Prime Medicine Inc 2025年季度报告

QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 ORTRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934For the transition period from ___________________ to ___________________Commission file number001-41536 (State or other jurisdiction of incorporation or organization) SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS This Quarterly Report on Form 10-Q contains express or implied statements which are made pursuant to the safe harbor provisions ofSection 27A of the Securities Act of 1933, as amended, (the “Securities Act”) and Section 21E of the Securities Exchange Act of 1934,as amended (the “Exchange Act”). All statements, other than statements of historical facts, contained in this Quarterly Report on Form 10-Q, including statements regarding our strategy, future operations, future financial position, future revenue, projected costs,prospects, plans, and objectives of management, are forward-looking statements, which are based on management’s belief and uncertainties. The words “anticipate,” “believe,” “envision,” “estimate,” “expect,” “goal,” “intend,” “may,” “plan,” “predict,”“project,” “strategy,” “target,” “potential,” “will,” “would,” “could,” “should,” “continue,” “contemplate,” “vision” and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying The forward-looking statements in this Quarterly Report on Form 10-Q include statements about: •the initiation, timing, progress and results of our research and development programs, product candidates, preclinical studies and future clinical trials;•our ability to demonstrate, and the timing of, preclinical proof-of-conceptin vivofor multiple programs; develop our pipeline; •the ability of our Prime Editing technology to address unmet medical needs in patients; •the implementation of our strategic plans for our business, programs and technology;•the scope and duration of protection we are able to establish and maintain for intellectual property rights covering our PrimeEditing technology;•developments related to our competitors and our industry; •our ability to maintain collaborations or strategic relationships and the ability to identify and enter into future licenseagreements and collaborations;•developments related to our Prime Editing technology; •our estimates of our expenses, capital requirements, needs for additional financing;•the effect of unfavorable macroeconomic conditions or market volatility resulting from national or global economicconditionsor geopolitical developments,including rising inflation and capital market disruptions,changes in U.S.governmental agencies, new or increased international tariffs and retaliatory tariffs, trade protection measures, economicsanctions and economic slowdowns or recessions; •our expectations regarding the anticipated timeline of our cash runway, future financial performance and our ability tocontinue as a going concern; and Report on Form 10-Q and in subsequent SEC filings, particularly in the “Risk Factors” section, that we believe could cause actualresults or events to differ materially from the forward-looking statements that we make. Unless otherwise disclosed, our forward- looking statements do not reflect the potential impact of any future acquisitions, mergers, dispositions, collaborations, joint ventures or This Quarterly Report on Form 10-Q also contains estimates, projections and other information concerning our industry, our businessand the markets for our product candidates. Such information is inherently subject to uncertainties and actual events or circumstances may differ materially from events and circumstances that are assumed in this information. Unless otherwise expressly stated, weobtained statistical and other industry and market data from our own internal estimates and research, as well as from reports, industrypublications and research, surveys, studies and similar data prepared by market research firms and other third parties, industry, medicaland general publications, government data and similar sources. While we are not aware of any misstatements regarding any third-partyinformation presented in this Quarterly Report on Form 10-Q, their estimates, in particular as they relate to projections, involve numerous assumptions, are subject to risks and uncertainties and are subject to change based on various factors, including those discussed under the section titled “Risk Factors” set forth in Part II, Item 1A of this Quarterly Report on Form 10-Q, if any, our Annual Report on Form 10-K that was filed with the SEC on February28, 2025, and in other SEC filings. CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited)Three Months EndedMarch 31, Adjustments to reconcile net loss to net cash used in operating activities Stock-based compensation expense5,681Non cash lease expense2,413Depreciation expens