居里 2025年度报告

Securities registered pursuant to Section12(g) of the Act: None Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.YesNoIndicate by check mark if the registrant is not required to file reports pursuant to Section13 or Section15(d) of the Act.YesNo Indicate by check mark whether the registrant: (1)has filed all reports required to be filed by Section13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2)has been subject to such filing requirements for the past 90days.YesNoIndicate by check mark whether the registrant has submitted electronically, every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).YesNoIndicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth Large accelerated filer☐Accelerated filerNon-accelerated filer☒Smaller reporting company☒Emerging growth company☐ If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revisedfinancial accounting standards provided pursuant to Section 13(a) of the Exchange Act.Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectiveness of its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registered public accounting firm that prepared orissued its audit report.If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of the registrant included in the filing reflect the correction of an error to previously issued financial statements.☐Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-based compensation received by any of Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act).Yes☐NoThe aggregate market value of the registrant’s common stock held by non-affiliates of the registrant (without admitting that any person whose shares are not included in such calculation is an affiliate) based on the last reported sale price of the common stock on June30, 2025 was approximately $24.8 million. As of March20, 2026, there were39,978,693 shares of the registrant’s common stock outstanding. DOCUMENTS INCORPORATED BY REFERENCESpecified portions of the registrant’s proxy statement for the 2026 annual meeting of stockholders, which the registrants intends to file with the Commission not later than 120 days after the close of the Registrant’s fiscal year ended December 31, 2025 pursuant to Regulation 14A, have been incorporated by reference in Items10-14 of Part III ofthis Annual Report on Form 10-K. CURIS, INC.TABLE OF CONTENTSForm 10-KPART IITEM 1.BUSINESS6ITEM 1A.RISK FACTORS41ITEM 1B.UNRESOLVED STAFF COMMENTS82ITEM 1C.CYBERSECURITY82ITEM 2.PROPERTIES83ITEM 3.LEGAL PROCEEDINGS83ITEM 4.MINE SAFETY DISCLOSURES83PART IIITEM 5.MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUERPURCHASES OF EQUITY SECURITIES83ITEM 6.[RESERVED]83ITEM 7.MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OFOPERATIONS83ITEM7A.QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK94ITEM 8.FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA94ITEM 9.CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING AND FINANCIALDISCLOSURE119ITEM 9A.CONTROLS AND PROCEDURES119ITEM 9B.OTHER INFORMATION119ITEM 9C.DISCLOSURE REGARDING FOREIGN JURISDICTIONS THAT PREVENT INSPECTIONS119PART IIIITEM 10.DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE120ITEM 11.EXECUTIVE COMPENSATION120ITEM 12.SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATEDSTOCKHOLDER MATTERS120ITEM 13.CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS, AND DIRECTOR INDEPENDENCE120ITEM 14.PRINCIPAL ACCOUNTANT FEES AND SERVICES120PART IVITEM 15.EXHIBITS AND FINANCIAL STATEMENT SCHEDULES121ITEM 16.FORM 10-K SUMMARY126SIGNATURES126 PART I Cautionary Note Regarding Forward-Looking Statements and Industry DataThis Annual Report on Form 10-K contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995, which involve risks and uncertainties. All statements other than statements of historical fact contained in this AnnualReport are statements that could be deemed forward-looking statements, including without limitation any statements with respect to theplans, strategies and objectives of management for future operati