友芝友生物-B2025 中期报告

2025中 期 報 告 2467183536383940 16 33191915 Zhou Pengfei2025625 H 2025625 183171712-1716 20256252025625 666 13381 Zhou Pengfei •8835 Zhou Pengfei 835 71810-11 488 724-4 www.yzybio.com 2010(BsAb)Y-BODY®Check-Body Nano-Ybody® (MA)(MPE)BsAbTBsAbM701(TME)BsAbY101DY332M701Y101DM701EpCAMTCD3BsAbM701MAMPEY101DPD-L1TGF-βBsAb (1)M701 (2)Y400CMSR&DCMS R&DY400 (3) MonoComboEpCAMCD33PD-L11TGF-β-βVEGFANG22nAMDDME M701 M701BsAbEpCAMTCD3M701MAMPE 202410M7012024107 20253M701 20254M701 20255M701 •MAM701MAIIIM701MA 20257M701MAIII312 •MPEM701MPEIb/IIIb24IbM701NSCLCMPE 20257M701MPEII93% M701NSCLCMPEII(ESMO)202510(poster) MAIIIMPEII Y101D Y101DPD-L1TGF-βBsAbY101D1PD-1)PD-L1TGF-β20249Y101DI •Y101DIb/II20236Ib/IIIbII2025202510CSR Y332 Y332VEGFTGF-βBsAbY332VEGFTGF-β202310Y332I 20252Y332I18 Y332 Y400 Y400Y400CMSR&DY4001VEGFA/ANG2VEGFAANG2VEGFY400IIY400III Y225 Y225EmicizumabY225500LGMP500L 20251Y225 2025Y225 IND Y232 Y232TL1A×XBsAb 18A.08(3)M701Y101D Y332Y225Y232Y400 CMO/CDMO 1,4005002005020-24M701Y33220251-7Y22536 CMO/CDMOM701Y225CMO/CDMO 2025(i)M701M701MPEINDM701MAMPEIIIII(ii)Y225IND(iii)Y101DIb/IIIIY332I(iv)M701 (i)(ii) 20256304.7 202563032.5 (i)(ii)(iii) 4.82.97.74.435517.22.81.4 (i)(ii) 0.52.21.71.7 (i)(ii)(iii)(iv)(v)CROSMO CMO/CDMO 60.270.310.1(i)5(ii)4.3(iii)0.8 (i)(ii)(iii)(iv)(v)(vi) 12.113.1 2.42.00.4 58.878.419.6 202563020241231126.3166.2 2025630195.3166.224.11.33.72025630212.5101.856.239.514.20.50.3 12.258.258.8(i)6.8(ii)2.1(iii)2.4(i)60.3(ii)1.3(iii)0.5 0.34.50.50.2 26.927.869.940.4 2025630 2025630156.476.480.020241231126.92025630156.42025630150.0 20256300.3202412310.5 100%20241231249.8%2025630-317.8%2025 2025630 20256305.17.70.4 20256301068224 2024H20245292025527 1728,413,11822,602,9135,810,205H14.66% 2025630 2025630XV(i)XV78(ii)352(iii) (1)202563082,380,386111,468,814H (2)ZhouPengfei201863020201026202362(i)(ii) (3)50%30%1,342,600H (4)50.76%ZhouPengfei49.95%Zhou Pengfei16,792,707 (5)(i)72.38%(ii)(iii)(i)6,695,271H3,447,526(ii)3,700,872H(iii)1,426,827H1,611,513 (6)H 2025630XV233365% (1)202563082,380,386111,468,814H(2)ZhouPengfei20201026202362(i)(ii)(3)50%30%1,342,600H(4)(5)50.76%ZhouPengfei49.95%(6)54.06%45.94%100.00%51,241,785H(7)(i)72.38%(ii)(iii)(i)6,695,271H3,447,526(ii)3,700,872H(iii)1,426,827H1,611,513(8)(i)60.00%(ii)60.00%(i)6,695,271H3,447,526(ii)1,426,827H1,611,513(9)(i)CDHGrowth FundSoonerStar Limited(ii)CDH R-III Parallel HoldingsCompany LimitedCDH Growth Fund(iii) CDH R-III Parallel Holdings Company LimitedCDH GP HoldingsCompany Limited43%CDH GP Holdings Company LimitedCDH Investment Management CompanyLimitedCDH 2018 VGC Investment Fund, L.P.57%CDH Management Company Limited100%(iv) CDH Investment Management Company LimitedCDH Management Company LimitedCDH Griffin(v) CDH GriffinCentral Oak Company Limited33.2%CentralOak Company LimitedSooner Star LimitedCDH Growth FundCDH R-III Parallel Holdings Company Limited CDH GP Holdings Company Limited CDH InvestmentManagement Company LimitedCDH 2018 VGC Investment Fund, L.P.CDH Management Company LimitedCDH GriffinCentral Oak Company Limited7,916,510H (10)(i)(ii)31.13%(iii)60%40%7,626,513H (11)(i)(ii)60%40%40%7,196,835H (12)98.59%7,000,000 (13)2,686,000H5,600,000 (14)50.91%49.09%57.00%43.00%35.00%90.00%54.61%1,400,000 (15)H XV233365% 2024H 2024H 2024627172024H 2025112024HH19,384,800H1,938,400H20255272024H3,550,0003,550,000H20256302024HH15,834,800H1,938,400H2025630H3,050,0002025850 2024H (a) (b) (c) 2024H(10)2024H2024H2024H2024H 2024H 2024H (a)2024H (b) (i) (1)(2)(3) (ii) (i)H19,384,800H10.0%(ii)H1,938,400H1.0% 121% 2024H 120.1% (12)(12) (a)(b)(c)(d)(e)12 (10) 2025630H (1)H500,000202584(2)20262120272120282120292125%20255272025527(3)(i)H4.23(ii)H4.226(iii) HH2025526H4.23 22 124.42025630 (1)M701202410(2)Y101D20251(3)20247 C1 C.2.1 C.2.1ZhouPengfei 20256252025625 13.51B(1) 3.21 Zhou Pengfei 2025916 20256 30 20256 30 20256 30 20256 30 1. 20107820221132023925666 (BsAb) 2025630 2. 3434 2025630202563017,157,00027,445,000202563058,834,000569,221,0002025630 (a)2025630166,182,000 (b) 20256 30 3. 202563020241231 202511 21 4. 202410 4. 20256304,717,0002024630 • • 20256 30 4. 5. 5. 10% 6. 7. 8. 9. 10. 20256301,275,146,000202412311,150,530,000202563035,823,0002024123128,860,000 20256 30 11. 202563022 20246302024630 12. 2024630 13. 15,00020246307,00015,00020246307,000 118,0002024630826,000 2025630275,00020241231454,000331,00020241231510,000 14. 16. 20161231202412312025630 090 16. 17. 69,900,000202463080,000,0002.5%3.4%20246303.4%3.5% 60,000,000202463030,000,0009,900,0002024630 18. 20256 30 19. 202412312025630 20. 20227 5,000,0001,000,00020234272023620221020236 202446,000,00039,495,00035,115,0006,752,00040,843,0005,728,000202465,728,000202576,752,000 21. 202412312025630 22. RSRS ESOP ESOP2015816,500,0000.86.36120218ESOP3,285,000 ESOPRSRS202188,375,0004,840,0003,285,000 RS1.586.361 R