Creative Medical Technology Holdings Inc 2025年度报告

FORM 10-K (Mark One) ☒ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year endedDecember 31, 2025 TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from __________ to __________ Commission File Number: 000-53500 CREATIVE MEDICAL TECHNOLOGY HOLDINGS, INC.(Exact name of Registrant as specified in its charter) 87-0622284(I.R.S. Employer Nevada(State or other jurisdiction of incorporation or organization) 85012(Zip Code) 211 E Osborn Road, Phoenix, AZ(Address of principal executive offices) Issuer’s telephone number, including area code:(480) 399-2822 Securities registered pursuant to Section 12(b) of the Act: Name of each exchange on whichregistered Common Stock, par value $0.001 pershare TheNASDAQStock Market LLC CELZ Securities registered pursuant to Section 12(g) of the Act: None Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes☐No☒ Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or 15(d) of the Act. Yes☐No☒ Indicate by check mark whether the registrant (1) has filed all reports required to be filed by section 13 or 15(d) of the SecuritiesExchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports),and (2) has been subject to such filing requirements for the past 90 days. Yes☒No☐ Indicate by check mark whether the registrant has submitted electronically, every Interactive Data File required to be submittedpursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that theregistrant was required to submit such files). Yes☒No☐ Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smallerreporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smallerreporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act. Large accelerated filerNon-accelerated Filer Accelerated filerSmaller reporting companyEmerging growth company If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period forcomplying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act☐ Indicate by check mark whether the registrant has filed a report on and attestation to its management’s assessment of the effectivenessof its internal control over financial reporting under Section 404(b) of the Sarbanes-Oxley Act (15 U.S.C. 7262(b)) by the registeredpublic accounting firm that prepared or issued its audit report.☐ If securities are registered pursuant to Section 12(b) of the Act, indicate by check mark whether the financial statements of theregistrant included in the filing reflect the correction of an error to previously issued financial statements.☐ Indicate by check mark whether any of those error corrections are restatements that required a recovery analysis of incentive-basedcompensation received by any of the registrant’s executive officers during the relevant recovery period pursuant to §240.10D-1(b).☐ Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Act). Yes☐No☒ As of June 30, 2025, the aggregate market value of the registrant’s common stock held by non-affiliates was $4,633,334 based on theclosing price on the NASDAQmarket of such common stock on such date. As of March 20, 2026, there were 3,696,668 shares of the registrant’s common stock outstanding. DOCUMENTS INCORPORATED BY REFERENCE Portions of the registrant’s definitive proxy statement for the registrant’s 2025 Annual Meeting of Stockholders which will be filedwith the Commission no later than 120 days after the registrant’s fiscal year ended December 31, 2025, are incorporated by referenceinto Part III of this report. DISCLOSURE REGARDING FORWARD-LOOKING STATEMENTS The information contained in this Annual Report on Form 10-K contains certain forward-looking statements. All statements other thanstatements of historical facts contained or incorporated by reference in this Annual Report, including statements regarding our futurefinancial position, business strategy and plans and objectives of management for future operations, are forward-looking statements.The words “anticipate,” “believe,” “estimate,” “will,” “may,” “future,” “plan,” “intend” and “expect” and similar expressions generallyidentify forward-looking statements. These forward-looking statements are not guarantees and are subject to known and unknownrisks, uncertainties and assumptions that may cause our actual results, levels of activity, performance, or achievements to be materiallydifferent