金斯瑞生物科技2025中期报告

(Incorporated in the Cayman Islands with limited liability)Stock code: 1548 235724434546485052 公司概況 (i)(ii) Probio Technology LimitedProbio CaymanCDMO(iii) Bestzyme Biotech Corporation2025630 10020256305,769 1002025 CDMO (cilta-cel)(MM)TCAR-T ESG John Quelch John Quelch Alphonse GaldesJohn QuelchRoss Grossman Alphonse Galdes Ross Grossman 1191904 ESG ʮ̡༟ࣘ 183171712–1716 97927 www.genscript.comwww.probiocdmo.comwww.bestzyme.comwww.legendbiotech.com 4th Floor, Harbour Place103 South Church Street, George TownP.O. Box 10240, Grand Cayman KY1-1002Cayman Islands 860 Centennial AvenuePiscatawayNJ 08854U.S. 1548 24840 Harneys Services (Cayman) Limited4th Floor, Harbour Place103 South Church StreetGeorge TownP.O. Box 10240, Grand Cayman KY1-1002Cayman Islands •518.82024630285.281.9% •320.6133.5140.1% 178.029.2509.6% •24.5215.6193.72025 ৌਕࠅ࿜ (2)(i)(ii)(iii)(iv)(v)(vi)(vii)(viii) (3)(5836 管理層討論及分析 518.8285.281.9%320.6133.5140.1% 25.5175.1 (i)(ii)(iii)47.2%47.0%5.5% 247.6222.411.3%126.3119.95.3%53.9%51.0%47.846.4 ၍ଣᄴীሞʿʱؓ (i)(ii)(iii) 246.940.4511.1%181.65.914.7%73.6%149.618.9 GMP 28.326.18.4%11.411.03.6%42.2%40.4%0.62.3 (i)(ii) ESGESG 2023(UNGC)2025(PSCI)(SBTi)EcoVadisMSCI ESGAASustainalyticsESGESG GBS2025GBS20(Kaizen)GBSGBS 518.8285.281.9%(i)(ii) 133.5140.1%320.6133.0% 43.110.2%47.5(i)(ii)10.4% 52.719.7%63.1(i)(ii)24.7% 24.925.7%31.325.2% 2021818Probio CaymanProbio Cayman300,000,000Probio Cayman AA189,393,939Probio CaymanProbio CaymanProbio Cayman150.0Probio CaymanProbioCayman125.02025428AA14.4202151420216720218192021952025428202557 2023117Probio CaymanProbio Cayman319,998,370Probio Cayman CC224.0C202311720232102023421 ACA ၍ଣᄴীሞʿʱؓ 2025630C248.0AC13.8 202272Probio CaymanProbio Cayman57,314,000Probio Cayman BB37.3BB202276202274202276 B 202352637,609,0705.3250.035.210.4168%AA202352620235282023625 A 2025630B1.642.31.1A39.61.2 9.8149.0%24.4 24.5137.7178.0 202410222024101810 77.9 2025630943.920241231719.922.72024123117.9 2025630532.720241231577.6 20256302.0202412312.718.6%2024123118.1% ၍ଣᄴীሞʿʱؓ 1.038.3 20256303665.6%193.7 812 2025630 1.5%5.7%20256302025630 (i)(ii) ၍ଣᄴীሞʿʱؓ (a)2025630* * **AB 1414.0720256305.0% 1.36.9 2025630 ၍ଣᄴীሞʿʱؓ 2025630939.9131.32.25%2.60%350.849.0 2025630129.218.0LPR0.6%20257 202563020.72.91.95% 202563023.23.21.9% 2025630 202412312024 202563034.64.8129.218.020257 20256308.812.91.0 2025630226.631.7B202274Probio Cayman2022629202274 2025630 2025630 (i)(ii)GMPCGT(iii) 20253GMP2025(AAV)2026GMP(LVV)CGT(NME)3 (CD3)(VHH)TTCE(sdAbs)(mAbs)(BsAbs) IT 2025630 20191 2025630202412318.2 2025630532.0 501.3 500.4 (i) (ii) ၍ଣᄴীሞʿʱؓ 202525ESG 2025627213.8(i)(ii)(iii)PD-1PD-1PD-1/VEGFLM-299LM-299202411152025630 Scripting Possibilities202588 2002100230,000CGT 20256305,7699.5% 143.045.4% 其他資料 2025630XVXVXV78352C3 (1)2025630201980,000743,320320,701 (2)2025630Genscript CorporationGS Corp10.70%GS CorpGS Corp202561620232,394,935GS Corp4,253,415201732,563,800GS Corp4,553,3202025616202320255312024II20242,394,9355,918,130GS Corp4,253,41510,510,62415,000,000GS Corp26,640,06420252025 (3)201710122025630GS Corp20.36% (4)2025630201983,276634,0001,095,539 (5)2025630GS Corp4.15%GS CorpGS Corp (6)2008814GS CorpGS CorpGS Corp2025630799,999,1232015529GS CorpGS Corp22.66% 2025630201960,000228,630 (8)201710520172025630GS Corp8.06%20211221Ren-Shiu Foundation Inc.638,000Ren-ShiuFoundation Inc. (9)202563020195,480270,0009,449 (10)2025630John Quelch202121,905 (11)2025630Ross Grossman202121,905 (12)202563020193,824,584202129,9542,000,0001,099,459 (1)174,497,556202563047.27% (2)2025630369,141,409 (3)2025630174,904,728(i) 407,172GS Corp(ii) 174,497,556GS CorpGS Corp174,904,728 (4)753,406 (5)2025630174,904,728(i) 407,172GS Corp(ii) 174,497,556GS CorpGS Corp174,904,7282025630816 (6)2025630Fanny Wan4,2008,400 (7)2025630Ross Grossman3,738202052620203,348 2025630XV(i)352(ii) 2025630XV23336 Չ˼༟ࣘ (1)2025630GS Corp320242025201752020A52020L52022520235202454B10.70%20.36%2.58%3.28%3.33%22.76%0.43%3.99%3.72%3.72%1.85%0.29%8.66%4.15%8.06%1.05%1.07% (2)Huang LiliHuang Lili638,000 (3)201710122025630GS Corp20.36%GS Corp202563020242025GS Corp2.58%3.28%3.33% (4)20171052025630GS Corp8.06%GS Corp (5)201712172017201720201028Descendants’ Separate Trust FBO A2020ADescendants’ Separate Trust FBO L2020L202210312022202220231031202320232024103020242024 (6)2025630Huang Lili638,000Huang LiliHuang Lili (7)GNS Holdings LimitedHillhouse Investment Management V, Ltd.2025630173,348,965Hillhouse Investment Management V, Ltd.GNS Holdings LimitedGNS IIHoldings LimitedHillhouse Fund V, L.P.Hillhouse Investment Management, Ltd.HillhouseFund V, L.P. 2025630XV23336 20157152015127202462120193222019202462120218232021202252620246212019 624,54020256112019A20256112019624,5402019 6,777,1202025611202169,828B2025611202120256116,777,120306,6166,470,504 20246212024212,768,651202410%2019202121,276,86520241% 2025630(i)120.1%(ii)1% 202511211,642,17421,