211,000629,00020236301,211,000 576,000583,0007,000 13. 15. 15. 090 16. 80,000,000202363020,000,0003.4%3.5% 50,000,000202363011,000,00030,000,00020246305,530,0007,969,000470,000 17. 202312312024630 18. 20227 5,000,0001,000,000202342720221020236 202446,000,00039,495,00035,115,0006,752,00040,843,0005,728,00020246305,728,000 19. 202312312024630 20. RSRS ESOP ESOP2015816,500,0000.86.36120218ESOP3,285,000 20246 30 20. RSRS ESOPRSRS202188,375,0004,840,0003,285,000 RS1.586.361 RS20218 2024630550,0001Zhou Pengfei 202426.36275,00025% 2024630RS108,0002023630 20. 20218202012A11,418,000RSRS RS6.361.00 RS20218 2024630575,000 202426.36575,00025% 2024630RS223,0002023630 21. 22. 202463020231231 23. (a) (b) 202463020231231 23. (c)