博安生物2025中期报告

: 6955 2025 2013T-cellEngagerADC T 20256 5 20256 5 39 39 FCGHKFCG 33191918 H 183171712–1716 9 100020118 97927 6955 www.boan-bio.com Bank of AmericaCitibank N.A., Singapore Branch 1. 20256 30393.420246 30362.930.58.4%®®®20246 3015.9%385.3 2. 20256 30110.828.2%20246 3022.1% 3. 20256 30282.620246 30 4. 20256 30159.820246 30134.225.619.1% 5. 20256 3058.6202463027.2 T-cell EngagerADC T 2025 2025 20248.4%393.415.9%385.3®®®3,112®20258®®BLA20256®®2570,000100,0001,000 ®DTP2025160mg120mg®®®®®2025 BA9101BLA20247BA1104III5BA2101BA1106BA1301BA1302 BA1202I/IIBA11062025AACRBA1106BA110420256 BA6101BA1102IIIBA1104FDABPD2bFDABLAPKICCSIIIIIII20253BA1302FDAsqNSCLCODD20256BA1302FDA 20256 302542025935043 9,000L2,000L202562025 ®20256(BA9101) 20255MSCI ®BA1101VEGF® 20214®6 •20255® •BLA ®BA610160mgRANKG2® 202211® •20255 •IIIFDAEMAPMDAFDAEMAPMDAIIIBA6101BLA® ®BA1102120mgRANKG2® 202451≥45kg® •20252BA1102IIIJournal of Bone Oncology •20255 •IIIFDAEMA PMDAFDAEMA PMDAIIIBA1102BLA® ®BA51011 (GLP-1)® •20254BA5101Journal of Diabetes •20258®®BLA BA9101® (nAMD)(DME)(RVO)(DR)(mCNV)(ROP)1477BA910120247BLA BA11041(PD-1)PD-1PD-L1PD-L2T® 202310BA1104IIIIII •20253FDA2bFDABLAPKICCS, IIIFDAIIII I/II BA21014IL-4RIgG4 IL-4IL-13Th2IgETh2BA2101COPD2BA2101BA210141IBA21012023BA2101I20241BA2101IIBA2101COPD BA1106IL-2CD25 BA1106CD25T(Treg)TTregCD252IL-2RTregCD25TregTCD25CD25TTeffCD25TregTeffCD25IL-2T BA1106BA1106CD25TregCD25TeffIL-2Teff 2023BA1106II •20254I2025AACR31BA1106(i) BA110631BA11061(ii) BA1106PDTregTeffTregTeff(iii) BA11061.2mg/kgSAEBA1106SAETreg(iv) BA1106PK •20256BA1106BA1104 BA1301Claudin 18.2ADC BA1301Claudin 18.2Claudin 18.2 2023BA1301II BA1301FDAODD BA1302CD228ADC CD228BA1302MMAECD228 BA1302MMAEADCBA1302 20247BA1302CD228ADC •20253FDAsqNSCLCODD •20256FDA BA1304B7-H3EGFRADC 1+1BA1304ADCEGFREGFRB7-H3ADCCEGFRB7-H3on-target off-tumor60 mg/kgBA1304(Exatecan)BA1304B7-H3EGFRB7-H3EGFRB7-H3EGFRB7-H3EGFR • PR201PD-1/IL-2 PD-1PD1-2IL-2IL-2IL-2PR201PD-1/PD-L1 • PR203TL1AIL23p19 (IBD)(PS)(PSA)PR203TL1ABA-huMab®1+1FcPR203PR203First/Best-in-class • T-cell EngagerADC CMCCMC CMC 20256 30254 5043 (Nature)(Cell Discovery)Antibody Therapeutics(Cancer Communications)20 20253BIOCHINATOP10020258CMC2025TOP101 QPQP84,4742,000L9,000L20256 30393 ®®®® 15.9%385.320246 30332.5®® 20256 301913,112 2025560mg120mg®®20258®®®BLA 2023®20251BA6101BA110220256®2570,0001,000®DTP BA910120241BA2101COPD 2024BA6101BA110220256BA9101 