世界卫生组织登革热、基孔肯雅病、寨卡病毒和黄热病虫媒病毒病临床管理指南

WHO guidelines for clinicalmanagement of arboviral diseases:dengue, chikungunya, Zika and yellow fever WHO guidelines for clinical management of arboviral diseases: dengue, chikungunya, Zika and yellow feverISBN978-92-4-011111-0(electronic version)ISBN 978-92-4-011112-7 (print version)© World Health Organization2025Some rightsreserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0IGO licence (CCBY-NC-SA3.0IGO;https://creativecommons.org/licenses/by-nc-sa/3.0/igo).Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes,providedthe work is appropriately cited, as indicated below. In any use of this work, there should be nosuggestion that WHO endorses anyspecific organization, products or services. The use of the WHO logo is notpermitted. If you adapt the work, then you must license your work under the same or equivalent CreativeCommons licence. If you create a translation of this work, you should add the following disclaimer along with thesuggested citation:“This translation was not created by the World Health Organization (WHO). WHO is notresponsible for the content or accuracy of this translation. The original English edition shall be the binding andauthentic edition”.Any mediation relating to disputes arising under the licence shall be conducted in accordance with themediation rules of the World Intellectual Property Organization (http://www.wipo.int/amc/en/mediation/rules/).Suggested citation.WHO guidelines for clinical management of arboviral diseases: dengue, chikungunya, Zikaand yellow fever.Geneva: World Health Organization;2025. Licence:CCBY-NC-SA3.0IGO.Cataloguing-in-Publication (CIP) data.CIP data are available athttps://iris.who.int/.Sales, rights and licensing.To purchase WHO publications, seehttps://www.who.int/publications/book-orders.To submit requests for commercial use and queries on rights and licensing, seehttps://www.who.int/copyright.Third-party materials.If you wish to reuse material from this work that is attributed to a third party, such astables, figures or images, it is your responsibility to determine whether permission is needed for that reuse andto obtain permission from the copyright holder. The risk of claims resulting from infringement of any third-party-owned component in the work rests solely with the user.General disclaimers.The designations employed and the presentation of the material in this publication do notimply the expression of any opinion whatsoever on the part of WHO concerning the legal status of any country,territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted anddashed lines on maps represent approximate border lines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsedor recommended by WHO inpreference to others of a similar nature that are not mentioned. Errors andomissions excepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by WHO to verify the information contained in this publication.However, the published material is being distributed without warranty of any kind, either expressed or implied.The responsibility for the interpretation and use of the material lies with the reader. In no event shall WHO beliable for damages arising from its use.Design:Jamie Rylance ContentsAcknowledgments...................................................................................................vi1Executive summary............................................................................................12Introduction.......................................................................................................32.1Background......................................................................................................................32.2Dengue............................................................................................................................62.3Chikungunya....................................................................................................................82.4Zika..................................................................................................................................92.5Yellow fever....................................................................................................................102.6Laboratory confirmation.................................................................................................122.7Identifying severe arboviral disease.................................................................................132.8Purpose.........................................................................................................................142.9Scope and target audience..........................................................