Absci Corp美股招股说明书(2026-06-24版)

13,495,277 Shares of Common Stock Absci Corporation We are offering directly to investors 13,495,277 shares of our common stock, par value $0.0001, or the common stock, at a price per share of $7.41, ofwhich 5,398,111 shares, for an aggregate offering price of $40million, have been allocated for purchase by Eli Lilly and Company. Our common stock is listed on The Nasdaq Global Select Market under the symbol “ABSI.” On June 23, 2026, the last reported sale price of shares ofour common stock on The Nasdaq Global Select Market was $7.41 per share. We are a “smaller reporting company” as defined under the federal securities laws and, as such, we have elected to comply with certain reducedreporting requirements for this prospectus supplement and may elect to do so in future filings. Investing in our securities involves a high degree of risk. See the section entitled “RiskFactors” beginning on page S-7of this prospectus supplement and elsewhere in this prospectus supplement and the accompanying base prospectus for adiscussion of information that should be considered in connection with an investment in our securities. Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed uponthe adequacy or accuracy of this prospectus supplement. Any representation to the contrary is a criminal offense. PerShareTotalOffering Price$7.4100$100,000,002.5700Underwriting Discount and Commissions(1)$0.4446$6,000,000.1542Proceeds, Before Expenses, to Us$6.9654$94,000,002.4158 (1)See the section titled “Underwriting” beginning on page S-18 of this prospectus supplement for additional information. The underwriters expect to deliver the shares to purchasers on or about June25,2026. Book-Running Managers Jefferies GuggenheimSecurities The date of this prospectus supplement is June 24, 2026. Table of Contents TABLE OF CONTENTS Prospectus Supplement ABOUT THIS PROSPECTUS SUPPLEMENTMARKET, INDUSTRY AND OTHER DATAPROSPECTUS SUPPLEMENT SUMMARYTHE OFFERINGRISK FACTORSCAUTIONARY STATEMENT REGARDING FORWARD-LOOKING STATEMENTSUSE OF PROCEEDSDILUTIONMATERIAL U.S. FEDERAL INCOME TAX CONSEQUENCES TO NON-U.S. HOLDERSUNDERWRITERSLEGAL MATTERSEXPERTSWHERE YOU CAN FIND MORE INFORMATIONINCORPORATION OF CERTAIN INFORMATION BY REFERENCE Prospectus ABOUT THIS PROSPECTUSWHERE YOU CAN FIND MORE INFORMATIONINCORPORATION OF CERTAIN INFORMATION BY REFERENCESPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTSABOUT THE COMPANY RISK FACTORS USE OF PROCEEDSDIVIDEND POLICYGENERAL DESCRIPTION OF SECURITIESDESCRIPTION OF CAPITAL STOCKDESCRIPTION OF DEBT SECURITIESDESCRIPTION OF WARRANTSDESCRIPTION OF UNITSPLAN OF DISTRIBUTIONLEGAL MATTERS EXPERTS Neither we nor the underwriters have authorized anyone to provide any information or to make any representations other than those contained orincorporated by reference in this prospectus supplement or the accompanying base prospectus. Neither we nor the underwriters takes any responsibilityfor, or provides any assurance as to the reliability of, any other information that others may give you. You should assume that the information appearingor incorporated by reference in this prospectus supplement, the accompanying prospectus or any free writing prospectus prepared by us is accurate onlyas of their respective dates or on the date or dates which are specified in such documents, and that any information in documents that we haveincorporated by reference is accurate only as of the date of such document incorporated by reference. Our business, financial condition, liquidity, resultsof operations and prospects may have changed since those dates. Neither we nor the underwriters are making an offer of these securities in any state orjurisdiction where the offer is not permitted. Table of Contents ABOUT THIS PROSPECTUS SUPPLEMENT This prospectus supplement and the accompanying base prospectus are part of a registration statement on Form S-3 (RegistrationNo.333-289541) that we filed with the Securities and Exchange Commission, or the SEC, using a “shelf” registration process. The accompanying baseprospectus provides you with a general description of Absci Corporation and the securities that may be offered. Each time we sell securities under theregistration statement through an underwriter, dealer or agent, a prospectus supplement will be provided that contains specific information about theterms of that offering. A prospectus supplement may also add, update or change information contained in the accompanying base prospectus. This prospectus supplement provides specific details regarding this offering of shares of common stock, including the purchase price per share. Tothe extent there is a conflict between the information contained in this prospectus supplement and the accompanying base prospectus, you should rely onthe information in this prospectus supplement. This prospectus supplement, the accompanying base prospectus, and the