2024BA-HIEXcell®BA-HIEXcell® 2024EMS DataManagerQC-Sample ManagerEBRAI 20256 30393.420.5A 20258®®®BLA202420795.891.4820508.531.68GLP-12024GLP-163.762024®52.5BA9101BLA2025BA9101®BA9101 202520252026BA6101BA1102BLA2025®BA1104®BA1104III BA1106CD25I2025AACRBA1106PD-12025BA1301(Claudin18.2 ADC)II20252025(ESMO)BA1302(CD228 ADC)I2025INDPR203TL1A/IL23PR201PD-1/IL-2BA1304EGFR/B7H3ADC 20256 30393.420246 30362.930.58.4%®®®20246 3015.9%385.3 20256 30110.828.2%202463022.1% 20256 30282.620246 30 20256 302.620246 3036.133.5 20246 3024.320256 3023.2 20256 30159.820246 30134.225.619.1% 20256 3058.620246 3027.2 20256 3019.520246 3012.66.954.8% 20256 30 20256 3020.520246 3061.7 2025 20256 30660.0202412 31198.9461.1231.8%20256 30547.3202412 31307.6202412 311.4720256 301.6120256 20256 30801.3202412 31678.9122.4 419.8381.52025630 20256 30202412 3141.3%39.4%20256 207.4202412 31217.3 20256 30 20256 30 20256 30 20256 30268.0 20256 30 20256 3071420246 3077720256 3061.620246 3086.4 20256 305% 20248 20248 726,655,600202484.97%9.50202482024826,655,60020247 30H9.79020247 31202487 250.689.4020248 20256 20256 1138,400,00020256202566.69%2025610.42202562025638,400,00020256 3H12.1002025620256 420256 1120258 142025620256(a)50%198.15(i) BA1106CD25BA1301 (Claudin18.2 ADC)BA1302 (CD228 ADC)(ii) BA1304EGFR/B7H3ADCPR201PD-1/IL-2(iii)(b)20%79.26(c)30%118.20(X)(Y)(Z) 395.610.3020256 20258 1448,000,00020258202587.71%2025816.42202582025820258 720258 14 20256 3020246 30 13.51B (1)2024 (1)20256 5(2)20256 5(3)20256 5(4)(5)20256 5 13.51B (1) C1 20256 30 C.2.1 C.2.1 20256 30 C32025630 20256 3020256 30 20256 30 241020256 30 20256 30XVXV78352C3 (i) 1.4,720,0006,800,000820,000 2.1,800,0001,730,0001,000,0001,090,000 3.2,480,0003,330,0003,000,0001,590,000 20256 30XV(i)352(ii) 20256 30XV23336 1.Luye HKLuye HKLuye HK 2.LuYe Investment33.47%LuYe InvestmentLuye Life SciencesLuYe InternationalLuye HoldingsLuye Life SciencesNelumbo70%NelumboGinkgoGinkgoShoreaLuYe InvestmentLuYeInternationalLuye Holdings Luye Life Sciences Nelumbo Ginkgo Shorea 3.Jingu Ruida No.18 Fund TrustJingu RuidaJingu RuidaJingu Ruida 4.21,415,54811,268,48814,954,632 20256 30XV23336 ࡋ؍㫵嬴㍳з⥽۱௚࢔每欧ࢅਸ਼छଳ 垹ןՎⵐ▲ ڇ㶣 Tel曢婘: +852 2846 9888Faxₚ䜆: +852 2868 4432ey.com Ernst & Young27/F, One Taikoo Place979 King’s RoadQuarry Bay, Hong Kong 314820256 30343434 2410 34 20258 27 1. 20256 3034202412 31 2. 202412 31 21 21 3. 4. 5. 6. 7. 20256 3020246 30 8. 574,333,6942024509,278,0