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(Mark One)☒QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934For the Quarterly Period EndedSeptember 30,2025OR☐TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934Commission File Number001-37906 ORGANOGENESIS HOLDINGS INC. (Exact Name of Registrant as Specified in Its Charter) 98-1329150(I.R.S. EmployerIdentification No.) Delaware(State or Other Jurisdiction ofIncorporation or Organization) (781)575-0775(Registrant’s Telephone Number, Including Area Code) Not Applicable(Former name, former address and former fiscal year, if changed since last report) Securities registered pursuant to Section 12(b) of the Act: Trading Symbol(s)ORGO Class A Common Stock, $0.0001 par value Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 duringthe preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for thepast 90 days.Yes☒No☐ Indicate by check mark whether the registrant has submitted electronically every Interactive Data File required to be submitted pursuant to Rule 405 ofRegulation S-T (§ 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).Yes☒No☐ Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or anemerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” inRule 12b-2 of the Exchange Act. Large accelerated filer☐Non-accelerated filer☐ Smaller reporting company☐ Emerging growth company☐If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act☐ Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act). Yes☐No☒ The number of shares of the registrant’s Class A common stock outstanding as of October 30, 2025was126,912,142. Organogenesis Holdings Inc.Quarterly Report on Form 10-QFor the Quarterly Period Ended September 30, 2025 Table of Contents PART I. FINANCIAL INFORMATIONItem 1. Unaudited Condensed ConsolidatedFinancial StatementsCondensed Consolidated Balance SheetsCondensed Consolidated Statements of Operations and Comprehensive Income (Loss)Condensed Consolidated Statements ofRedeemable Convertible Preferred Stock andStockholders’ EquityCondensed Consolidated Statements of Cash FlowsNotes to Condensed Consolidated Financial StatementsItem 2.Management’s Discussion and Analysis of Financial Condition and Results of Operations21Item 3.Quantitative and Qualitative Disclosures About Market Risk31Item 4.Controls and Procedures31 Item 1.Legal ProceedingsItem 1ARisk FactorsItem 2.Unregistered Sales of Equity Securities and Use of ProceedsItem 3.Defaults Upon Senior SecuritiesItem 4.Mine Safety DisclosuresItem 5.Other InformationItem 6.Exhibits CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS This Quarterly Report on Form 10-Q (this “Form 10-Q”) contains forward-looking statements. These statements may relateto, but are not limited to, expectations of our future results of operations, business strategies and operations, financing plans,potential growth opportunities, clinical development and commercialization of our product candidates, potential marketopportunities and the effects of competition, as well as assumptions relating to the foregoing. Forward-looking statements areinherently subject to risks and uncertainties, some of which cannot be predicted or quantified. These risks and other factors include,but are not limited to, those listed under “Risk Factors.” In some cases, you can identify forward-looking statements byterminology such as “may,” “will,” “should,” “could,” “expect,” “plan,” “anticipate,” “believe,” “estimate,” “predict,” “intend,”“potential,” “might,” “would,” “continue” or the negative of these terms or other comparable terminology. These forward-lookingstatements are based on our management’s current expectations, estimates, forecasts and projections about our business and theindustry in which we operate and our management’s beliefs and assumptions. These forward-looking statements are not guaranteesof future performance or development and involve known and unknown risks, uncertainties and other factors that are in some casesbeyond our control. As a result, any or all of our forward-looking statements in this Form 10-Q may turn out to be inaccurate.Factors that may cause actual results to differ materially from current expectations include, among other things, those listed unde